MIT Engineers Design New Type of Nanoparticle for Vacines

Posted on February 22, 2011  Comments (6)

MIT engineers have designed a new type of nanoparticle that could safely and effectively deliver vaccines for diseases such as HIV and malaria. The new particles, described in the Feb. 20 issue of Nature Materials, consist of concentric fatty spheres that can carry synthetic versions of proteins normally produced by viruses. These synthetic particles elicit a strong immune response – comparable to that produced by live virus vaccines – but should be much safer, says Darrell Irvine, author of the paper and an associate professor of materials science and engineering and biological engineering.

Such particles could help scientists develop vaccines against cancer as well as infectious diseases. In collaboration with scientists at the Walter Reed Army Institute of Research, Irvine and his students are now testing the nanoparticles’ ability to deliver an experimental malaria vaccine in mice.

Vaccines protect the body by exposing it to an infectious agent that primes the immune system to respond quickly when it encounters the pathogen again. In many cases, such as with the polio and smallpox vaccines, a dead or disabled form of the virus is used. Other vaccines, such as the diphtheria vaccine, consist of a synthetic version of a protein or other molecule normally made by the pathogen.

When designing a vaccine, scientists try to provoke at least one of the human body”™s two major players in the immune response: T cells, which attack body cells that have been infected with a pathogen; or B cells, which secrete antibodies that target viruses or bacteria present in the blood and other body fluids.

For diseases in which the pathogen tends to stay inside cells, such as HIV, a strong response from a type of T cell known as “killer” T cell is required. The best way to provoke these cells into action is to use a killed or disabled virus, but that cannot be done with HIV because it”™s difficult to render the virus harmless.

To get around the danger of using live viruses, scientists are working on synthetic vaccines for HIV and other viral infections such as hepatitis B. However, these vaccines, while safer, do not elicit a very strong T cell response. Recently, scientists have tried encasing the vaccines in fatty droplets called liposomes, which could help promote T cell responses by packaging the protein in a virus-like particle. However, these liposomes have poor stability in blood and body fluids.

Irvine, who is a member of MIT”™s David H. Koch Institute for Integrative Cancer Research, decided to build on the liposome approach by packaging many of the droplets together in concentric spheres. Once the liposomes are fused together, adjacent liposome walls are chemically “stapled” to each other, making the structure more stable and less likely to break down too quickly following injection. However, once the nanoparticles are absorbed by a cell, they degrade quickly, releasing the vaccine and provoking a T cell response.

read the full press release

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6 Responses to “MIT Engineers Design New Type of Nanoparticle for Vacines”

  1. Kris
    February 23rd, 2011 @ 3:41 am

    I’m still confused how you can vaccinate cancer which isn’t technically a disease. My hope in this area is for genetically engineered viruses.

  2. suji george
    February 24th, 2011 @ 2:23 pm

    ondering whether such type of vaccines can be targeted to different organs as depending upon the cell type lipid composition of cell membrane varies. So by varying the liposome composition targeted results can be achieved.

  3. Cat Allergy Vaccine Created » Curious Cat Science and Engineering Blog
    April 2nd, 2011 @ 8:48 am

    The researchers took one protein (molecule) that cats secrete on their fur which causes the majority of allergic problems…

  4. emlak haberleri
    April 21st, 2011 @ 7:36 pm

    Im still confused how you can vaccinate cancer which isn”™t technically a disease. My hope in this area is for genetically engineered viruses.

  5. Cancer Vaccines » Curious Cat Science and Engineering Blog
    April 25th, 2011 @ 7:51 am

    […] reader commented on a previous post (MIT Engineers Design New Type of Nanoparticle for Vacines) asking about how vaccines can fight cancer. Preventative vaccines can build up immune response to […]

  6. Alanya Emlak
    July 22nd, 2013 @ 3:56 pm

    reader commented on a previous post (MIT Engineers Design New Type of Nanoparticle for Vacines) asking about how vaccines can fight cancer.Im still confused how you can vaccinate cancer which isn”™t technically a disease. My hope in this area is for genetically engineered viruses.ondering whether such type of vaccines can be targeted to diffeeleasing the vaccine and provoking a T cell response.rent organs as depending upon the cell ty

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