Probing more deeply than ever before into the stuff of the universe requires some big hardware. It also requires the political will to lavish money on a project that has no predictable practical return, other than prestige and leadership in the branch of science that delivered just about every major technology of the past hundred years.

Those advances came, in large measure, from the United States. The coming decades may be different.
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A third of the scientists working at the LHC hail from outside the 20 states that control CERN. America has contributed 1,000 or so researchers, the largest single contingent from any non-CERN nation.
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The U.S. contribution amounts to $500 million—barely 5 percent of the bill. The big bucks have come from the Europeans. Germany is picking up 20 percent of the tab, the British are contributing 17 percent, and the French are giving 14 percent.
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The most worrying prospect is that scientists from other countries, who used to flock to the United States to be where the action is, are now heading to Europe instead.

Until recently that would also have been the opinion of most scientists. Genes, it was thought, were highly resilient. Even if people did wreck their own DNA through bad diet, smoking and getting fat, that damage was unlikely to be passed to future generations.

Now, however, those assumptions are being re-examined. At the heart of this revolution is a simple but controversial idea: that DNA can be modified or imprinted with the experiences of your parents and grandparents.

According to this new science, known as epigenetics, your ancestors’ diet, smoking habits, exposure to pollutants and levels of obesity could be affecting you today. In turn, your lifestyle could affect your children and grandchildren.
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If we drink heavily, take drugs, get fat or wait too long to reproduce, then epigenetics might start tying up some of the wrong genes and loosening the bonds on others. Sometimes those changes will affect sperm and egg cells.

So far, the signs are good. The bill commits $500 million for research facilities, infrastructure improvements, and other capital projects; $250 million for tax credits; and $250 million for research grants. The plan is flexible enough to support research at private institutions while making major investments at public universities. Patrick and legislators fended off the most flagrant attempts to divert money into political pet projects with little direct relevance to the biotech industry, such as $49.5 million for a science building at a state college with no graduate science programs.

“The mathematics behind cloaking has been known for several years,” said Professor John Pendry of Imperial College London, UK, an expert in cloaking. “What hasn’t been available for sound is the sort of materials you need to build a cloak out of.”
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The Spanish team who conducted the new work believe the key to a practical device are so-called “sonic crystals”. These artificial composites - also known as “meta-materials” - can be engineered to produce specific acoustical effects.
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The research builds on work by scientists from Duke University in North Carolina, US, and the Hong Kong University of Science and Technology. Earlier this year, independent teams from the two institutions demonstrated the mathematics necessary to create an acoustic cloak. Other scientists have shown that objects can be cloaked from electromagnetic radiation, such as microwaves.

discovered surprising magnetic properties in the new superconductors that suggest they may have very powerful applications — from improved MRI machines and research magnets, to a new generation of superconducting electric motors, generators and power transmission lines. The research also adds to the long list of mysteries surrounding superconductivity, providing evidence that the new materials, which scientists are calling “doped rare earth iron oxyarsenides,” develop superconductivity in quite a new way
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Early this year, Japanese scientists who had been developing iron-based superconducting compounds for several years, finally tweaked the recipe just right with a pinch of arsenic. The result: a superconductor, also featuring oxygen and the rare earth element lanthanum, performing at a promising -413 degrees F (26 K). The presence of iron in the material was another scientific stunner: Because it’s ferromagnetic, iron stays magnetized after exposure to a magnetic field, and any current generates such a field. As a rule, magnetism’s effect on superconductivity is not to enhance it, but to kill it.

The new superconductors seem like they will be able to make improved MRI machines and research magnets, a new generation of superconducting electric motors, generators and power transmission lines. Tesla is a unit of magnetic field strength; the Earth’s magnetic field is one twenty thousandth of a tesla.

Four decades after scientists showed that migratory birds use Earth’s magnetic field to orient themselves during their seasonal journeys, researchers have at last found a molecular mechanism that may explain how they do it.

If the hypothesis is true, the planet’s magnetic field lines — which arch around Earth from north to south — may be plainly visible to birds, like the dashed line in the middle of a road.

The work, described online yesterday in the journal Nature, was conducted in a test tube and does not prove that birds actually use the mechanism. And researchers aligned with a competing model say they are not convinced.

But by identifying for the first time a molecule that reacts to very weak magnetic fields, the experiments prove the plausibility of a long-hypothesized method of avian navigation that has had a credibility problem because no one had ever found a molecule with the required sensitivity.

Today, wheat provides about 20 percent of the food calories for the world’s people. The world wheat harvest now stands at about 600 million metric tons.

In the last decade, global wheat production has not kept pace with rising population, or the increasing per capita demand for wheat products in newly industrializing countries. At the same time, international support for wheat research has declined significantly. And as a consequence, in 2007-08, world wheat stocks (as a percentage of demand) dropped to their lowest level since 1947-48. And prices have steadily climbed to the highest level in 25 years.

The new strains of stem rust, called Ug99 because they were discovered in Uganda in 1999, are much more dangerous than those that, 50 years ago, destroyed as much as 20 percent of the American wheat crop. Today’s lush, high-yielding wheat fields on vast irrigated tracts are ideal environments for the fungus to multiply, so the potential for crop loss is greater than ever.

If publicly financed international researchers move together aggressively and systematically, high-yielding replacement wheat varieties can be developed and made available to farmers before stem rust disease becomes a global epidemic.

The Bush administration was initially quick to grasp Ug99’s threat to American wheat production. In 2005, Mike Johanns, then secretary of agriculture, instructed the federal agriculture research service to take the lead in developing an international strategy to deal with stem rust. In 2006, the Agency for International Development mobilized emergency financing to help African and Asian countries accelerate needed wheat research.

But more recently, the administration has begun reversing direction. The State Department is recommending ending American support for the international agricultural research centers that helped start the Green Revolution, including all money for wheat research. And significant financial cuts have been proposed for important research centers, including the Department of Agriculture’s essential rust research laboratory in St. Paul.

This shocking short-sightedness goes against the interests not only of American wheat farmers and consumers but of all humanity. It is tantamount to the United States abandoning its pledge to help halve world hunger by 2015.

The pathogen responsible for Sudden Oak Death first got its grip in California’s forests outside a nursery in Santa Cruz and at Mt. Tamalpais in Marin County before spreading out to eventually kill millions of oaks and tanoaks along the Pacific Coast, according to a new study led by researchers at the University of California, Berkeley. It provides, for the first time, evidence of how the epidemic unfolded in this state.
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The study, scheduled to appear later this month in the online early edition of the journal Molecular Ecology, also shows that the pathogen is currently evolving in California, with mutant genotypes appearing as new areas are infested.
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The most likely scenario, said Garbelotto, is that the pathogen arrived in California through the nursery trade, and that it then spread from the nursery in Santa Cruz to trees bordering the facility. While the site at Mt. Tamalpais is not adjacent to a nursery, there is anecdotal evidence of frequent use of ornamental plants from nurseries in landscaping projects in the area, said Garbelotto.

Every year, more than 30 billion water bottles are added to America’s landfills, creating a mountainous environmental problem. But if research at Missouri University of Science and Technology is successful, the plastic bottles of the future could literally disappear within four months of being discarded.

The Missouri S&T research team is constructing new breeds of biodegradable and bioavailable plastics in an effort to reduce the tons of plastic waste that ends up in the nation’s landfills each year. Bioavailable plastics contain substances that can be absorbed by living systems during their normal physiological functions.

By combining and modifying a variety of bio-based, oil-based and natural polymers, the team seeks to create optimal blends that can be used to make agricultural films, bottles, biomedical and drug delivery devices, and more.
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As polylactic acid degrades, the material reacts with water to decompose into small molecules, which are then mineralized into water and carbon dioxide.

“In general, the main end products of polymer degradation are water and carbon dioxide,” Shahlari explains. “Polylatic acid has the potential of replacing the regular water bottles, and we anticipate that our research could be incorporated into that field too.

An engineered material that can be injected into damaged spinal cords could help prevent scars and encourage damaged nerve fibers to grow. The liquid material, developed by Northwestern University materials science professor Samuel Stupp, contains molecules that self-assemble into nanofibers, which act as a scaffold on which nerve fibers grow.

Stupp and his colleagues described in a recent paper in the Journal of Neuroscience that treatment with the material restores function to the hind legs of paralyzed mice.
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The new work is the first test for the material to heal spinal cord injuries in animals. And Kessler says that it worked better than the researchers expected. The researchers stimulated a spinal cord injury in mice and injected the material 24 hours later. They found that the material reduced the size of scars and stimulated the growth of the nerve fibers through the scars. It promoted the growth of both types of nerve fibers that make up the spinal cord: motor fibers that carry signals from the brain to the limbs, and sensory fibers that carry sense signals to the brain. What is more, the material encouraged the nerve stem cells to mature into cells that create myelin–an insulating layer around nerve fibers that helps them to conduct signals more effectively.

Scientists from Arizona State University report that minerals from clay promise could provide inexpensive, highly-effective antimicrobials to fight methicillin-resistant Staphylococcus aureus (MRSA) infections that are moving out of health care settings and into the community.
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Unlike conventional antibiotics routinely administered by injection or pills, the so-called “healing clays” could be applied as rub-on creams or ointments to keep MRSA infections from spreading
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In their latest study, funded by the National Institutes of Health, Williams, Haydel and their colleagues collected more than 20 different clay samples from around the world to investigate their antibacterial activities… The researchers identified at least two clays from the United States that kill or significantly reduce the growth of these bacteria

The sharp beak of the Humboldt squid is one of the hardest and stiffest organic materials known. Engineers, biologists, and marine scientists at the University of California, Santa Barbara, have joined forces to discover how the soft, gelatinous squid can operate its knife-like beak without tearing itself to pieces.
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The key to the squid beak lies in the gradations of stiffness. The tip is extremely stiff, yet the base is 100 times more compliant, allowing it to blend with surrounding tissue. However, this only works when the base of the beak is wet. After it dries out, the base becomes similarly stiff as the already desiccated beak tip.
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“You can imagine the problems you’d encounter if you attached a knife blade to a block of Jell-o and tried to use that blade for cutting. The blade would cut through the Jell-o at least as much as the targeted object. In the case of the squid beak, nature takes care of the problem by changing the beak composition progressively, rather than abruptly, so that its tip can pierce prey without harming the squid in the process. It’s a truly fascinating design!”
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“If we could reproduce the property gradients that we find in squid beak, it would open new possibilities for joining materials,” explained Zok. “For example, if you graded an adhesive to make its properties match one material on one side and the other material on the other side, you could potentially form a much more robust bond,” he said. “This could really revolutionize the way engineers think about attaching materials together.”

The window for applications will be open until mid 2008, when a thorough qualification process will assess safety, cost, features and business plans to ensure that only production-capable, consumer-friendly cars compete. Those that qualify will race their vehicles in rigorous cross-country stage races in 2009 and 2010 that combine speed, distance, urban driving and overall performance. The winners will be the vehicles that exceed 100 MPG, meet strict emissions standards and finish in the fastest time. Host cities involved in the competition route are to be announced shortly.

The mounting U.S. drug price crisis can be contained and eventually reversed by separating drug discovery from drug marketing and by establishing a non-profit company to oversee funding for new medicines, according to two MIT experts on the pharmaceutical industry.
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Following the utility model, Finkelstein and Temin propose establishing an independent, public, non-profit Drug Development Corporation (DDC), which would act as an intermediary between the two new industry segments — just as the electric grid acts as an intermediary between energy generators and distributors.

The DDC also would serve as a mechanism for prioritizing drugs for development, noted Finkelstein. “It is a two-level program in which scientists and other experts would recommend to decision-makers which kinds of drugs to fund the most. This would insulate development decisions from the political winds,” he said.