Posts about Science

Massive Blast of Measles Vaccine Wiped Out Cancer In Study

Unfortunately these stories are not uncommon but the hoped for follow through of practical solutions that work at all are rare. But we keep learning and while the breakthroughs based on these news stories is rare we do keep finding new and better methods to cope with health issues.

Mayo Clinic trial: Massive blast of measles vaccine wipes out cancer

Stacy Erholtz was out of conventional treatment options for blood cancer last June when she underwent an experimental trial at the Mayo Clinic that injected her with enough measles vaccine to inoculate 10 million people.

The 50-year-old Pequot Lakes mother is now part of medical history.

The cancer, which had spread widely through her body, went into complete remission and was undetectable in Erholtz’s body after just one dose of the measles vaccine, which has an uncanny affinity for certain kinds of tumors.

Erholtz was one of just two subjects in the experiment and the only one to achieve complete remission. But the experiment provides the “proof of concept” that a single, massive dose of intravenous viral therapy can kill cancer by overwhelming its natural defenses, according to Dr. Stephen Russell, a professor of molecular medicine who spearheaded the research at Mayo.

Researchers have known for decades that viruses can be used to destroy cancer. They bind to tumors and use them as hosts to replicate their own genetic material; the cancer cells eventually explode and release the virus. Antiviral vaccines that have been rendered safe can produce the same effects and can also be modified to carry radioactive molecules to help destroy cancer cells without causing widespread damage to healthy cells around the tumors. The body’s immune system then attacks any remaining cancer that carries remnants of the vaccine’s genetic imprint.

Mayo started out giving patients 1 million infectious units and gradually cranked up the dosage — but it didn’t work until Erholtz and another patient were injected with 100 billion infectious units, he said.

While the treatment worked in Erholtz, whose tumors were primarily in her bone marrow, the results weren’t sustained in the second patient, whose tumors were largely confined to her leg muscles. Russell said researchers need to study how the nature of the tumor affects the lethality of the virus.

One challenge of health research on fatal health conditions is that the experimentation with people is usually limited to people that have no available options left from the approved treatments. So, in general they are very sick. And the great complexity of dealing with human immune systems, the variation in the disease and in people create a very difficult research environment. Thankfully we have many great scientists dedicated to finding new treatments.

Related: Virus Kills Breast Cancer Cells in LaboratoryVirus Engineered To Kill Deadly Brain TumorsUsing Bacteria to Carry Nanoparticles Into CellsWebcast of a T-cell Killing a Cancerous Cell

Science Explained: How Cells React to Invading Viruses

This illustrated webcast introduces the microscopic arsenal of weapons and warriors that play a role in the battle for your health.

TED education has been putting out some good videos which is a wonderful thing to see. It is wonderful to let people everywhere (kids and adults) that are interested in learning (and that have internet access) can learn about the world around us. Traditional educational institutions have not done much with this opportunity to broaden their impact.

The video looks at the cells reaction to a virus infiltrating the cell.

Related: Cells AliveScience Explained: Cool Video of ATP Synthase, Which Provides Usable Energy to UsThis webcast is packed with information on the makeup and function of eukaryotic (animal) cellsCool Animation of a Virus Invading a Person’s BodyCell Aging and Limits Due to TelomeresWebcast of a T-cell Killing a Cancerous Cell

How Healthy Is Squid for Us?

I try to eat healthfully, especially when I can tweak what I eat to gain a health advantage. I know fish have good qualities. I live in Malaysia now and squid (called sotong here) is often available. I often prefer squid to fish here as the fish use here are often fairly small with bones to deal and not much meat for the effort (it is great sometimes but I am often lazy).

photo of squid dinner

Sambal Sotong (squid) with bitter gourd (home delivery). Very tasty. The bitter gourd is very bitter, but a few bites are ok.

So I looked online for some details, it wasn’t as easy I would have hoped. The Shellfish Association of Great Britain offered a good overview.

They say 100g of raw squid (pre cooking weight) provides about 200% of Vitamin B12, 100% of Selenium, 80% of Copper, 50% of Vitamin B6, 35% of Vitamin E, 34% of Phosphorous, 30 % of Protein, 20% of Niacin, 10% of B1 (Thiamin), 8% of Potassium, 10% of Magnesium, 14% of Zinc.

From various sources online it seems there are 92 calories in 100 grams of Squid with a calorie breakdown of 72% protein, 14% fat and 14% carbs.

From the Heart Association of Australia “omega-3s are found primarily in oily fish, such as Atlantic and Australian salmon, blue-eye trevalla, blue mackerel, gem fish… Other fish such as barramundi, bream or flathead, and seafood such as arrow squid, scallops and mussels, are also good sources of omega-3… To reduce the risk of heart disease, the Heart Foundation recommends that Australian adults consume about 500 milligrams of omega-3 (marine source) every day.”

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Alternative Career Paths Attract Many Women in Science Fields

Instead of following traditional paths, women are using their science, technology, engineering, and math degrees to create new careers.

There are plenty of women out there engaged in traditional jobs in science, technology, engineering, and math, but many are forging novel, interdisciplinary, STEM-based careers that blur categories and transcend agenda.

Because women have traditionally been excluded from these disciplines, and because their fresh eyes allow them to make connections between fields, many women are launching careers, and even entire industries, based on a flexible and creative definition of what it means to be a scientist, artist, or engineer. K-12 schools have done a particularly poor job of integrating study across STEM fields and encouraging creativity and interdisciplinary connections.

We continue to teach science, technology, and math in isolation, as if they have little to do with one another. This sort of compartmentalized approach runs counter to what we know about effective learning: Students need to be able to connect content knowledge and concepts to real-world applications in order to develop mastery and passion for a subject.

The challenge for anyone seeking to forge a brave new path through STEM careers, particularly ones that involve interdisciplinary study and practice, is the challenge of job stability. Kendall Hoyt, professor of technology and biosecurity at Thayer School of Engineering explained, “Interdisciplinary career paths are easier to create than they are to sustain, because there is not an established career trajectory and evaluation system.”

The challenge of how to maximize the opportunities for those interested in careers in science, technology, engineering and math is important to all economies. There are difficulties in doing this and so continued focus on this area is good. My personal belief is we focus too much on the gender issue. Yes, we should reduce discrimination. I think we have done well but still have further to go.

Most of the suggested changes in how things should be done help women and also plenty of men that are turned off by the old way of doing things.

I also think we need to be careful in how we use data. Clamoring about discrepancies in a field with far more men (say physics) while not doing the same about a field with far more women (say psychology) is questionable to me. I don’t believe that any field that isn’t 50% male and 50% female is evidence that we need to fix the results so they are 50% each.

I believe we should provide everyone the opportunity to pursue the interests they have. They must perform to earn the right to continue. And we don’t want to waste potential with foolish barriers (for women, minorities or men). But if we do so and certain fields attract more women and others attract more men I think we can waste our effort by being too worried that certain fields are problematic.

If we are concerned it should be based on data and looking at the real world situation. In the coming decades my guess is women will exceed men in careers in many science disciplines (engineering still has fairly high male bias overall though some field, such as bio-engineering are already majority female graduates). It starts with education and women are already the majority of undergraduate degrees in science and engineering overall. And in many disciplines they dominate.

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Goats Excel at Learning and Remembering a Complex Tasks

I like research showing animals using intelligence that seems advanced, for example: Crow Using a Sequence of Three ToolsInsightful Problem Solving in an Asian ElephantBird-brains smarter than your average apeTropical Lizards Can Solve Novel Problems and Remember the SolutionsPigeon Solves Box and Banana Problem.

I also like open access science, and this has both: Goats excel at learning and remembering a highly novel cognitive task

The majority of trained goats (9/12) successfully learned the task quickly; on average, within 12 trials. After intervals of up to 10 months, they solved the task within two minutes, indicating excellent long-term memory. The goats did not learn the task faster after observing a demonstrator than if they did not have that opportunity. This indicates that they learned through individual rather than social learning.”

The individual learning abilities and long-term memory of goats highlighted in our study suggest that domestication has not affected goat physical cognition. However, these cognitive abilities contrast with the apparent lack of social learning, suggesting that relatively intelligent species do not always preferentially learn socially. We propose that goat cognition, and maybe more generally ungulate cognition, is mainly driven by the need to forage efficiently in harsh environments and feed on plants that are difficult to access and to process, more than by the computational demands of sociality. Our results could also explain why goats are so successful at colonizing new environments.

The experiment was done with domesticated goats. I also learned this from the article, which I didn’t know before:

Domestication is known to strongly affect brain size. Consistent reductions in brain size relative to body size, as well as in brain size parts, have occurred in many domestic species.

Related: Orangutan Attempts to Hunt Fish with SpearFriday Fun: Bird Using Bait to FishPhoto of Fish Using a Rock to Open a Clam

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Refusal to Follow Scientific Guidance Results in Worms Evolving to Eat Corn Designed to Kill The Worms

An understanding of natural selection and evolution is fundamental to understanding science, biology, human health and life. Scientists create wonderful products to improve our lives: vaccines, antibiotics, etc.; if we don’t use them or misuse them it is a great loss to society.

There is also great value in genetic enhanced seeds and thus plants (through natural human aided processes such as breeding and providing good genetic material over a wide area – distances that would not be covered naturally, at least not in a time that helps us much). Genetic Modified Organisms (GMO) food, in which we tinker with the genes directly also holds great promise but has risks, especially if we forget basic scientific principles such as biodiversity.

Voracious Worm Evolves to Eat Biotech Corn Engineered to Kill It

First planted in 1996, Bt corn quickly became hugely popular among U.S. farmers. Within a few years, populations of rootworms and corn borers, another common corn pest, had plummeted across the midwest. Yields rose and farmers reduced their use of conventional insecticides that cause more ecological damage than the Bt toxin.

By the turn of the millennium, however, scientists who study the evolution of insecticide resistance were warning of imminent problems. Any rootworm that could survive Bt exposures would have a wide-open field in which to reproduce; unless the crop was carefully managed, resistance would quickly emerge.

Key to effective management, said the scientists, were refuges set aside and planted with non-Bt corn. Within these fields, rootworms would remain susceptible to the Bt toxin. By mating with any Bt-resistant worms that chanced to evolve in neighboring fields, they’d prevent resistance from building up in the gene pool.

But the scientists’ own recommendations — an advisory panel convened in 2002 by the EPA suggested that a full 50 percent of each corn farmer’s fields be devoted to these non-Bt refuges — were resisted by seed companies and eventually the EPA itself, which set voluntary refuge guidelines at between 5 and 20 percent. Many farmers didn’t even follow those recommendations.

Using extremely powerful tools like GMO requires society to have much better scientific literacy among those making decisions than any societies have shown thus far. The failure of our governments to enforce sensible scientific constraints on such use of genetic engineering creates huge risks to society. It is due to this consistent failure of our government to act within sensible scientific constraints that causes me to support efforts (along with other reasons – economic understanding – the extremely poor state of patent system, risk reduction…) to resist the widespread adoption of GMO, patenting of life (including seeds and seeds produced by seeds).

Wonderful things are possible. If we grow up and show a long term track record of being guided by scientific principles when the risks of not doing so are huge then I will be more supportive of using tactics such as GMO more easily. But I don’t see us getting their anytime soon. If anything we are much less scietifically minded and guided than we were 50 years ago: even while we bask in the glorious wonders science has brought us on a daily basis.

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Explaining the Higgs Boson Particle Again

comic illustration explaining the Higgs-boson particle

Excerpt from Piled Higher and Deeper by Jorge Cham – go see the entire illustration.

Related: 5% of the Universe is Normal Matter, What About the Other 95%?At the Heart of All MatterThe god of small thingsCERN Pressure Test FailureNinja ProfessorsFriday Fun, CERN Version

Math Education Results Show China, Singapore, Korea and Japan Leading

The most comprehenvise comparison of student achievement in math and science around the globe undertaken by the Organisation for Economic Co-operation and Development (OECD). The 2012 Program for International Student Assessment (PISA) focuses on math understanding of 15 year olds (the 2014 report will focus on science). The 2009 report focused on the results of science education student achievement around the globe.

2012 results for the math portion (rank – country – mean score)(I am not listing all countries):

  • 1 – Singapore – 573
  • 2 – Korea – 554
  • 3 – Japan – 536
  • 5 – Switzerland – 531
  • 6 – Netherlands – 523
  • 7 – Estonia – 521
  • 8 – Finland – 519
  • 9 – Canada – 518
  • 12 – Germany – 514
  • 24 – UK – 494 (this is also the OECD average)
  • 34 – USA – 481
  • 49 – Malaysia – 421
  • 50 – Mexico – 413

All 34 OECD member countries and 31 partner countries and economies participated in PISA 2012, representing more than 80% of the world economy. Portions of China participated and did very well including Shanghai-China (highest mean score of 613 points – if you ranked that as a country, I ignored these “regional results” in the ranks I shown here), Hong Kong-China (561, 3rd if including countries and regions together), Chinese Taipei [Taiwan] (560, 4th), Macao-China (538, 6th).

Boys perform better than girls in mathematics in 38 out of the 65 countries and economies that participated in PISA 2012, and girls outperform boys in 5 countries.

Related: Playing Dice and Children’s NumeracyNumeracy: The Educational Gift That Keeps on GivingMathematicians Top List of Best OccupationsThe Economic Consequences of Investing in Science EducationCountry H-index Ranking for Science PublicationsEconomic Strength Through Technology Leadership

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How Wolves Changed the Yellowstone Ecosystem

A great short video explaining the dramatic changes to the Yellowstone ecosystem with the re-introduction of wolves. Even the rivers changed.

Related: Light-harvesting Bacterium Discovered in YellowstoneFishless FutureThe Sea Otter storyYellowstone Youth Conservation Corps Polar Bears Playing with HuskiesCurious Cat travel photos of Yellowstone National Park

Why Don’t All Ant Species Replace Queens in the Colony, Since Some Do

My response to: There are other species of ants that do replace the queen, so why did some species not do this?

Basically the method they evolved copes well with losing the queen. Out of various ways of dealing with having a dominant Queen some may lead to replacement if she dies.

There are lots of examples of method is very effective at creating lots of successful offspring but happens to be less than ideal in some situations. Natural selection is pretty amazing and awesome at creating effective genes but we certainly can look at the results sometimes and see improvements that would be useful.

Likely if losing the queen was very common a good way of dealing with that would be found (or that species would be disadvantaged and at risk). If the queen happens to evolve to being very reliable coping with her death becomes less important. If they produce lots of useful offspring but have a less than ideal method of coping with their home colony losing her it is entirely sensible to imagine that species could flourish.

I would imagine species with queens that had shorter lifespans, that invested more in the home colony, that were less effective at setting up new colonies… would be more likely to have better queen replacement strategies/results.

Related: Ants, Ants, AntsE.O. Wilson: Lord of the AntsAmazonian Ant Species is All Female, Reproduces By CloningRoyal Ant GenesHuge Ant Nest

Country H-index Ranking for Science Publications

The SCImago Journal and Country Rank provides journal and country scientific indicators developed from the information contained in the Scopus database (this site also lets you look at these ranking by very specific categories (I think 313 categories), for example biotechnology #1 USA, #2 Germany, #3 UK, #4 Japan, #9 China or Theoretical Computer Science #1 USA, #2 UK, #3 Canada, #6 China). I posted about this previously (in 2008 and 2011) and take a look at the updated picture in this post.

I like looking at data and country comparisons but in doing so it is wise to remember this is the results of a calculation that is interesting but hardly definative. We don’t have the ability to have exact numbers on haw the true scientific knowledge output by countries are. I think you can draw the conclusion that the USA is very influential, and along with other data make the case even that the USA is the leading scientific publication center.

The table shows the top 6 countries by h-index and then some others I chose to list.

Country h-index 2007
h-index
% of World
Population
% of World GDP total cites
USA 1,389 793     4.4%   22.4% 129,540,193
United Kingdom 851 465  0.9  3.4 31,393,290
Germany 740 408  1.2  4.7  25,848,738
France 681 376  0.9  3.6  5,795,531
Canada 658 370  0.5  2.5 15,696,168
Japan 635 372  1.8  8.2 20,343,377
Additional countries of interest
16) China 385 161  19.2  11.3  11,253,119
19) South Korea 343 161    .7  1.8  4,640,390
22) Brazil 305 148  2.8  3.1 3,362,480
24) India 301 146  17.6  2.5 4,528,302

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