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Introduction to Fractional Factorial Designed Experiments

Posted on June 10, 2013  Comments (1)

Scientific inquiry is aided by sensible application of statistical tools. I grew up around the best minds in applied statistics. My father was an eminent applied statistican, and George Box (the person in the video) was often around our house (or we were at his). Together they wrote Statistics for Experimenters (along with Stu Hunter, not related to me) the bible for design of experiments (George holds up the 1st edition in the video).

The video may be a bit confusing without at least a basic idea of factorial designed experiments. These introductory videos, by Stu Hunter, on Using Design of Experiments to Improve Results may help get you up to speed.

This video looks at using fractional factorials to reduce the number of experiments needed when doing a multifactor experiment. I grew up understanding that the best way to experiment is by varying multiple factors at the same time. You learn much quicker than One Factor At a Time (OFAT), and you learn about interactions (which are mainly lost in OFAT). I am amazed to still hear scientists and engineers talk about OFAT as a sensible method or even as the required method, but I know many do think that way.

To capture the interactions a full factorial requires an ever larger number of experimental runs to be complete. Assessing 4 factors requires 16 runs, 6 would require 64 and 8 would require 256. This can be expensive and time consuming. Obviously one method is to reduce the number of factors to experiment with. That is done (by having those knowledgable about the process include only those factors worth the effort), but if you still have, for example, 8 very important factors using a fractional factorial design can be very helpful.

And as George Box says “What you will often find is that there will be redundant factors… and don’t forget about those redundant factors. Knowing that something doesn’t matter is almost as important as knowing what does.” If you learn a factor isn’t having an affect you may be able to save money. And you can eliminate varying that factor in future experiments.

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Webcast: Examining the Scientific Basis Around Exercise and Diet Claims

Posted on May 19, 2013  Comments (0)

Tim Noakes is the Director of UCT/MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Science, University of Cape Town and Professor, Discovery Health Chair of Exercise and Sports Science, University of Cape Town.

Tim examines some questions on science and exercise and health in the webcast. He shows the problem with drinking too much during exercise and the correlation of hospital admissions correlated to the sport drinks marketing and changing of the official drinking guidelines. He also discusses the outdated ideas related to lactic acid and muscles.

He is currently studying the science of food and human health and is skeptical of low fat health claims: “No evidence that dietary fat is related to heath disease.” He is certainly more knowledgable than I but I would still be cautious of completely accepting that premise. It does seem to me there is lots of evidence that claims of causation between eating a high fat diet and heart disease were too strong (many other factors were critical – such as weight, exercise, genetics, unsaturated fat v. saturated fat…).

Tim Noaks: “50% of what we teach is wrong; the problem is we don’t know which 50% it is. Our job as educated people is to spend our lifetime trying to figure out which 50% is which. Until it is disproven accept that for which the evidence appears solid and logical and is free of covert or overt conflicts of interest, because unfortunately industry is driving what you believe in many many things. But don’t ever dismis lightly that for which there is credible evidence… and there is such clear evidence the diets we are eating are horrendous.”

As I have said before, scientific literacy is critical to allow us to make those judgements about what is credible evidence and what are outright lies, foolish claims or highly suspicious claims tainted by conflicts of interest.

Related: Can You Effectively Burn Calories by Drinking Cold Water? – Static Stretching Decreases Muscle Strength – Lack of Physical Activity Leads to 5.3 Million Early Deaths a Year – Science Continues to Explore Causes of Weight Gain – Study Finds Obesity as Teen as Deadly as Smoking

Science Facts About Cats

Posted on April 4, 2013  Comments (0)

Related: Domestic Cats Remain Successful Predators – Backyard Wildlife: Mountain Lion – Friday Fun: Cats and Kids with iPads

Quick Webcast With a Few Interesting Science Facts

Posted on January 7, 2013  Comments (1)

Interesting facts: I didn’t know that we require 13 minerals or that alcoholic beverages contain amounts of all the minerals we need. An amazing fact: the average person walks the equivalent of 3 times around the earth in a lifetime.

The minerals we need (and the recommended daily amount)

Calcium – 1,200 mg
Magnesium – 320 mg
Phosphorus – 700 mg
Potassium – 4.7 g
Sodium – ?
Chloride?

trace amounts needed
Cobalt (as Vitamin B12) – 2.4 mcg
Copper – 1,156 mcg
Iodine – 150 mcg
Iron – 8 mg
Manganese – 1.8 mg
Niacin – 14 mg
Riboflavin – 1.1 mg
Selenium – 55 mcg
Thiamin – 1.1 mg
Zinc – 8 mg
Chromium?, Molybdenum? Fluoride?

Frankly, in my quick looks around the internet I am not sure what they base the claim we need only 13 minerals on. It seems we need trace amounts of more minerals – did they just ignore those not in alcohol?

I couldn’t find good sources confirming just what minerals are needed. Many list some minerals but don’t list others. I am not really sure what the answer is. I am glad I seem to somehow get whatever I need just by eating somewhat healthfully. It is pretty cool we get these things that way. Of course if we didn’t our ancestors wouldn’t have survived to create descendants that finally became us – as they had a much harder time than me (who can just go the restaurant and grocery store and get all sorts of wonderful food).

Related: the atoms that make up the human body, were created in the crucible of stars – Science Explained: Cool Video of ATP Synthase, Which Provides Usable Energy to Us – Video of Young Richard Feynman Talking About Scientific Thinking – Scientific Illiteracy Leads to Failure to Vaccinate Which Leads to Death

Physics Lesson

Posted on December 9, 2012  Comments (0)

Related: Brian Cox Lecture on Science and Quantum Mechanics – Scientific Inquiry Process Finds More Evidence Supporting Einstein’s Theory of Gravity – Friday Fun: CERN Version

Why is the Sky Dark at Night?

Posted on October 11, 2012  Comments (8)

The answer isn’t quite as simple as it seems. I find the wording in the video a bit confusing.

The point I believe, is that the sky is dark instead of light. But not that the brightness would be huge (so for example, you couldn’t necessarily read my book outside just by starlight). The light would be very faint, it is just that it would be lightish instead of blackish, due to the reasons explained (redshift etc.). At least that is my understanding.

Related: Why is it Colder at Higher Elevations? – Why Does the Moon Appear Larger on the Horizon? – Why is the Sky Blue? – Why Wasn’t the Earth Covered in Ice 4 Billion Years Ago – When the Sun was Dimmer

Capuchin Monkeys Don’t Like Being Paid Less

Posted on October 9, 2012  Comments (6)

Quite a fun video. Frans de Waal shows us a task he gave Capuchin monkeys to see if they responded to a sense of fairness. See the rest of the talk.

Frans de Waal is a Dutch primatologist and ethologist. He is the Charles Howard Candler professor of Primate Behavior in the Emory University psychology department in Atlanta, Georgia. His research centers on primate social behavior, including conflict resolution, cooperation, inequity aversion, and food-sharing.

Related: Rats Show Empathy-driven Behavior – Capuchin Monkeys Using Stone Tools – Dolphin Delivers Deviously for Rewards – overpaid executives harm companies – Crow Using a Sequence of Three Tools

Science Explained: Cool Video of ATP Synthase, Which Provides Usable Energy to Us

Posted on September 17, 2012  Comments (2)

This webcast shows animations of ATP synthase structure and the mechanism for synthesizing ATP. Biology is incredibly cool. Too bad they didn’t have stuff like this when I was in school, instead biology was mainly about memorizing boring lists of stuff.

ATP (adenosine tri-phosphate) transports chemical energy within cells. When one of the phosphates is released by ATP energy is given off (and ATP becomes ADP (adenosine di-phosphate) + Pi (inorganic phosphate). And then the synthase structure can then turn it back into ATP to be used again.

The human body, which on average contains only 250 grams of ATP, turns over its own body weight equivalent in ATP each day.

Related: ATP synthase lecture notes University of Illinois – Webcast on the makeup and function of eukaryotic cells – Science Explained: Photosynthesis – Video showing malaria breaking into cell

The Science Behind Hummingbird Flight

Posted on August 24, 2012  Comments (3)

Aerodynamics of the hovering hummingbird

Hummingbirds and insects have evolved for sustained hovering flight from vastly different ancestral directions, and their distinct phylogenies underlie the differences in their aerodynamic styles. In all other birds—and, presumably, hummingbird ancestors—the downstroke provides 100% of weight support during slow flight and hovering. Given that many birds possess the mass-specific power (using anaerobic metabolism) to hover for short periods, the selective pressure on hummingbird ancestors was probably for increased efficiency (resulting in stiff wings with greatly simplified
kinematics), and an upstroke muscle (the supracoracoideus) that makes the recovery stroke rapid, while contributing enough to the hovering power requirements to allow the downstroke muscle (the pectoralis) to operate within its aerobic limits.

In other words, this pseudosymmetrical wingbeat cycle is good enough, and although hummingbirds do not exhibit the elegant aerodynamic symmetry of insects, natural selection rewards ‘good enough’ as richly as it does our aesthetic ideals

Related: Praying Mantis Attacks Hummingbird – Friday Fun: Crow Sledding, Flying Back Up and Sledding Down Again – Bird Using Bait to Fish

Great Webcast Explaining the Digestive Systems

Posted on August 11, 2012  Comments (0)

You will learn things like why it is so important to chew your food well (increase the surface area for enzymes to get at the food). Our bodies also have adapted to provide a huge surface area for the digestive system to work; the small intestine alone has a surface area of 250 square meters (larger than the size of most apartments). Your small intestine is 4.5 to 10.5 meters long.

Related: Staphylococcal Food Poisoning – Energy Efficiency of Digestion – Tracking the Ecosystem Within Us – Waste from Gut Bacteria Helps Host Control Weight

The Chemistry of Fireworks

Posted on July 4, 2012  Comments (2)

The video features John A. Conkling, Ph.D., who literally wrote the book on fireworks — he is the author of The Chemistry of Pyrotechnics.

The earliest documentation of fireworks dates back to 7th century China.

A Syrian named Hasan al-Rammah wrote of rockets, fireworks, and other incendiaries, using terms that suggested he derived his knowledge from Chinese sources, such as his references to fireworks as “Chinese flowers”.

Chinese fireworks began to gain popularity around the mid-17th century.

Related: Cooking with Chemistry, Hard Candy – The Chemistry of Cooking – Video of Briggs-Rauscher Oscillating Chemical Reaction

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