Posts about cool

NASA Biocapsules Deliver Medical Interventions Based Upon What They Detect in the Body

Very cool innovation from NASA. The biocapsule monitors the environment (the body it is in) and responds with medical help. Basically it is acting very much like your body, which does exactly that: monitors and then responds based on what is found.

The Miraculous NASA Breakthrough That Could Save Millions of Lives

The Biocapsules aren’t one-shot deals. Each capsule could be capable of delivering many metred doses over a period of years. There is no “shelf-life” to the Biocapsules. They are extremely resilient, and there is currently no known enzyme that can break down their nanostructures. And because the nanostructures are inert, they are extremely well-tolerated by the body. The capsules’ porous natures allow medication to pass through their walls, but the nanostructures are strong enough to keep the cells in one place. Once all of the cells are expended, the Biocapsule stays in the body, stable and unnoticed, until it is eventually removed by a doctor back on Earth.

Dr. Loftus [NASA] thinks we could realistically see wildspread usage on Earth within 10 to 15 years.

The cells don’t get released from the capsule. The cells inside the capsule secrete therapeutic molecules (proteins, peptides), and these agents exit the capsule by diffusion across the capsule wall.

NASA plans to use the biocapsules in space, but they also have very promising uses on earth. They can monitor a diabetes patient and if insulin is needed, deliver it. No need for the person to remember, or give themselves a shot of insulin. The biocapsule act just like out bodies do, responding to needs without us consciously having to think about it. They can also be used to provide high dose chemotherapy directly to the tumor site (thus decreasing the side effects and increasing the dosage delivered to the target location. Biocapsules could also respond to severe allergic reaction and deliver epinephrine (which many people know have to carry with them to try and survive an attack).

It would be great if this were to have widespread use 15 years from now. Sadly, these innovations tend to take far longer to get into productive use than we would hope. But not always, so here is hoping this innovation from NASA gets into ourselves soon.

Related: Using Bacteria to Carry Nanoparticles Into CellsNanoparticles With Scorpion Venom Slow Cancer SpreadSelf-Assembling Cubes Could Deliver MedicineNanoengineers Use Tiny Diamonds for Drug Delivery

Webcast of a T-cell Killing a Cancerous Cell

Very cool. Very good job by University of Cambridge to make this kind of material available openly online. I find this kind of video amazing. Every day you body has this going on all day long. How amazing.

This is what it looks like when cancer gets smacked down by a T cell

This was shot by University of Cambridge medical researcher Alex Ritter, and is 92 times faster than real time.

Cells of the immune system protect the body against pathogens. If cells in our bodies are infected by viruses, or become cancerous, then killer cells of the immune system identify and destroy the affected cells. Cytotoxic T cells are very precise and efficient killers. They are able to destroy infected or cancerous cells, without destroying healthy cells surrounding them.

Related: Using Bacteria to Carry Nanoparticles Into CellsHow Cells AgeVideo showing malaria breaking into cellSynthetic Biologists Design a Gene that Forces Cancer Cells to Commit Suicide

Cool Robot Locomotion: Transforms from Wheeled to Walking For Stairs and Rough Terrain

This is a very cool engineering solution. Wheeled locomotion is very efficient on the right terrain. This transformation lets the robot switch to climb stairs and handle rough terrain very nicely. A team of mechanical engineers at National Taiwan University built this energy-efficient leg-wheel hybrid mobile robot. From their description:

Compared to most hybrid platforms, which have separate mechanisms and actuators for wheels and legs, our leg-wheel hybrid mobile robot, Quattroped, uses a “transformation mechanism” that deforms a specific portion of the body to act as a wheel or a leg. From a geometrical point of view, a wheel usually has a circular rim and a rotational axis located at the center of the rim. The rim contacts the ground and the rotational axis connects to the robot body at a point hereafter referred to as the “hip joint.” In general, with wheeled locomotion on flat ground, the wheel rotates continuously and the ground-contact point of the wheel is located directly below the hip joint with a fixed distance. In contrast, in legged locomotion the leg moves in a periodic manner and there is no specific geometrical configuration between the hip joint and the ground-contact point; thereby, the relative position of the legs varies frequently and periodically during locomotion.

Based on this observation, shifting the hip joint out of the center of the circular rim and changing the continuous rotation motion to other motion patterns implies the locomotion switches from wheeled mode to legged mode. This motivated us to design a mechanism that directly controls the relative position of the circular rim with respect to the hip joint so it can generate both wheeled and legged motions. Because the circular rim is a 2-dimensional object, the most straightforward method to achieve this goal is to add a second degree of freedom (DOF) that can adjust the relative position of the hip joint to the center of the circular rim along the radial direction. The motions of the two DOFs are also orthogonal to each other. In addition, the same set of actuation power can be efficiently used in both wheeled and legged modes.

Related: Big Dog, The Robotic Dog (2008)Robots That Start as Babies Master Walking Faster Than Those That Start as AdultsSelf Re-assembling RobotsSoft Morphing Robot (soft tissue)

Nature Uses Stem Cells from Fetus to Repair Health of Mother

Science shows us so many amazing things. Scientists have learned mice use stem cells from the fetus to repair damage to the mother in the event of things like heart attacks. And there is evidence people do the same thing. Very cool. Nature beat us to the idea of using stem cells to treat health problems.

Helpful Mouse Fetuses Naturally Send Stem Cells to Mom to Fix Her Damaged Heart

When the scientists examined the female mice’s heart tissue two weeks after the heart attacks, they found lots of glowing green tissue—cells that came from the fetus—in the mom’s heart. Mice who had heart attacks had eight times as many cells from the fetus in their hearts as mice who hadn’t had a heart attack did, meaning the high volume of fetal cells was a response to the heart attack.

What’s more, the embryo’s stem cells had differentiated into various types of heart tissue, including cardiomyocytes, the rhythmically contracting muscle cells that produce a heartbeat.

The hearts of two women who suffered from severe heart weakness were later found to contain cells derived from the cells of a male fetus years after they gave birth to their sons.

The same thing seems to hold true for other organs. When pregnant women have damage in other organs, including the brain, lung, and liver, earlier studies have shown, fetal cells show up there, too.

It makes sense for a fetus to try and aid the mother but it is amazing the evolution found such solutions. Given how many challenges the fetus creates for the mother giving some benefits can help increase the odds of a health birth.

Related: Researchers Explain How Rotifers Thrive Despite Forgoing SexMaking Embryonic Stem CellsStructure and Function of RibosomeWhy People Often Get Sicker When They’re Stressed

Amazing New Light Field Camera: Adjust Focus After You Take the Picture

The cool Lytro light field camera lets you adjust the focus after the picture is taken. Wow what a surprise the company is located in Mountain View, California. Oh wait, no that isn’t a surprise. Those of us in the USA should thank our lucky stars for having Silicon Valley in our country.

The Lytro will be available in early 2012 starting at $399 (a 8 GB model able to hold up to 350 images) and $499 for a $499 16 GB model able to hold 750 images.

The camera does take 3d images. That feature will be enabled via a software update after the initial release.

Related: Rare Saharan Cheetahs Photographed with Camera TrapAwesome Camera for Your CatCurious Cat Gadget BlogAmazon’s Android Tablet, the Kindle FireQubits Construction Toy

Driving Via Direct Signals from the Brain

Last year we learned of Google’s Self Driving Car, which is actually making great progress in the real world (cool). And a few years ago I wrote about Toyota’s wheelchair you control with your mind. Now Nissan is looking at cars that you drive aided by accessing brain signals.

This idea is a bit scary to me, the self driving car is less so. But it is great to see us pushing the engineering boundaries forward. It is such a shame that the huge economic failures in the USA, Europe and Japan are rightly grabbing much of the attention these days. If we just reduced the waste and corruption in the political and financial systems it would allow us to take more joy is the great time we do for awesome engineering breakthroughs. Still, if we can try to block out those painful economic realities, these types of breakthroughs are really cool.

The webcast shows the work of the Artificial Intelligence Group of the Freie Universität Berlin in Germany (BrainDriver).

Related: Nissan’s Cars Will Read Your MindResearching Direct Brain Interfaces for Text EntryWave Disk Engine Could Increase Efficiency 5 Times

And Nissan is collaborating with the École Polytechnique Fédérale de Lausanne in Switzerland (EPFL) on a car that uses your brain signals (along with signals the computer gets via its own sensors) to aid in driving.
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Insightful Problem Solving in an Asian Elephant

Another example of very cool animal behavior. This Asian Elephant, seemed to consider the problem, devise a solution and then go get a stool to reach food that could not be reached without a tool.

Insightful Problem Solving in an Asian Elephant

The “aha” moment or the sudden arrival of the solution to a problem is a common human experience. Spontaneous problem solving without evident trial and error behavior in humans and other animals has been referred to as insight. Surprisingly, elephants, thought to be highly intelligent, have failed to exhibit insightful problem solving in previous cognitive studies. We tested whether three Asian elephants (Elephas maximus) would use sticks or other objects to obtain food items placed out-of-reach and overhead. Without prior trial and error behavior, a 7-year-old male Asian elephant showed spontaneous problem solving by moving a large plastic cube, on which he then stood, to acquire the food. In further testing he showed behavioral flexibility, using this technique to reach other items and retrieving the cube from various locations to use as a tool to acquire food. In the cube’s absence, he generalized this tool utilization technique to other objects and, when given smaller objects, stacked them in an attempt to reach the food. The elephant’s overall behavior was consistent with the definition of insightful problem solving. Previous failures to demonstrate this ability in elephants may have resulted not from a lack of cognitive ability but from the presentation of tasks requiring trunk-held sticks as potential tools, thereby interfering with the trunk’s use as a sensory organ to locate the targeted food.

Further inspired by Köhler’s chimpanzee studies, in experiment 4 we conducted 8 additional sessions to investigate whether Kandula would stack items to reach food. For these sessions, the baited branches were hung at a height that could be reached by stacking three butcher block cutting boards or by the use of other objects. In addition, the elephant was given sticks and other enrichment items. Kandula first touched several items and then moved two items, a plastic disk and a block under the suspended branches, placing one front foot on each in an unsuccessful attempt to reach for the branch. He solved the problem in an unexpected novel manner, moving and standing on the object closest in size to the absent cube, a large ball. Standing on unstable platforms such as this had not been previously observed. He repeated this behavior 9 times during this session. During the session’s last minutes, Kandula picked up a block ~2 m from the food and placed it directly on top of a block that he placed under the food in a previous attempt. He stood on the stacked blocks and attempted to reach the food but was unsuccessful. He stacked two blocks again in the second and sixth sessions but each time his trunk was several inches from the food.

This is very cool research. I do wonder why they didn’t provide more videos (and in a more user-friendly format than .mov files). I made them available via YouTube.

It seems like a very interesting area to have more experiments with more elephants (and continuing to work with Kandula: he seems to be very curious elephant, good for him).

Related: Orangutan Attempts to Hunt Fish with SpearBird Using Bait to Catch FishCrows Transferring Their Understanding to Novel ProblemCapuchin Monkeys Using Stone ToolsFighting Elephant Poaching With SciencePhoto of Fish Using a Rock to Open a Clam
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MIT Scientists Find New Drug That Could Cure Nearly Any Viral Infection

New drug could cure nearly any viral infection

The drug works by targeting a type of RNA produced only in cells that have been infected by viruses. “In theory, it should work against all viruses,” says Todd Rider, a senior staff scientist in Lincoln Laboratory‘s Chemical, Biological, and Nanoscale Technologies Group who invented the new technology.

There are a handful of drugs that combat specific viruses, such as the protease inhibitors used to control HIV infection, but these are relatively few in number and susceptible to viral resistance.

Rider drew inspiration for his therapeutic agents, dubbed DRACOs (Double-stranded RNA Activated Caspase Oligomerizers), from living cells’ own defense systems. When viruses infect a cell, they take over its cellular machinery for their own purpose — that is, creating more copies of the virus. During this process, the viruses create long strings of double-stranded RNA (dsRNA), which is not found in human or other animal cells.

As part of their natural defenses against viral infection, human cells have proteins that latch onto dsRNA, setting off a cascade of reactions that prevents the virus from replicating itself. However, many viruses can outsmart that system by blocking one of the steps further down the cascade.

Rider had the idea to combine a dsRNA-binding protein with another protein that induces cells to undergo apoptosis (programmed cell suicide) — launched, for example, when a cell determines it is en route to becoming cancerous. Therefore, when one end of the DRACO binds to dsRNA, it signals the other end of the DRACO to initiate cell suicide.

Combining those two elements is a “great idea” and a very novel approach, says Karla Kirkegaard, professor of microbiology and immunology at Stanford University. “Viruses are pretty good at developing resistance to things we try against them, but in this case, it’s hard to think of a simple path pathway to drug resistance,” she says.

Each DRACO also includes a “delivery tag,” taken from naturally occurring proteins, that allows it to cross cell membranes and enter any human or animal cell. However, if no dsRNA is present, DRACO leaves the cell unharmed.

Very cool stuff and potentially hugely beneficial. Just a reminder: this works against viruses – not bacteria (just as antibiotics do not work against viruses).

image showing the results of cultures treated with DRACO v. those not treated

Related: Science Explained: RNA Interference8 Percent of the Human Genome is Old Virus GenesVirus Engineered To Kill Deadly Brain Tumors
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Swarmanoid: Cooperative Robot Networks

Very cool cooperation between robots. It seems more and more research is going on in cooperative robotics. It would seem this would let us have specialized robots for various tasks instead of having to have robots that can do everything (which is very complex and difficult). Plus cooperating robots are just cool. See the Swarmanoid project web site and the overarching Swarmbot site. I look forward to what these scientists and engineers can create for us.

Related: Robots Working Together to Share Talents (2006)Autonomous Helicopters Teach Themselves to FlyUnderwater Robots Collaborate

Quantum Information Theory Postulated As Source of Emergent Theory of Gravity

I love the advances we have made using our understanding of science and engineering, like the internet, air conditioning and antibiotics. I also love the discussion of research where we really have only educated guesses about what the scientific inquiry process is telling us about the way things are. This research from the University of York is very interesting.

Escaping gravity’s clutches: the black hole breakout

Professor Braunstein says: “Our results didn’t need the details of a black hole’s curved space geometry. That lends support to recent proposals that space, time and even gravity itself may be emergent properties within a deeper theory. Our work subtly changes those proposals, by identifying quantum information theory as the likely candidate for the source of an emergent theory of gravity.”

Dr Patra adds: “We cannot claim to have proven that escape from a black hole is truly possible, but that is the most straight-forward interpretation of our results. Indeed, our results suggest that quantum information theory will play a key role in a future theory combining quantum mechanics and gravity.”

It is too bad the University of York supports closed science and allows work to be withheld from the public to support outdated publishers business models. Luckily scientists often support open science and publish material openly – I have provided a link for those interested in science instead of the link the University of York gives to a publishers closed system.

Black Hole Evaporation Rates without Spacetime

Verlinde recently suggested that gravity, inertia, and even spacetime may be emergent properties of an underlying thermodynamic theory. This vision was motivated in part by Jacobson’s 1995 surprise result that the Einstein equations of gravity follow from the thermodynamic properties of event horizons. Taking a first tentative step in such a program, we derive the evaporation rate (or radiation spectrum) from black hole event horizons in a spacetime-free manner. Our result relies on a Hilbert space description of black hole evaporation, symmetries therein which follow from the inherent high dimensionality of black holes, global conservation of the no-hair quantities, and the existence of Penrose processes. Our analysis is not wedded to standard general relativity and so should apply to extended gravity theories where we find that the black hole area must be replaced by some other property in any generalized area theorem.

Related: Gravity and the Scientific MethodGravity May Emerge from Quantum InformationDoes Time ExistWebcast of Astronaut Testing Gravity on the Moonsupport open science

Evolution of Altruism in Robots

The webcast explores robots evolving cooperative behavior. A Quantitative Test of Hamilton’s Rule for the Evolution of Altruism (open access paper)

One of the enduring puzzles in biology and the social sciences is the origin and persistence of altruism, whereby a behavior benefiting another individual incurs a direct cost for the individual performing the altruistic action. This apparent paradox was resolved by Hamilton’s theory, known as kin selection, which states that individuals can transmit copies of their own genes not only directly through their own reproduction but also indirectly by favoring the reproduction of kin, such as siblings or cousins. While many studies have provided qualitative support for kin selection theory, quantitative tests have not yet been possible due to the difficulty of quantifying the costs and benefits of helping acts. In this study, we conduct simulations with the help of a simulated system of foraging robots to manipulate the costs and benefits of altruism and determine the conditions under which altruism evolves.

By conducting experimental evolution over hundreds of generations of selection in populations with different costs and benefits of altruistic behavior, we show that kin selection theory always accurately predicts the minimum relatedness necessary for altruism to evolve. This high accuracy is remarkable given the presence of pleiotropic and epistatic effects, as well as mutations with strong effects on behavior and fitness. In addition to providing a quantitative test of kin selection theory in a system with a complex mapping between genotype and phenotype, this study reveals that a fundamental principle of natural selection also applies to synthetic organisms when these have heritable properties.

Related: Robots That Start as Babies Master Walking Faster Than Those That Start as AdultsFriday Fun: Robocup 2010, Robot FootballToyota Develops Thought-controlled Wheelchair
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