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Posts about cool products including high tech gadgets, appropriate technology solutions and possible products in the future. Recommended posts: Lego Learning (mindstorms) - Lifestraw - Video Goggles - Wakamaru Robot - Re-engineered Wheelchair

Lactic Acid Bacteria in Bees Counteracted Antibiotic-Resistant MRSA in Lab Experiments

13 lactic acid bacteria found in the honey stomach of bees have shown promising results as an antibiotic treatment in a series of studies at Lund University in Sweden (Open access paper: Lactic acid bacterial symbionts in honeybees – an unknown key to honey’s antimicrobial and therapeutic activities). The group of bacteria counteracted antibiotic-resistant MRSA in lab experiments. The bacteria, mixed into honey, has healed horses with persistent wounds. The formula has also previously been shown to protect against bee colony collapse.

photo of a bee on a flower

Photo by Justin Hunter

Raw honey has been used against infections for millennia, before honey – as we now know it – was manufactured and sold in stores. So what is the key to its’ antimicrobial properties? Researchers at Lund University in Sweden have identified a unique group of 13 lactic acid bacteria found in fresh honey, from the honey stomach of bees. The bacteria produce a myriad of active antimicrobial compounds.

These lactic acid bacteria have now been tested on severe human wound pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa and vancomycin-resistant Enterococcus (VRE), among others. When the lactic acid bacteria were applied to the pathogens in the laboratory, it counteracted all of them.

While the effect on human bacteria has only been tested in a lab environment thus far, the lactic acid bacteria has been applied directly to horses with persistent wounds. The LAB was mixed with honey and applied to ten horses; where the owners had tried several other methods to no avail. All of the horses’ wounds were healed by the mixture.

The researchers believe the secret to the strong results lie in the broad spectrum of active substances involved.

“Antibiotics are mostly one active substance, effective against only a narrow spectrum of bacteria. When used alive, these 13 lactic acid bacteria produce the right kind of antimicrobial compounds as needed, depending on the threat. It seems to have worked well for millions of years of protecting bees’ health and honey against other harmful microorganisms. However, since store-bought honey doesn’t contain the living lactic acid bacteria, many of its unique properties have been lost in recent times”, explains Tobias Olofsson.

This is a very cool: “When used alive, these 13 lactic acid bacteria produce the right kind of antimicrobial compounds as needed, depending on the threat.” As is the note that store bought honey doesn’t contain the living bacteria. My guess is some honey bought directly from farmers or bee-keepers, at farmer’s markets may well still have those live bacteria – but I am just guessing I may be wrong.

The next step is further studies to investigate wider clinical use against topical human infections as well as on animals.

The findings have implications for developing countries, where fresh honey is easily available, but also for Western countries where antibiotic resistance is seriously increasing.

Related: People are Superorganisms With Microbiomes of Thousands of SpeciesThe Search for Antibiotic Solutions Continues: Killing Sleeper Bacteria CellsOur Dangerous Antibiotic Practices Carry Great RisksPotential Antibiotic Alternative to Treat Infection Without Resistance
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Self Driving Cars Have Huge Potential for Benefit to Society

Self-driving cars was something that seemed very far-fetched when I first read Google was seriously investing in pursuing that idea as a commercially viable product (Google’s Self Driving Car – 2010 post). I quickly became convinced they were right. I still think it is questionable if they will succeed (the political issues may well be even more difficult than technical ones). But the chances of success seem reasonable and the investment in research could provide a huge payoff.

Google’s self driving cars have driven 700,000 miles without an accident already; which is amazing. Warren Buffett stated that “self-driving cars are a real threat to the car insurance business” (His company owns the GIECO car insurance company) at the 2014 Berkshire Hathaway shareholder meeting in Omaha.

There are some people, stressing that this is not ready for mass market use. They are right. But, I think it is funny to see people thinking that a very early stage huge innovation in transportation not being ready today is a reasonable criticism. I am amazed that this huge innovation may actually be available before 2020. That would be incredible.

Certainly even then it will have limitations. And certainly there will be accidents. The current transportation system with humans driving cars has thosands of accidents a day and tens of thousands of deaths a year in the USA alone every year. Every year 1.2 million people die worldwide in traffic-related incidents, and over 90% of those accidents are due to human error.

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DIY Air Filters for Your House

In January 2013 PhD student Thomas Talhelm, was living in Bejing, China with very bad air pollution and wondered why air purifiers cost so much. He bought a HEPA filter on Taobao, strapped it to a simple fan, bought a particle counter, ran some tests, and published the results.

As the effort gained publicity and people said they had trouble finding the right type of fan and a trustworthy HEPA, Thomas and his friends Gus and Anna decided to launch Smart Air in September 2013 to ship fans and the best HEPAs they could find to people all over China.

Smart Air believes that if more people saw their open­ source data and testing, more people would know that clean air doesn’t have to cost thousands of RMB (hundred of USD). The simplest solution (a fan, filter and strap to hold the filter to a fan) costs 200 RMB (under US $35).

I love simple solutions. And I love entrepreneurship combined with engineering to provide customers value.

Related: Air Pollution Resulted in 223,000 Cancer Deaths in 2010Extremely Bad Haze in Johor Bahru and SingaporeUsing Drones to Deliver Medical Supplies in Roadless AreasPay as You Go Solar in India

It is also great that they provide useful data including: HEPAs lasted 90 days without any drop in effectiveness, then effectiveness dropped by 4% between days 100-130. It’s up to you to decide whether that 4% is enough to warrant changing your filter after 3 months of nightly use.

iPhone Addition as Alternative to Expensive Ophthalmology Equipment

Researchers at the Stanford University School of Medicine have developed two inexpensive adapters that enable a smartphone to capture high-quality images of the front and back of the eye. The adapters make it easy for anyone with minimal training to take a picture of the eye and share it securely with other health practitioners or store it in the patient’s electronic record.

The researchers see this technology as an opportunity to increase access to eye-care services as well as to improve the ability to advise on patient care remotely.

The standard equipment used to photograph the eye is expensive — costing up to tens of thousands of dollars — and requires extensive training to use properly. Primary care physicians and emergency department staff often lack this equipment, and although it is readily available in ophthalmologists’ offices, it is sparse in rural areas throughout the world.

“Adapting smartphones for the eye has the potential to enhance the delivery of eye care — in particular, to provide it in places where it’s less accessible,” said Myung. “Whether it’s in the emergency department, where patients often have to wait a long time for a specialist, or during a primary-care physician visit, we hope that we can improve the quality of care for our patients, especially in the developing world where ophthalmologists are few and far between.”

“A picture is truly worth a thousand words,” he added. “Imagine a car accident victim arriving in the emergency department with an eye injury resulting in a hyphema — blood inside the front of her eye. Normally the physician would have to describe this finding in her electronic record with words alone. Smartphones today not only have the camera resolution to supplement those words with a high-resolution photo, but also the data-transfer capability to upload that photo securely to the medical record in a matter of seconds.

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Water Wheel

As I have posted before I really love appropriate technology solutions that make a difference in people’s lives. And those that help those that have the largest challenges (the very poor where even water and electricity are challenges).

hello wello from wello on Vimeo.

Wello is a venture to improve people’s lives, they found women spend over 25% of their time each day collecting water. With the WaterWheel, they can now transport 50 liters at once – between 3 and 5 times the amount of water possible as compared to traditional methods: this means more water in less time.

Research shows that when women have extra time, they choose to spend it on activities that boost family income, education, health, and wellbeing.

Related: Clay Water Filters for GhanaEngineering a Better World: Bike Corn-ShellerPedal Powered Washing Machine

Using Drones to Deliver Medical Supplies in Roadless Areas

This is an awesome use of technology to tackle important problems. Engineers are great.

Humanitarian drones to deliver medical supplies to roadless areas

That idea soon became a start-up called Matternet – a network for transporting matter – which aims to help the one billion people who do not have year-round access to roads.

[Andreas] Raptopoulos said the new system would be used to leapfrog the building of infrastructure, in the same way mobile networks have overtaken fixed lines in poorly connected countries.

In sub-Saharan Africa, 85% of roads are inaccessible during the wet season, cutting off huge swaths of the population and hindering the transport of medical supplies, he said.

There are three parts to the system delivering medical goods: the UAVs themselves, landing stations where packages can be dropped off and transferred, and the software that ensures vehicles get securely from point to point. Because of their short battery life, networks of drones are needed to work together, shuttling between ground stations

Approximate costings from Matternet put the price of unmanned aerial vehicles at £6,000 each and ground stations at £3,000 each. A network of five ground stations and 10 UAVs, as well as setup and training, would cost a charity in the region of £90,000, according to Raptopoulos. An eight-propeller drone can carry 2kg and travel 10km in good weather. Batteries need to be replaced every 600 cycles.

They are hiring: software engineer and avionic engineering right now. They are Palo Alto, California.

Related: Appropriate Technology Health Care Solution Could Save 72,000 Lives a YearCellphone MicroscopePay as You Go Solar in IndiaWater and Electricity for All

Pedal Powered Washing Machine

It is very easy to forget billions of people alive today do not have access to electricity, clean water and things like washing machines at home. As I have said before I love appropriate technology. Even more than that I love to see successful deployments of appropriate technology that make people’s lives better.

It is also great to see kids with the perseverance to make these products to meet needs they see around them. We need to do what we can to encourage these types of kids. They are the future engineers and entrepreneurs that will make lives better for the rest of society.

Remya Jose, a 14 year school girl from Kerala, India created this wonderful machine. Another version of it, has the normal bike pedals (closer together, instead of spread out, on opposite sides of the machine, like in the video).

As far as I can tell the original video was from 2008 (and Remya created the machine in 2005). I haven’t been able to find the current status of the product, this is the best I could find (from 2008). Turning these innovations into products that succeed commercially is very hard.

If I had control of a national development program (or if I just become super rich and have millions to devote to making the world better, I think an effort like this would be something I would try) I would put working with these kids to make the products work very high on my list of priorities. The learning process and creation of engineers and entrepreneurs would be extremely valuable on top of any success the products had.

Related: Appropriate Technology: Washing Clothes by Machine Instead by HandWashing Machine Uses 90% Less WaterEngineering a Better World: Bike Corn-Shelleranother bicycle washing machineAutomatic Dog Washing Machine

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Battery Breakthrough Using Organic Storage

Battery offers renewable energy breakthrough

a metal-free flow battery that relies on the electrochemistry of naturally abundant, inexpensive, small organic (carbon-based) molecules called quinones, which are similar to molecules that store energy in plants and animals.

The mismatch between the availability of intermittent wind or sunshine and the variable demand is the biggest obstacle to using renewable sources for a large fraction of our electricity. A cost-effective means of storing large amounts of electrical energy could solve this problem.

Flow batteries store energy in chemical fluids contained in external tanks, as with fuel cells, instead of within the battery container itself. The two main components — the electrochemical conversion hardware through which the fluids are flowed (which sets the peak power capacity) and the chemical storage tanks (which set the energy capacity) — may be independently sized. Thus the amount of energy that can be stored is limited only by the size of the tanks. The design permits larger amounts of energy to be stored at lower cost than with traditional batteries.

This looks like a very interesting field of research. Storing power remains one of the challenges for renewable energy sources such as solar and wind. This is especially true if the use is disconnected from the grid, but is even true for grid-connected uses. Especially as increasing the amount of wind and solar energy make it increasingly likely that surplus energy is created at certain times.

The research seems to allow for sensible size home storage setups. At the commercial level the volume needed is very large. Another concern to be addressed is how many cycles the “battery” is good for before it degrades; current experimentation show no degradation after 100 cycles but consumer/commercial usage will need thousands of cycles.

Related: Battery Breakthrough (solid sodium metal mated to a sulphur compound by an extraordinary, paper-thin ceramic membrane)Energy Storage Using Carbon Nanotubes (2006)Chart of Wind Power Generation Capacity Globally 2005-2012Recharge Batteries in Seconds

Hacking the Standard Bike Wheel

The Copenhagen Wheel stores energy (from braking…) and provides it when you need it (going up hill…). It is good to see innovation that helps transportation and can encourage people to be more active. Order now for $799.

Related: Engineering a Better World: Bike Corn-ShellerSeparated Bike Lanes Reduced Injuries by 45% and Increased Retail Sales 49% (for nearby stores)Bike Folds To Footprint of 1 WheelSports Engineering at MIT

Search for Antibiotic Solutions Continues: Killing Sleeper Bacteria Cells

Killing Sleeper Cells and Superbugs with Assassin Janitors

Discovered in 2005 by scientists from Bayer Healthcare in Germany, ADEP4 killed a variety of different bacteria and cured lethal infections in mice and rats.

Here’s how it works. Proteins need to fold into very precise shapes to do their jobs, and misfolded proteins are wastes of space. Bacteria dispose of these useless molecules with ClpP—a janitorial protein that digests other proteins. It works with a partner, which recognises misfolded proteins, unfolds them, and threads them through a hole in the middle of ClpP so they can be broken down. But ADEP4 opens ClpP up so it no longer needs its partner. The janitor now becomes an assassin, running amok and chopping up any protein it comes across, misfolded or not.

The Bayer scientists showed that ADEP4 can force fast-growing cells to self-destruct, but Lewis suspected that it would do the same to persisters. Afterall, ClpP’s partner requires energy to do its job, but ClpP itself doesn’t. Once ADEP4 opens it up, it should go about its fatal business even in a dormant cell.

Lewis’ team found that ADEP4 did effectively kills persister populations of Staphylococcus aureus, but the bacteria bounce back. ClpP isn’t essential, so the bacteria just inactivated it to evolve their way around ADEP4. This, says Lewis, is why Bayer stopped working on the drug.

His solution was to pair ADEP4 with another antibiotic called rifampycin. ADEP4 would kill off the majority of the persisters, and if any of the rest started growing again, rifampycin would finish them off. He predicted that the double-whammy would leave very few survivors, maybe just a thousand cells or so.

“That’s not what we saw,” he says. “What we saw was complete sterilisation.”

This is a very nice effort. As our efforts fail to find “magic bullet” antibiotics fail and antibiotic resistance increases combo drug solutions offer some hope. While this is good news, the overall state of our ability to treat bacterial infections continues to decline as our misuse of antibiotics has greatly increased the speed at which antibiotic resistance has developed in bacteria.

This solution only works on gram positive antibiotics. ADEP4 is too big to pass through the extra outer layers of the gram-negative bacteria like ecoli and salmonella.

Related: Entirely New Antibiotic Developed, Platensimycin (2006) (2013 update: Platensimycin is a very effective antibiotic in vivo when continuously administered to cells, however this efficacy is reduced when administered by more conventional means. Efforts continue to find a way to create delivery options that are successful in treating people.) – New Family of Antibacterial Agents Discovered (2009)Potential Antibiotic Alternative to Treat Infection (2012)

Appropriate Technology Brings a $1.30/month Cell Phone Plan to Remote Village

I love this kind of stuff: smart use of engineering provides cell phone service to remote Mexican village, with 9,000 residents, for $1.30/month (1/13 of the price charge by traditional cell phone service in Mexico City).

The town that Carlos Slim forgot

It’s so remote that there was no cell service. In stepped Rhizomatica, a nonprofit with the goal of increasing “access to mobile telecommunications to the over two billion people without affordable coverage and the 700 million with none at all.”

The U.S. and European experts working with Mexican engineers got the network set up by March of this year. At first, they ruled that phone calls were not to be longer than five minutes each to keep the small network from getting saturated.

By May, local numbers in Mexico City, Los Angeles and Seattle were set up, meaning that Oaxacans in Villa Talea could call relatives in the capital or in California as if it were practically a local call, a few cents a minute.

Given the success they are buying equipment that can handle the volume and will donate the existing equipment to setup a new village (a smaller one, I imagine). This was the first village they setup.

Long-distance is go

After almost two months of fine-tuning, long-distance service is finally ready to launch. This means folks in the town will be able to call out of the coverage area (only around 5-10km) to any phone, anywhere. Likewise we purchased a few DID numbers which allow people to call a Mexico City, Los Angeles or Seattle number and connect right to the village.

This is one of so many great efforts to use appropriate technology to improve people’s lives. It is easy for me to get frustrated at the cash for votes mentality of the USA politicians which creates policies against improvement for society and for protection of obsolete business models (until the bought-and-paid-for politicians make the business models sustainable by legislating against better options). It is great to see these kind of examples for the good work being done outside of the political sphere.

Related: Pay as You Go Solar in IndiaProviding Computer to Remote Students in NepalReducing Poverty Using EntrepreneurshipMonopolies and Oligopolies do not a Free Market Make

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