At Princeton’s new Lewis-Sigler Institute, Botstein is spearheading an innovative effort at interdisciplinary undergraduate education. Students will take advantage of state of the art laboratories and computers capable of crunching vast amounts of data generated by actual research. Professors will “provide essential fundamental concepts as required, using the just-in-time-principle” - no more of the “learn this now, it will be good for you later” approach, which Botstein likens to hazing. Botstein says there is “lots of overhead in teaching historical and traditional origins” so his students will learn instead “with ideas and technologies of today.” He wants to create a new basic language that will enable his biology students to make sense of the fundamental issues of other disciplines.

MIT researchers have found that the pigments responsible for the blue-green stain of the mucus that clogs the lungs of cystic fibrosis (CF) patients are primarily signaling molecules that allow large clusters of the opportunistic infection agent, Pseudomonas aeruginosa, to organize themselves into structured communities.
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P. aeruginosa appears as a classic opportunistic infection, easily shrugged off by healthy people but a grave threat to those with CF, which chokes the lungs of its victims with sticky mucus.

“We have a long way to go before being able to test this idea, but the hope is that if survival in the lung is influenced by phenazine — or some other electron-shuttling molecule or molecules — tampering with phenazine trafficking might be a potential way to make antibiotics more effective,” said Newman, whose lab investigates how ancestral bacteria on the early Earth evolved the ability to metabolize minerals.

“Our approach — ‘partial capture’ — can get CO2 emissions from coal-burning plants down to emissions levels of natural gas power plants,” said Ashleigh Hildebrand, a graduate student in chemical engineering and the Technology and Policy Program. “Policies such as California’s Emissions Performance Standards could be met by coal plants using partial capture rather than having to rely solely on natural gas, which is increasingly imported and subject to high and volatile prices.”
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The researchers conclude that as a near-term measure, partial capture looks promising. New coal plants with lower CO2 emissions would generate much-needed electricity while also demonstrating carbon capture and providing a setting for testing CO2 storage — steps that will accelerate the large-scale deployment of full capture in the future.

Jodie Wu, an MIT senior in mechanical engineering, spent the summer traveling from village to village in Tanzania to introduce a new system for processing the corn: A simple attachment for a bicycle that makes it possible to remove the kernels quickly and efficiently using pedal power. The device makes processing up to 30 times faster and allows one person to complete the job alone in one day.

The basic concept for the maize-sheller was first developed in Guatemala by an NGO called MayaPedal, and then refined by Wu last semester as a class project in D-Lab: Design, a class taught by Department of Mechanical Engineering Senior Lecturer Amy Smith. Now, thanks to Wu’s efforts, the technology is beginning to make its way around the world.
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Thus, the owner of a bicycle, with a small extra investment, can travel from village to village to carry out a variety of useful tasks. A simple bike thereby becomes an ongoing source of income.

Wu refined the corn-sheller system, which was originally designed as a permanent installation that required a bicycle dedicated solely to that purpose, to make it an add-on, like Kiwia’s tools, that could be easily bolted onto an ordinary bike and removed easily.

“Today the Broad Institute is the world’s leading genomics and biomedical institute, and we’re now making a $600 million bet that the Broad will be the place where the greatest scientific discoveries take place,” Eli Broad said at today’s ceremony.
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In its short history, the Broad Institute’s accomplishments include cataloging and identifying genetic risk factors for diseases such as type 2 diabetes and autism; discovering new therapeutic targets for cancer, malaria, and other diseases; and applying genomic tools to better understand and treat human pathogens like tuberculosis.
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The Broads’ gift is the largest to support biomedical research at a university anywhere in the world. The Broads initially invested $100 million in 2003 as a way to test the institute’s new approach to biomedical research. By 2005, the Broad Institute had already made significant accomplishments and progress, and the Broads invested a second $100 million. Their endowment of $400 million today will allow the Broad Institute to transition to a permanent, non-profit 501(c)(3) organization with both Harvard and MIT still at the heart of it, continuing to help govern the institute.

Dolphins do sleep, but not quite in the same way that people do. They sleep with one half of the brain at a time and with one eye closed. Dolphins rest this way on and off throughout the day, switching which side of the brain they shut down. During these periods, everything inside the dolphin slows down, and the mammal moves very little.

Michael Metzger’s software tool, created as part of the research for his PhD dissertation, could allow emergency managers to better decide early on whether and when to order evacuations — and, crucially, to do so more efficiently by clearing out people in stages. The tool could also help planners optimize the location of relief supplies before a hurricane hits.
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“All in all, this is a complex balancing act,” Metzger says.

The concept of evacuating an area in stages — focusing on different categories of people rather than different geographical locations — is one of the major innovations to come out of Metzger’s work, since congestion on evacuation routes has been a significant problem in some cases, such as hurricanes Katrina and Rita. Metzger suggests that, for example, the elderly might be evacuated first, followed by tourists, families with children, and then the remaining population. The determination of the specific categories and their sequence could be determined based on the demographics of the particular area.

By spacing out the evacuation of different groups over a period of about two days, he says, the process would be more efficient, while many traditional systems of evacuating a given location all at once can and have caused serious congestion problems.
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Other factors that could help to make evacuations more effective, he says, include better planning in the preparation of places for evacuees to go to, making sure buses and other transportation are ready to transport people, and preparing supplies in advance at those locations.

Hundreds of insect species spend much of their time underwater, where food may be more plentiful. MIT mathematicians have now figured out exactly how those insects breathe underwater.

By virtue of their rough, water-repellent coat, when submerged these insects trap a thin layer of air on their bodies. These bubbles not only serve as a finite oxygen store, but also allow the insects to absorb oxygen from the surrounding water.

“Some insects have adapted to life underwater by using this bubble as an external lung,” said John Bush, associate professor of applied mathematics, a co-author of the recent study.

Thanks to those air bubbles, insects can stay below the surface indefinitely and dive as deep as about 30 meters, according to the study co-authored by Bush and Morris Flynn, former applied mathematics instructor. Some species, such as Neoplea striola, which are native to New England, hibernate underwater all winter long.

Hudson’s team is focusing on the state of matter that exists at temperatures just above the temperature at which materials start to superconduct. This state, known as the pseudogap, is poorly understood, but physicists have long believed that characterizing the pseudogap is important to understanding superconductivity.

In their latest work, published online on July 6 in Nature Physics, they suggest that the pseudogap is not a precursor to superconductivity, as has been theorized, but a competing state. If that is true, it could completely change the way physicists look at superconductivity, said Hudson.

“Now, if you want to explain high-temperature superconductivity and you believe the pseudogap is a precursor, you need to explain both. If it turns out that it is a competing state, you can instead focus more on superconductivity,” he said.

The charcoal project is the responsibility of Mary Hong, a 19-year-old branching out beyond her aerospace major this semester. She and the other students, coincidentally all women, are enrolled in Smith’s D-Lab, a course that is becoming quietly famous beyond the MIT campus in Cambridge, Mass. The D is for development, design and dissemination; last fall, more than 100 students applied for about 30 slots. To prepare for their field work, D-Lab students live for a week in Cambridge on $2 per day. (Smith joins in.) Right now, eight more D-Lab teams are plying jungle rivers, hiking goat trails and hailing chicken buses in seven additional countries—Brazil, Honduras, Ghana, Tanzania, Zambia, India and China. In Smith’s view, even harsh aspects of Third World travel have their benefits. “If you get a good bout of diarrhea from a waterborne disease,” she says, “you really understand what it means to have access to clean drinking water.”
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Despite their simplicity, Smith’s creations made her a minor celebrity at MIT, and in 2000 she became the first woman to win the $30,000 Lemelson-MIT Student Prize. The same year, she began teaching full time at the university. It was nearly 30 years since German economist E.F. Schumacher had published Small is Beautiful: Economics as if People Mattered, the book credited with launching the appropriate technology movement. Schumacher argued that many of the infrastructure projects funded by the World Bank and other organizations hadn’t improved lives on the village level. “He rightly and aptly pointed out that big solutions don’t fit for villages. You have to make it small,”

MIT researchers have developed a novel technique to measure the strength of the bonds between two protein molecules important in cell machinery: Gently tugging them apart with light beams. “It’s really giving us a molecular-level picture of what’s going on,” said Matthew Lang, an assistant professor of biological and mechanical engineering
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The researchers studied the interactions between the proteins by pinning one actin filament to a surface and controlling the motion of the second one with a beam of light. As the researchers tug on a bead attached to the second filament, the bond mediated by the actin-binding protein eventually breaks.

With this technique, the researchers can get a precise measurement of the force holding the proteins together, which is on the order of piconewtons (10^-12 newtons).

MIT researchers have designed a new type of probe that can image thousands of interactions between proteins inside a living cell, giving them a tool to untangle the web of signaling pathways that control most of a cell’s activities.

“We can use this to identify new protein partners or to characterize existing interactions. We can identify what signaling pathway the proteins are involved in and during which phase of the cell cycle the interaction occurs,” said Alice Ting, the Pfizer-Laubach Career Development Assistant Professor of Chemistry and senior author of a paper describing the probe published online June 27 by the Journal of the American Chemical Society.

The new technique allows researchers to tag proteins with probes that link together like puzzle pieces if the proteins interact inside a cell. The probes are derived from an enzyme and its peptide substrate. If the probe-linked proteins interact, the enzyme and substrate also interact, which can be easily detected.

To create the probes, the researchers used the enzyme biotin ligase and its target, a 12-amino-acid peptide.

His exposure to polymer science led him to pursue a Ph.D. in chemistry from Virginia Polytechnic Institute and State University in Blacksburg, Va. At the age of 25, DeSimone joined the University of North Carolina at Chapel Hill (UNC) as an assistant professor in chemistry and launched the university’s polymer program with his mentor Dr. Edward Samulski. He resides there today as the Chancellor’s Eminent Professor of Chemistry at UNC, in addition to serving as the William R. Kenan, Jr. Distinguished Professor of Chemical Engineering at North Carolina State University.

Among DeSimone’s notable inventions is an environmentally friendly manufacturing process that relies on supercritical carbon dioxide instead of water and bio-persistent surfactants (detergents) for the creation of fluoropolymers or high-performance plastics, such as Teflon®. More recently, he worked on a team to design a polymer-based, fully bioabsorbable, drug-eluting stent, which helps keep a blocked blood vessel open after a balloon-angioplasty and is absorbed by the body within 18 months.

DeSimone’s newest invention is PRINT® (Particle Replication in Non-wetting Templates) technology, used to manufacture nanocarriers in medicine. At present, DeSimone’s Lab is vested in a variety of projects that also extend beyond medicine, including potential applications for more efficient solar cells and morphable robots. In 2004, DeSimone co-founded Liquidia Technologies with a team of researchers from UNC to make the technology available in the market. Liquidia is using the PRINT technology to develop precisely engineered nanocarriers for highly targeted delivery of biological and small molecule therapeutics to treat cancer and other diseases. DeSimone’s proposed applications for cancer treatment with the PRINT platform was instrumental in UNC landing a grant of $24 million from the National Cancer Institute to establish the Carolina Center for Cancer Nanotechnology Excellence.

“You can do all the innovating you want in the laboratory, but if you can’t get it out of the university walls you do no one any good,” said DeSimone. He instills an entrepreneurial spirit in his students that focuses on the importance of commercializing technology and scientific inventions. One of DeSimone’s greatest accomplishments is his mentorship of more than 45 postdoctoral research associates, 52 Ph.D. candidates, six M.S. theses and 21 undergraduate researchers. Furthermore, he speaks to groups of high school students about the inventive process and encourages them to learn and explore areas that are less familiar to them to broaden their exposure to other disciplines.

A prolific inventor, DeSimone holds more than 115 issued patents with more than 70 new patent applications pending, and he has published more than 240 peer-reviewed scientific articles.