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NASA Biocapsules Deliver Medical Interventions Based Upon What They Detect in the Body

Posted on February 10, 2012  Comments (0)

Very cool innovation from NASA. The biocapsule monitors the environment (the body it is in) and responds with medical help. Basically it is acting very much like your body, which does exactly that: monitors and then responds based on what is found.

The Miraculous NASA Breakthrough That Could Save Millions of Lives

The Biocapsules aren’t one-shot deals. Each capsule could be capable of delivering many metred doses over a period of years. There is no “shelf-life” to the Biocapsules. They are extremely resilient, and there is currently no known enzyme that can break down their nanostructures. And because the nanostructures are inert, they are extremely well-tolerated by the body. The capsules’ porous natures allow medication to pass through their walls, but the nanostructures are strong enough to keep the cells in one place. Once all of the cells are expended, the Biocapsule stays in the body, stable and unnoticed, until it is eventually removed by a doctor back on Earth.
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Dr. Loftus [NASA] thinks we could realistically see wildspread usage on Earth within 10 to 15 years.
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The cells don’t get released from the capsule. The cells inside the capsule secrete therapeutic molecules (proteins, peptides), and these agents exit the capsule by diffusion across the capsule wall.

NASA plans to use the biocapsules in space, but they also have very promising uses on earth. They can monitor a diabetes patient and if insulin is needed, deliver it. No need for the person to remember, or give themselves a shot of insulin. The biocapsule act just like out bodies do, responding to needs without us consciously having to think about it. They can also be used to provide high dose chemotherapy directly to the tumor site (thus decreasing the side effects and increasing the dosage delivered to the target location. Biocapsules could also respond to severe allergic reaction and deliver epinephrine (which many people know have to carry with them to try and survive an attack).

It would be great if this were to have widespread use 15 years from now. Sadly, these innovations tend to take far longer to get into productive use than we would hope. But not always, so here is hoping this innovation from NASA gets into ourselves soon.

Related: Using Bacteria to Carry Nanoparticles Into Cells – Nanoparticles With Scorpion Venom Slow Cancer Spread – Self-Assembling Cubes Could Deliver Medicine – Nanoengineers Use Tiny Diamonds for Drug Delivery

Webcast of a T-cell Killing a Cancerous Cell

Posted on February 9, 2012  Comments (0)

Very cool. Very good job by University of Cambridge to make this kind of material available openly online. I find this kind of video amazing. Every day you body has this going on all day long. How amazing.

This is what it looks like when cancer gets smacked down by a T cell

This was shot by University of Cambridge medical researcher Alex Ritter, and is 92 times faster than real time.
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Cells of the immune system protect the body against pathogens. If cells in our bodies are infected by viruses, or become cancerous, then killer cells of the immune system identify and destroy the affected cells. Cytotoxic T cells are very precise and efficient killers. They are able to destroy infected or cancerous cells, without destroying healthy cells surrounding them.

Related: Using Bacteria to Carry Nanoparticles Into Cells – How Cells Age – Video showing malaria breaking into cell – Synthetic Biologists Design a Gene that Forces Cancer Cells to Commit Suicide

Microbiologist Develops Mouthwash That Targets Only Harmful Cavity Causing Bacteria

Posted on February 1, 2012  Comments (0)

A new mouthwash developed by a microbiologist at the UCLA School of Dentistry is highly successful in targeting the harmful Streptococcus mutans bacteria that is the principal cause tooth decay and cavities.

In a recent clinical study, 12 subjects who rinsed just one time with the experimental mouthwash experienced a nearly complete elimination of the S. mutans bacteria over the entire four-day testing period.

Dental caries, commonly known as tooth decay or cavities, is one of the most common and costly infectious diseases in the United States, affecting more than 50 percent of children and the vast majority of adults aged 18 and older. Americans spend more than $70 billion each year on dental services, with the majority of that amount going toward the treatment of dental caries.

This new mouthwash is the product of nearly a decade of research conducted by Wenyuan Shi, chair of the oral biology section at the UCLA School of Dentistry. Shi developed a new antimicrobial technology called STAMP (specifically targeted anti-microbial peptides) with support from Colgate-Palmolive and from C3-Jian Inc., a company he founded around patent rights he developed at UCLA; the patents were exclusively licensed by UCLA to C3-Jian.

The human body is home to millions of different bacteria, some of which cause diseases such as dental caries but many of which are vital for optimum health. Most common broad-spectrum antibiotics, like conventional mouthwash, indiscriminately kill both benign and harmful pathogenic organisms and only do so for a 12-hour time period.

The overuse of broad-spectrum antibiotics can seriously disrupt the body’s normal ecological balance, rendering humans more susceptible to bacterial, yeast and parasitic infections.

Shi’s Sm STAMP C16G2 investigational drug, tested in the clinical study, acts as a sort of “smart bomb,” eliminating only the harmful bacteria and remaining effective for an extended period.

“With this new antimicrobial technology, we have the prospect of actually wiping out tooth decay in our lifetime,” said Shi, who noted that this work may lay the foundation for developing additional target-specific “smart bomb” antimicrobials to combat other diseases.

Related: full press release – False Teeth For Cats – Cavity-Fighting Lollipop – Biologists Identified a New Way in Which Bacteria Hijack Healthy Cells

The Beneficial Phytochemicals in Vegetables Help Us Lead Healthy Lives

Posted on January 28, 2012  Comments (2)

If I don’t pay attention, I won’t eat enough vegetables. Even when I do pay attention I still don’t eat enough (but get closer). Paying attention to what you eat is important for your health.

Some tips from the video.

  • Eat a wide variety of vegetables, to get the benefits each offers.
  • Cruciferous vegetables have cancer preventing benefits and enhancing the immune system. Vegetables in this category include broccoli and cauliflower.
  • Berries also have chemicals that aid in the prevention of cancer.

Related: Healthy Diet, Healthy Living, Healthy Weight – Eat food. Not too much. Mostly plants. – Are Our Vegtables Less Nutritious?

Fields Medalist Tim Gowers Takes Action To Stop Cooperating with Anti-Open Science Cartel

Posted on January 26, 2012  Comments (0)

The Fields medal is know as the Nobel of mathematics. Tim Gowers was awarded the Fields medal in 1998 for contributions to functional analysis, making extensive use of methods from combinatorial theory. Tim Gowers is currently the Rouse Ball Professor of Mathematics at Cambridge University. He posted recently on his decision to stop supporting (with his actions, such as submitting paper and reviewing papers) the anti-open-science behavior of Elsevier (a particularly aggressive anti-open-science publisher that also has very bad pricing practices).

Elsevier — my part in its downfall

One method that they have for getting away with it is a practice known as “bundling”, where instead of giving libraries the choice of which journals they want to subscribe to, they offer them the choice between a large collection of journals (chosen by them) or nothing at all. So if some Elsevier journals in the “bundle” are indispensable to a library, that library is forced to subscribe at very high subscription rates to a large number of journals, across all the sciences, many of which they do not want. (The journal Chaos, Solitons and Fractals is a notorious example of a journal that is regarded as a joke by many mathematicians, but which libraries all round the world must nevertheless subscribe to.) Of course, given that libraries have limited budgets, this often means that they cannot subscribe to journals that they would much rather subscribe to, so it is not just libraries that are harmed, but other publishers, which is of course part of the motivation for the scheme.
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Elsevier supports many of the measures, such as the Research Works Act, that attempt to stop the move to open access. They also supported SOPA and PIPA and lobbied strongly for them.
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I also don’t see any argument at all against refusing to submit papers to Elsevier journals.

So I am not only going to refuse to have anything to do with Elsevier journals from now on, but I am saying so publicly. I am by no means the first person to do this, but the more of us there are, the more socially acceptable it becomes

Good for him. All we need is for more and more scientists, mathematicians and engineers to support open science with thier actions and open science will be the way things are. It is as simple as that. The outdated business practices of the old journals will die. Either the existing publishers will finally give up on their extremely outdated practices or they will be replaced.

Related: The Architecture of Access to Scientific Knowledge – Merck and Elsevier Publish Phony Peer-Review Journal – The Future of Scholarly Publication (2005) – Science Journal Publishers Stay Stupid (2007) “It is time for the scientific community to give up on these journals and start looking to move to work with new organizations that will encourage scientific communication and advancement”

How Lysozyme Protein in Our Tear-Drops Kill Bacteria

Posted on January 24, 2012  Comments (0)

A disease-fighting protein in our teardrops has been tethered to a tiny transistor, enabling UC Irvine scientists to discover exactly how it destroys dangerous bacteria. The research could prove critical to long-term work aimed at diagnosing cancers and other illnesses in their very early stages.

Ever since Nobel laureate Alexander Fleming found that human tears contain antiseptic proteins called lysozymes about a century ago, scientists have tried to solve the mystery of how they could relentlessly wipe out far larger bacteria. It turns out that lysozymes have jaws that latch on and chomp through rows of cell walls like someone hungrily devouring an ear of corn.

“Those jaws chew apart the walls of the bacteria that are trying to get into your eyes and infect them,” said molecular biologist and chemistry professor Gregory Weiss, who co-led the project with associate professor of physics & astronomy Philip Collins.

The researchers decoded the protein’s behavior by building one of the world’s smallest transistors – 25 times smaller than similar circuitry in laptop computers or smartphones. Individual lysozymes were glued to the live wire, and their eating activities were monitored.

“Our circuits are molecule-sized microphones,” Collins said. “It’s just like a stethoscope listening to your heart, except we’re listening to a single molecule of protein.”

It took years for the UCI scientists to assemble the transistor and attach single-molecule teardrop proteins. The scientists hope the same novel technology can be used to detect cancerous molecules. It could take a decade to figure out but would be well worth it, said Weiss, who lost his father to lung cancer.

“If we can detect single molecules associated with cancer, then that means we’d be able to detect it very, very early,” Weiss said. “That would be very exciting, because we know that if we treat cancer early, it will be much more successful, patients will be cured much faster, and costs will be much less.”

The project was sponsored by the National Cancer Institute and the National Science Foundation. Co-authors of the Science paper are Yongki Choi, Issa Moody, Patrick Sims, Steven Hunt, Brad Corso and Israel Perez.

Related: full press release – Why ‘Licking Your Wounds’ Works – How Bleach Kills Bacteria – Algorithmic Self-Assembly

Royal Society Journal Embraces Open Access

Posted on January 23, 2012  Comments (0)

Royal Society journal archive made permanently free to access

The Royal Society…journal archive – which includes the first ever peer-reviewed scientific journal – has been made permanently free to access online.

Around 60,000 historical scientific papers are accessible via a fully searchable online archive, with papers published more than 70 years ago now becoming freely available.
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reasures in the archive include Isaac Newton’s first published scientific paper, geological work by a young Charles Darwin, and Benjamin Franklin’s celebrated account of his electrical kite experiment.

The move is being made as part of the Royal Society’s ongoing commitment to open access in scientific publishing.

Good for them. Slowly more and more are realizing clinging to old fashion publishing models are contrary to promoting science and scientific literacy.

Related: 340 Years of Royal Society Journals Online – Britain’s Royal Society Experiments with Open Access (2006) – 8-10 Year Olds Research Published in Royal Society Journal

Study of the Colony Collapse Disorder Continues as Bee Colonies Continue to Disappear

Posted on January 19, 2012  Comments (1)

I can understand why people get complacent. We have a pretty remarkable run of science and technology finding solutions for whatever peril we face.

Also, quite often, future risks are over-blown. Then, people get habituated to reading ominous predictions, followed by a future doesn’t seem to reach those dramatic predictions. But this is a risky pattern to just expect – that no matter what we will figure out some way to avoid the consequences.

Risks actually do come true. The obvious result of overfishing, just as predicted, has resulted in collapses of fish populations over and over creating great hardship for those who had fallen victim to that prediction. If people don’t vaccinate themselves (and their kids) we will have ever increasing numbers of deaths and sickness. If we fail to use anti-biotics is a long term sustainable way, our actions will result in many deaths.

I am not sure why we find it so easy to ignore the evidence of bad consequences but we do. Partially I would imagine that as problems begin to be manifest countermeasures take affect. So in the fishing example, many people leave that line of work and so the numbers in the industry after a collapse, who are suffering in the present, are reduced. Still I find it odd how easily we ignore the risks in the future.

I do understand if there are short term benefits to ignoring the risks (or pretending they don’t exist): so you have fisherman that don’t want to take steps in advance to avoid collapse. Or you have industries and politicians that want to pretend ignoring global warming is a strategy to avoid the consequences. Or you have parents that say, well today we don’t have many risks of sicknesses people get vaccinated against (yes, because people have been vaccinated – if you stop vaccinating your children they we get to experience the avoidable pain and suffering).

I have been following the honeybee colony collapse disorder for several years (see the end of the posts for links to posts from 2006 – 2010, like this one The Study of Bee Colony Collapses Continues from 2007). It is a great example of the scientific inquiry process. It is messy and confusing and full of studies that have trouble finding what the actually causes are or what solutions will work.

There are occasionally mentions of how devestating things could get if the trend continues. In fact stories that seem so devestating that they just don’t seem real. surely either that won’t happen or if it started to some countermeasure would be found to deal with the problem and avoid the most severe consequences. That is basially how I have felt about it. But that is not because of some scientific understanding but just a feeling that hey that couldn’t really happen. Well that isn’t exactly solid evidence that it can’t.

Honeybee problem nearing a ‘critical point’

In addition to continued reports of CCD — a still somewhat mysterious phenomenon in which entire bee colonies literally disappear, alien-abduction style, leaving not even their dead bodies behind — bee populations are suffering poor health in general, and experiencing shorter life spans and diminished vitality. And while parasites, pathogens, and habitat loss can deal blows to bee health, research increasingly points to pesticides as the primary culprit.
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farmers use these chemicals to protect their crops from destructive insects, but in so doing, they harm other insects essential to their crops’ production — a catch-22 that Hackenberg said speaks to the fact that “we have become a nation driven by the chemical industry.” In addition to beekeeping, he owns two farms, and even when crop analysts recommend spraying pesticides on his crops to kill an aphid population, for example, he knows that “if I spray, I’m going to kill all the beneficial insects.” But most farmers, lacking Hackenberg’s awareness of bee populations, follow the advice of the crop adviser — who, these days, is likely to be paid by the chemical industry, rather than by a state university or another independent entity.

I believe this is the latest advise of the Unites States Department of Agriculture (though their web site doesn’t make it nearly as obvious as it should that this is in fact the current advice – the document seems to indicate it is but if someone were to say no, that is outdated, it wouldn’t be hard to believe)

Continue reading →

Staphylococcal Food Poisoning

Posted on January 17, 2012  Comments (0)

I pretty much don’t get sick, which is great. Twice in the last month I got something like food poisoning (which is more sickness than I get most years). So I looked online for some information on what might cause my symptoms and how fast it is possible for the onset of symptoms.

Staphylococcal food poisoning is a gastrointestinal illness. It is caused by eating foods contaminated with toxins produced by Staphylococcus aureus. It seems like a possible culprit. My guess is the onset for me has been within 2 hours (or it was a coincidence. That fast of an onset seems rare (based on my limited research).

The United States Center for Disease Control says symptoms can last 24-48 hours. For me symptoms came and went within 15 minutes. Rapid fever and “heat” feeling everywhere, diarea, gone. No more than 15 minutes from start to finish. I really find it very odd how I can feel so weird quickly and then just as quickly it is all gone.

The bacterium can also be found in unpasteurinzed milk and cheese products. Staphylococcus is salt tolerant and can grow in salty foods like ham. As the bacterium multiplies in food, it produces toxins that can cause food poisoning. Staphylococcal toxins are resistant to heat and cannot be destroyed by cooking. Foods at highest risk of producing toxins from Staphylococcus aureus are those that are made by hand and require no cooking. Some examples of foods that have caused staphylococcal food poisoning are sliced meat, puddings, pastries and sandwiches. The foods may not smell bad or look spoiled in order to produce the toxins.

Unrefrigerated or improperly refrigerated meats, potato and egg salads, cream pastries are possible paths to the food poisoning. I suspect ghee, in my case.

The CDC says that staphylococcal toxins are fast acting, sometimes causing illness in as little as 30 minutes after eating.contaminated foods., but symptoms usually develop within one to six hours. Patients typically experience several of the following: nausea, retching, vomiting, stomach cramps, and diarrhea. The illness cannot be passed to other people and it typically lasts for one day, but sometimes it can last up to three days. In a small minority of patients the illness may be more severe. They don’t seem to agree it can disappear in 15 minutes, otherwise it seems a possible cause.

Of course being essentially total ignorant about this stuff I could also be completely off base. I find this interesting though so I am doing some more reading.

I think it would be nice if the CDC would put links on pages to other causes with similar symptoms. Wouldn’t that be a good usability feature?

Related: What You Need to Know About Foodborne Illness-Causing Organisms – Tracking the Ecosystem Within Us – Healthy Diet, Healthy Living, Healthy Weight – The Man Who Unboiled an Egg

Science Matters

Posted on January 10, 2012  Comments (0)

Google is a company that values science. The Google magazine, Think Quarterly, has an interesting interview with Professor Rolf-Dieter Heuer, Director General of CERN: The Light Fantastic. He discusses, among other things the recent experimental results that seemed to indicate neutrinos traveling faster than the speed of light:

“The world is moving so quickly that people are asking for answers when we don’t have the question yet,” Professor Heuer admits. Even worse, in this economic climate, “They are asking, ‘Why do we need science? We should take care of our immediate problems first.’ But if people in past decades had thought that way, we wouldn’t have the society we have today. Everything depends on science – this is what we need to communicate to people. I think it’s working because the general public is realizing not just how fascinating science can be, but what can come out of science in terms of knowledge and, at some stage, the betterment of society.”

The answer, perhaps, lies in rediscovering the roots of science – in using the FTL [Faster than Light] breakthrough to go back to the future. “I want to encourage the interest of artists in our work,” the professor reveals. “After all, at the very beginning, art and science started as the same thing. Bring them back together and the public might say, ‘Oh, this is how you can see science.’ Once people start talking about it, you have progress in understanding and accepting it.”

Related: Larry Page on How to Change the World (2008) – Science Serving Society, Speech Australian Minister for Innovation – Energy Secretary Steve Chu and Google CEO Speak On Funding Science Research

20th Annual US First Robotics Competition

Posted on January 8, 2012  Comments (2)

If you have a child, niece, nephew, grandchild… who you haven’t been able to convince about the wonders of science maybe the starts on this promo (Justin Timberlake, Snoop Dogg, Justin Bieber…) can help convince them. If you want to convince your grandparents science is cool, then maybe they will like the cameos by Steven Tyler and Bono :-P This is an effort being pushed by will.i.am (Black Eyed Peas) and Dean Kamen (US First Founder) to promote science and engineering. Since most politicians don’t seem interested in promoting and supporting science anymore maybe musicians can help turn things around.

I have written about US First, it is a great program. It engages children in learning by taping their curiosity and desire to create. I think learning this way is much more natural and fun and affective than what we have too often in schools today. I know I was bored quite often but was told the adults knew best. Well know I am an adult and I think I was right back then: our education system can, and should be greatly improved. Until then, US First, and similar, programs give kids a good environment for learning that keeps their desire to learn intact.

The video spot was created to promote a TV show commemorating the 20th annual US FIRST Robotics competition. Watch the TV show:

Related: Lunacy, FIRST Robotics Challenge 2009 – For Inspiration and Recognition of Science and Technology (FIRST), 2005 post – Test it Out, Experiment by They Might Be Giants – Botball 2009 Finals

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