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August 25, 2008

Patent Gridlock is Blocking Developing Lifesaving Drugs

How patent gridlock is blocking the development of lifesaving drugs by Michael Heller, Forbes

Since a 1980 Supreme Court decision allowing patents on living organisms, 40,000 dna-related patents have been granted. Now picture a drug developer walking into an auditorium filled with dozens of owners of the biotech patents needed to create a potential lifesaving cure. Unless the drugmaker can strike a deal with every person in the room, the new drug won’t be developed.

Nicholas Naclerio, who used to head the BioChip Division at Motorola , told Scientific American, “If we want to make a medical diagnostic with 40 genes on it, and 20 companies hold patents on those genes, we may have a big problem.”

And it’s not just drugs we’re losing. Today anything high tech–banking, semiconductors, software, telecom–demands the assembly of innumerable patents. Innovation has moved on, but we’re stuck with old-style ownership that’s easy to fragment and hard to put together. This debacle’s only upside is that assembling fragmented property is one of the great entrepreneurial and political opportunities of our era.

This is a critical problem I have written about before. The broken patent system is a serious problem that needs to be fixed.

Related: The Effects of Patenting on Science - Patent Policy Harming USA, and the world - Patenting Life is a Bad Idea - The Differences Between Culture and Code - Innovation and Creative Commons - The Value of the Public Domain - The Patent System Needs to be Significantly Improved - Are Software Patents Evil?

July 1, 2008

Protecting the Food Supply

A few weeks ago we posted about Tracking Down Tomato Troubles as another example of the challenges of scientific inquiry. Too often, in the rare instances that science is even discussed in the news, the presentation provides the illusion of simple obvious answers. Instead it is often a very confusing path until the answers are finally found (posts on scientific investigations in action). At which time it often seems obvious what was going on. But to get to the solutions we need dedicated and talented scientists to search for answers.

Now the CDC is saying tomatoes might not be the source of the salmonella after all: CDC investigates possible non-tomato salmonella sources.

Federal investigators retraced their steps Monday as suspicions mount that fresh unprocessed tomatoes aren’t necessarily causing the salmonella outbreak that has sickened hundreds across the USA.

Three weeks after the Food and Drug Administration warned consumers to avoid certain types of tomatoes linked to the salmonella outbreak, people are still falling ill, says Robert Tauxe with the Centers for Disease Control and Prevention. The latest numbers as of Monday afternoon were 851 cases, some of whom fell ill as recently as June 20, says Tauxe, deputy director of the CDC’s division of foodborne diseases.

The CDC launched a new round of interviews over the weekend. “We’re broadening the investigation to be sure it encompasses food items that are commonly consumed with tomatoes,” Tauxe says. If another food is found to be the culprit after tomatoes were recalled nationwide and the produce industry sustained losses of hundreds of millions of dollars, food safety experts say the public’s trust in the government’s ability to track foodborne illnesses will be shattered.

“It’s going to fundamentally rewrite how we do outbreak investigations in this country,” says Michael Osterholm of the Center for Infectious Disease Research and Policy at the University of Minnesota. “We can’t let this investigation, however it might turn out, end with just the answer of ‘What caused it?’ We need to take a very in-depth look at foodborne disease investigation as we do it today.”

I am inclined to believe the FDA is not enough focused on food safety. Perhaps we are not funding it enough, but we sure are spending tons of money on something so I can’t believe more money needs to be spent. Maybe just fewer bills passed (that the politicians don’t even bother to read) with favors to special interests instead of funding to support science and food safety. Or perhaps we are funding enough (though I am skeptical of this contention) and we just are not allowing food safety to get in the way of what special interests want (so we fund plenty for FDA to have managed this much better, to have systems in place that would provide better evidence but they are either prevented from doing so or failed to do so). I am inclined to believe special interests have more sway in agencies like (NASA, EPA, FDA…) than the public good and scientific openness - which is very sad. And, it seems to me, politicians have overwhelmingly chosen not to support more science in places like FDA, CDC, NIH… while increasing federal spending in other areas dramatically.

Related: USDA’s failure to protect the food supply - FDA May Make Decision That Will Speed Antibiotic Drug Resistance - Food safety proposal: throw the bums out - The A to Z Guide to Political Interference in Science

May 31, 2008

Saving Fermilab

Fermilab was once the premiere particle physics research lab. It is still a very important research lab. But, I have said before, other countries are the ones making the larger efforts lately to invest in science and technology centers of excellence that the US was making in the 1960’s and 1970’s: Economic Strength Through Technology Leadership, Investing in Technology Excellence, etc..

I have also said that the past success of the US has left it in a still very strong position. For example, the anonymous donor that saved Fermilab with a $5 million donation likely benefited from the successful investments in science centers of excellence in the past (few countries - maybe 30, can rely on large donations from wealthy individuals, to sustain centers of excellence and I don’t think any approach what the USA has now - Howard Hughes Medical Institute, Standford, MIT…).

Excellent post on the the saving of Fermilab, To the person who saved Fermilab: Thank You.:

The facility has recently seen financial difficulties which have resulted in the layoffs of research staff and dramatic cuts in experiments. The world class research facility has been left to scrape together funds to pay the bills and has even had to auction off equipment and ask staff members to take pay cuts just to keep the lights on in the laboratories.

Fermilab also has an illustrious history of achievements in the field of supercomputer development and parallel processing. Fermilab has been on the forefront of applying supercomputing to physics research and is one of the top supercomputing centers of the world. Fermilab has claimed the world’s most powerful supercomputer on multiple occasions - although the title is rarely held long by any system due to the continuous advancements in computing. In recent years, Fermilab has been a leader in the development of “lattice” supercomputing systems and has developed methods for efficiently utilizing the power of multiple supercomputers in different locations through more [efficient] distribution practices.

To some, the construction of the Large Hadron Collider at CERN may seem to reduce the importance of Fermilab’s capabilities, but this is not at all the case. Although the LHC may take the title for the overall size and energy levels of a particle accelerator, Fermilab remains a uniquely capable particle physics research institution. Though less powerful, the Tevatron is able to operate for longer periods of time than the LHC and will likely require less downtime for maintenance, allowing for greater access and numerous types of research activities.

Related: CERN Pressure Test Failure - posts on funding science research - Matter to Anti-Matter 3 Trillion Times a Second - Google Investing Huge Sums in Renewable Energy - Gates Foundation and Rotary Pledge $200 Million to Fight Polio - Washington Waste - Washington Paying Out Money it Doesn’t Have - Proposal to Triple NSF GFRP Awards and the Size of the Awards by 33%

May 28, 2008

Quake Lake Danger

Quakes lakes risk ’slurry tsunami’

This month’s 7.9 magnitude tremor spawned 34 so-called quake lakes, according to the International Association of Hydraulic Engineering and Research expert. The vast pools of water were created when the earthquake triggered landslides down plunging valleys, clogging rivers and turning them into fast-rising lakes. Twenty-eight quake lakes are at risk of bursting, according to Chinese state media agency Xinhua. But the one at Tangjiashan - on the Jianjiang river above the town of Beichuan - is the most precarious.

The delicate, tortuous work involves heavy machinery gingerly shifting debris from the dam, and engineers blasting dynamite to carefully punch holes in the mountain of rubble and soil - although experts warn this risks further destabilising the structure. Nearly 160,000 people in the disaster zone have already been evacuated in case the Tangjiashan quake lake bursts.

Troops and engineers are racing to carve a 500 metre (1,640 ft) channel out of the landscape and divert the water towards the Fujiang river. They aim to complete the giant sluice and begin draining the 300 million cubic metre capacity lake within 10 days. “Once the water begins to flow over the top of the dam there’s nothing you can do to stop it,” said Dr Alex Densmore, of Durham University’s Institute of Hazard and Risk Research.

Little wonder then that Premier Wen Jiabao says he regards draining the swelling quake lakes at China’s ground zero as the nation’s most urgent task.

Related: Quake Lifts Island Ten Feet Out of Ocean - Civil Engineers: USA Infrastructure Needs Improvement - China’s Technology Savvy Leadership - Megaflood Created the English Channel

May 26, 2008

Solar Thermal in Desert, to Beat Coal by 2020

Google, Chevron Build Mirrors in Desert to Beat Coal With Solar

Along a dusty two-lane highway in California’s Mojave Desert, 550,000 mirrors point skyward to make steam for electricity. Google Inc., Chevron Corp. and Goldman Sachs Group Inc. are betting this energy will become cheaper than coal.

The 1,000-acre plant uses concentrated sunlight to generate power for as many as 112,500 homes in Southern California. Rising natural gas prices and emissions limits may make solar thermal the fastest-growing energy source in the next decade, say backers including Vinod Khosla, the founder of computer maker Sun Microsystems Inc. Costs for the technology will fall below coal as soon as 2020, the U.S. government estimates.

“Solar thermal can provide a substantial amount of our power, more than 50 percent,” says Khosla

Nine solar thermal plants built in the California desert from 1985 to 1991 still operate, with Juno Beach, Florida-based FPL Group Inc. running seven. They have combined capacity of 354 megawatts, enough to power 230,000 Southern California homes. Development slowed when Congress eliminated tax credits for alternative energy in the early 1990s. Laws put in place in 2005 give solar investors a 30 percent tax credit.

Great progress is being made adding wind and solar capacity. And the increasing oil prices are encouraging much faster adoption of these technologies. The promise of widespread adoption is rapidly becoming a reality.

Related: Solar Energy: Economics, Government and Technology - Wind Power Potential to Produce 20% of Electricity Supply by 2030 - Google Investing Huge Sums in Renewable Energy - Solar Tower Power Generation

May 25, 2008

Germany Bans Chemicals Linked to Bee Deaths

Germany bans chemicals linked to honeybee devastation

Germany has banned a family of pesticides that are blamed for the deaths of millions of honeybees. The German Federal Office of Consumer Protection and Food Safety (BVL) has suspended the registration for eight pesticide seed treatment products used in rapeseed oil and sweetcorn.

The move follows reports from German beekeepers in the Baden-Württemberg region that two thirds of their bees died earlier this month following the application of a pesticide called clothianidin. “It’s a real bee emergency,” said Manfred Hederer, president of the German Professional Beekeepers’ Association. “50-60% of the bees have died on average and some beekeepers have lost all their hives.” Tests on dead bees showed that 99% of those examined had a build-up of clothianidin.

The company says an application error by the seed company which failed to use the glue-like substance that sticks the pesticide to the seed, led to the chemical getting into the air.

Related: The Study of Bee Colony Collapses Continues - Bye Bye Bees - Scientists Search for Clues To Bee Mystery

May 21, 2008

USA Science Losing Ground

I have written about the continued decline in the relative position of science in the USA compared to the rest of the world: Engineering the Future Economy - Economic Strength Through Technology Leadership - The Best Research Universities - U.S. Slipping on Science - Diplomacy and Science Research - Scientists and Engineers in Congress. The USA continues to act as though the rewards for scientific excellence automatically go to the USA. That isn’t the case and as many other countries make smart investments in scientific centers of excellence the USA chooses to do very little.

Has U.S. Science Lost Its Competitive Edge?

Craig Barrett, former CEO of Intel, delivered perhaps the most stinging indictment of the current political system. “There will be winners and losers, and the losers are the ones who insist on looking backwards,” said Barrett. “We continue to subsidize 19th century technology–like in the $290 billion farm bill–rather than the 21st century technologies that will allow us to remain competitive. We’re fat, dumb, and happy.”

hefty increases at three science agencies–the National Science Foundation, the Department of Energy Office of Science, and the National Institute of Standards and Technology. Last summer, legislation that incorporates many of those recommendations became law. But funding for most of the initiatives has yet to materialize.

Speakers repeatedly pointed to those anemic budgets as evidence that politicians haven’t realized the threats to American preeminence in science posed by the rest of the world.

As I have said many times the consequences of failing to take sensible action today will be large. Science and engineering centers of excellence have been a very important factor in the economic success of the USA.

May 15, 2008

Wind Power Potential to Produce 20% of Electricity Supply by 2030

Wind energy has been growing tremendously. In 2000 there were 2,500 megawatts (MW) of installed wind capacity in the United States. By the end of 2007, the U.S. installed capacity exceeded 16,000. A recent Department of Energy report sees the potential to provide up to 20% of our nation’s electrical supply via wind power by 2030.

Related: Global Wind Power Installed Capacity - Electricity Savings - Google Investing Huge Sums in Renewable Energy

May 11, 2008

Running Out of Fish

I have posted before about the overfishing problems: Fishless Future - SelFISHing - Chinook Salmon Vanish Without a Trace. Here is an emotional article on the problem - How the world’s oceans are running out of fish

Ninety years of industrial-scale exploitation of fish has, he and most scientists agree, led to ‘ecological meltdown’. Whole biological food chains have been destroyed.

In 2002, the year an EU report revealed that the Senegalese fish biomass had declined 75 per cent in 15 years, Brussels bought rights for four years’ fishing of tuna and bottom-dwelling fish on the Senegal coasts, for just $4m a year. In 2006, access for 43 giant EU factory fishing vessels to Mauritania’s long coastline was bought for £24.3m a year. It’s estimated that these deals have put 400,000 west African fishermen out of work; some of them now take to the sea only as ferrymen for desperate would-be migrants to the Canary Islands and Europe.

Protecting up to 40 per cent of the world’s oceans in permanent refuges would enable the recovery of fish stocks and help replenish surrounding fisheries. ‘The cost, according to a 2004 survey, would be between £7bn and £8.2bn a year, after set-up. But put that against the £17.6bn a year we currently spend on harmful subsidies that encourage overfishing.’

The Newfoundland cod fishery, for 500 years the world’s greatest, was exhausted and closed in 1992, and there’s still no evidence of any return of the fish. Once stocks dip below a certain critical level, the scientists believe, they can never recover because the entire eco-system has changed.
May 1, 2008

Presidential Award for Top Science and Math Teachers

Top Science and Math Teachers Receive Presidential Award

For the 2007 awards, 99 middle school and high school math and science teachers are receiving this recognition. In the citation from the president, winners are commended “for embodying excellence in teaching, for devotion to the learning needs of the students, and for upholding the high standards that exemplify American education at its finest.”

Each winner receives a $10,000 award from NSF, as well as a trip for two to Washington, D.C., for a week of celebratory events and professional development activities.

Among the activities during that week are a day with scientists and science educators at NSF; meetings with members of Congress and federal agency leadership; and a reception and dinner at the U.S. Department of State featuring guest speaker Dorothy Metcalf-Lindenburger, a NASA Astronaut-Mission Specialist.

Related: Presidential Award for Excellence in Mathematics and Science Teaching - Einstein Fellowship for Teachers - NSF Graduate Teaching Fellows in K-12 Education - The Importance of Science Education - Education Resources Directory for Science and Engineering

April 27, 2008

Wheat Rust Research

By increasing the production of wheat it is said Norman Borlaug has saved more lives than anyone else who ever lived, for which he was awarded the 1970 Nobel Peace Prize. See his New York Times opinion piece: Stem Rust Never Sleeps

Today, wheat provides about 20 percent of the food calories for the world’s people. The world wheat harvest now stands at about 600 million metric tons.

In the last decade, global wheat production has not kept pace with rising population, or the increasing per capita demand for wheat products in newly industrializing countries. At the same time, international support for wheat research has declined significantly. And as a consequence, in 2007-08, world wheat stocks (as a percentage of demand) dropped to their lowest level since 1947-48. And prices have steadily climbed to the highest level in 25 years.

The new strains of stem rust, called Ug99 because they were discovered in Uganda in 1999, are much more dangerous than those that, 50 years ago, destroyed as much as 20 percent of the American wheat crop. Today’s lush, high-yielding wheat fields on vast irrigated tracts are ideal environments for the fungus to multiply, so the potential for crop loss is greater than ever.

If publicly financed international researchers move together aggressively and systematically, high-yielding replacement wheat varieties can be developed and made available to farmers before stem rust disease becomes a global epidemic.

The Bush administration was initially quick to grasp Ug99’s threat to American wheat production. In 2005, Mike Johanns, then secretary of agriculture, instructed the federal agriculture research service to take the lead in developing an international strategy to deal with stem rust. In 2006, the Agency for International Development mobilized emergency financing to help African and Asian countries accelerate needed wheat research.

But more recently, the administration has begun reversing direction. The State Department is recommending ending American support for the international agricultural research centers that helped start the Green Revolution, including all money for wheat research. And significant financial cuts have been proposed for important research centers, including the Department of Agriculture’s essential rust research laboratory in St. Paul.

This shocking short-sightedness goes against the interests not only of American wheat farmers and consumers but of all humanity. It is tantamount to the United States abandoning its pledge to help halve world hunger by 2015.

Related: Diplomacy and Science Research - Five Scientists Who Made the Modern World - 2004 Medal of Science Winners - U.S. Slipping on Science

April 14, 2008

ASU Science Studio Podcasts

Science Studio offers podcasts by the Arizona State University School of Life Sciences with professors discussing science; it is another excellent source of science podcasts. Podcasts include:

  • Of Whales, Fish and Men: Managing Marine Reserves - With 90% of the world’s fisheries in a state of collapse, the questions around establishing marine reserves, monitoring, and species/stock recovery take on critical dimensions. But how do decision-makers, stakeholders, and the public formulate effective conservation policies; ones right for their community?
  • Biology on Fire - Regents’ Professor, Mac Arthur Fellow, author and a world’s expert on fire and fire ecology Stephen Pyne talks about how fire, its use, misuse, and its biological nature have shaped our world, before and because of man, and learn how policies of the past still reverberate in our present, in Arizona and globally.
  • Giant Insects: Not just in B movies - Professor Jon Harrison sheds light on the evolution of his scientific career and nature’s biggest order: arthropods. How big is big? In the Paleozoic, cockroaches were the size of housecats and dragonflies the size of raptors.
  • Special Feature: Building a science career - One of the most highly cited ecologists in the world, Jane Lubchenco trod her own unique path to success. In this live recording with the Association for Women in Science, she explains how assertiveness, the art of negotiation, and knowing the currency for promotion and tenure can make the difference between achieving balance between family and career and dropping out the leaky academic pipeline that leads to advancement.

These podcasts are great way to use the internet to serve the mission of universities: to educate. And a great way to promote science.

Related: Lectures from the Stanford Linear Accelerator Center - UC-Berkeley Course Videos - Science Podcast Libraries - Communicating Science to the Public

April 11, 2008

NASA Science Website

The NASA Science Mission Directorate sponsors scientific research, and develops and deploys satellites and probes in collaboration with NASA’s partners around the world to answer fundamental questions requiring the view from and into space. SMD seeks to understand the origins, evolution, and destiny of the universe and to understand the nature of the phenomena that shape it. SMD also seeks to understand:

* the nature of life in the universe and what kinds of life may exist beyond Earth;
* the solar system, both scientifically and in preparation for human exploration; and
* the Sun and Earth, changes in the Earth-Sun system, and the consequences of the Earth-Sun relationship for life on Earth.

Maybe, for this site NASA actually listened to the engineers: as this site works rather than making false claims about the visitor’s browser. The site includes content specifically targeted at teachers, students, researchers and the general public.

Related: Great Self Portrait - Boiling Water in Space - Mars Rovers Getting Ready for Another Adventure

March 27, 2008

Solar Energy: Economics, Government and Technology

An American Solar Opportunity Gets Shipped Abroad

The project will pour $1 billion into utility-scale photovoltaic solar farms that will directly feed power into a country’s electrical grid. The installations will range from fewer than 2 MW to up to 50 MW, while a single farm could cover hundreds and hundreds of acres.

They’ll be installed in Europe. In Asia. And maybe even in America too, one day. Why not now? Because AES wants to sow its solar seeds in only those countries that offer the most “attractive tariffs.” That eliminates the US from the list of potentials, immediately. And it gives countries like Germany, Spain, Italy and South Korea the clear advantage. They all have can’t-beat national incentives for solar developers.

It’s one of the sad facts of Washington’s incoherent clean energy policy these days. How can a country lure in clean energy projects when there are far more appealing offers elsewhere?

Government actions impact economic decisions. It will likely take more than 10 years to have good data on what government investments pay off in the energy sector. But I would say it is a pretty good bet to invest in technology such as: solar, geothermal, wind… Countries that create global centers of excellence in these areas are likely to benefit greatly. The only question I think is that many countries are smart enough to see the benefits and so likely many countries will try.

Any time many actors pursue the same economic strategy there is the risk that the payoff is diluted with so many others having done the same thing. Still the reason so many countries have adopted the strategy of developing centers of excellence in science, engineering and technology is that it is such a good idea. The USA has a problem in that we are spending more than we produce on luxuries today so there is much less available to invest compared to other countries (and compared to 40 years ago).

Related: Global Installed Capacity of Wind Power - Invest in Science for a Strong Economy - Science, Engineering and the Future of the American Economy - China challenges scientific research dominance of USA, Europe and Japan - Green Energy in Canada

March 24, 2008

Science Serving Society - Speech Austalian Minister for Innovation

Kim Carr, Minister for Innovation, Australia, speech to the National Press Club of Australia: Science meets Parliament

When societies invest in science, they are investing in their own future. They are entitled to expect a fair return on that investment.

They’re entitled to know we are using the country’s intellectual and technical capacity to deliver outcomes that matter to them – stronger communities, more good jobs, a cleaner environment, better public services, a richer culture, greater security for themselves and their children. Everybody here knows the rules of professional scientific conduct – think independently, put emotion aside, reject received authority, be faithful to the evidence, communicate openly.

These are good rules – rules I wholeheartedly endorse – but there’s one more I’d like to add – remember your humanity. Remember you’re part of a wider society – one that you have a special ability and therefore a special duty to serve. This doesn’t just apply in the physical sciences, but in the humanities and social sciences as well. When I say science I mean knowledge in all its forms.

Related: Engineering Economic Benefits - Authors of Scientific Articles by Country - Economic Strength Through Technology Leadership - Science and Engineering in Global Economics - Aussies Look to Finnish Innovation Model - Invest in Science for a Strong Economy
(more…)

March 20, 2008

NASA You Have a Problem

Go to NASA’s web site. Use the security settings that are most intelligent to use, the NoScript plugin for Firefox, and NASA makes this bold pointy haired boss statement at the top of every page:

“There’s a problem with your browser or settings.

Your browser or your browser’s settings are not supported. To get the best experience possible, please download a compatible browser. If you know your browser is up to date, you should check to ensure that javascript is enabled.”

Well no, there is no problem with my browser settings. And I am using the latest version of the most popular browser. 0 for 2 phb. What you mean to say is: I am so lame I hired someone who designed our web site so it fails to work properly without javascript enabled.

Jeez, get someone who know how to program a web site that just works. Any marginally competent individual can have your site work for any modern browser and then add in extra features people can take advantage using javascript, or flash or whatever extra things you want. It is amazing that an agency that is suppose to know about technology can do such a lame job of producing a web site. They do manage to provide good content for their web site (probably the content is provided by engineers while some phb decides they know what is best for the web site code).

Related: Astronaut and Earth - Usability Failures at the Royal Society Web Site - NSF Usability Failure - Webcasts by Chemistry and Physics Nobel Laureates

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