Healthy Living Greatly Reduces Likelihood of Dying from Cancer

Posted on May 28, 2016  Comments (0)

Lifestyle choices can greatly reduce the incidence and death rates from cancer. 4 factors can reduce the incidence of cancer by up to 40% and death rate by 50%: don’t smoke, don’t drink alcohol in excess, maintain a BMI between 18.5 and 27.5, and exercising at a moderate intensity for at least 150 minutes or at a vigorous intensity for at least 75 minutes every week.

Preventable Incidence and Mortality of Carcinoma Associated With Lifestyle Factors Among White Adults in the United States

A substantial cancer burden may be prevented through lifestyle modification. Primary prevention should remain a priority for cancer control.

Cancer is the second leading cause of death in the United States, with 1.6 million new cancer cases and 0.6 million cancer deaths projected to occur in 2016.1 The cancer mortality rate, age-standardized to the 2000 US standard population, decreased from 199 to 163 per 100 000 between 1969 and 2013.2 However, this decline (17.9%) has been modest compared with the dramatic decrease in heart disease mortality (67.5%) during the same period, highlighting the need for further efforts in cancer prevention and treatment.

The study reviewed previous studies and the makeup of the previous studies and available statistics. As they state in the paper: “Because our cohorts’ participants were predominantly whites, to avoid any influence of different racial distributions on the comparison with the general population, we only included whites in the analysis.” They also excluded about 10% of cancers that are believed to have strong environmental factors.

Table Showing a Comparison of Lifestyle Factors in the Low- and High-Risk Groups

In the 2 cohort studies of US white individuals, we found that overall, 20% to 40% of carcinoma cases and about half of carcinoma deaths can be potentially prevented through lifestyle modification. Not surprisingly, these figures increased to 40% to 70% when assessed with regard to the broader US population of whites, which has a much worse lifestyle pattern than our cohorts.

Notably, approximately 80% to 90% of lung cancer deaths could be avoided if Americans adopted the lifestyle of the low-risk group, mainly by quitting smoking. For other cancers, from 10% to 70% of deaths could be prevented. These results provide strong support for the importance of environmental factors in cancer risk and reinforce the enormous potential of primary prevention for cancer control.

Related: A Healthy Lifestyle is More About Health Care than the Sickness Management That We Call Health Care IsBetter Health Through: Exercise, Not Smoking, Low Weight, Healthy Diet and Low Alcohol Intake (2013)Exercise Is Really Really Good for YouPhysical Activity for Adults: Inactivity Leads to 5.3 Million Early Deaths a Year (2012)

International Science Research Scholar Grants

Posted on May 24, 2016  Comments (0)

The Howard Hughes Medical Institute (HHMI), Bill & Melinda Gates Foundation, Wellcome Trust, and Calouste Gulbenkian Foundation have announced the International Research Scholars Program which aims to support up to 50 outstanding early career scientists worldwide. The program’s aim is to help develop scientific talent worldwide.

The new international competition is seeking top early career researchers from a wide variety of biomedical research fields. Applicants must have started their first independent research position on or after April 1, 2009. Awardees will be invited to participate in research meetings with scientists supported by the funders. These meetings facilitate the exchange of ideas, stimulate new research, and provide an opportunity for collaborative endeavors within the international scientific community.

  • Awardees will receive a total of $650,000 over five years.
  • Applications are due June 30, 2016.
  • Awardees will be notified in April 2017.

HHMI and its partners have committed a total of $37.4 million for the International Research Scholars Program and will award each scientist who is selected a total of $650,000 over five years. The competition is open to scientists who have trained in the U.S. or United Kingdom for at least one year. Additionally, eligible scientists must have run their own labs for less than seven years, and work in one of the eligible countries.

Nieng Yan

Although Nieng Yan had several grants when she started her lab at Tsinghua University in 2007, she barely had enough money to pay her eight lab members. “In China, there is a limit on the percentage of a grant that you can use to pay people — your graduate students, your postdocs, your technicians, your assistants — to a decent level,” she explains. After struggling to balance her budget for several years, Yan’s scientific achievements and potential landed her an international grant from HHMI in 2012. “The amount of money provided by Hughes is relatively small compared to other programs, but it has the advantage that you can freely decide what to do with it,” says Yan. In fact, HHMI’s science officers encouraged Yan to use her five-year International Early Career Award (IECS) to cover the cost of paying her lab team, explaining that the money could be used in any way that assisted her research. Today, Yan has 15 people working in her lab helping to elucidate the structures of proteins that move molecules in and out of cells. The protein channels and transporters they study are mutated in a number of diseases — including diabetes and cancer — and understanding how they work could help in the development of drugs that block their ill effects. For example, the team recently solved the structure of GLUT1 – a glucose transporter that is often overexpressed in malignant tumor cells. Their data may provide clues for how to inhibit the transporter and perhaps even reveal a way to use it to deliver chemotherapeutic drugs. Photo Credit: Kevin Wolf (AP)

Countries that are not eligible for this competition include the G7 countries (Canada, France, Germany, Italy, Japan, United Kingdom and United States), as well as countries identified by the U.S. Department of Treasury, Office of Foreign Assets Control (OFAC) as being subject to comprehensive country or territory-wide sanctions or where current OFAC regulations prohibit U.S. persons or entities from engaging in the funding arrangements contemplated by this grant program. For this program, such sanctioned countries or territories currently include Iran, North Korea, Sudan, Syria, and the Crimea region of Ukraine.

Related: Directory of Science and Engineering Scholarships and FellowshipsFunding Sources for Independent Postdoctoral Research Projects in BiologyScientific Research Spending Cuts in the USA and Increases Overseas are Tempting Scientists to Leave the USA (2013)HHMI Expands Support of Postdoctoral Scientists (2009)Science, Engineering and Math Fellowships

USA Health Care Crisis: Opioid Abuse

Posted on May 17, 2016  Comments (0)

In 2014 about 34,000 deaths in the USA died in car crashes and about the same number of deaths resulted from gun violence, but more than 47,000 people died from drug overdoses.

Opioid abuse has greatly increased these deaths in the last decade. Chronic pain is a real problem we need to manage. But the current practices are leading to troubling results as are our methods for dealing with drug abuse (including illegal drugs such as heroin). Abusing prescription drugs such as addictive opioids and illegal drugs such as heroin are both leading to an increasing number of deaths in the last decade.

Worldwide somewhere between 26 and 34 million people are abusing opioids. More than 2 million of them are Americans abusing prescription opioids.

Heroin is an example of a non-prescription opioid.

Admissions for the treatment of abuses of prescription opioids constituted about 1% of [USA emergency room] admissions in 1997, and they made up 5% of admissions a decade later.

Related: President Obama Proposes $1.1 Billion in New Funding to Address the Prescription Opioid Abuse and Heroin Use Epidemic200,000 People Die Every Year in Europe from Adverse Drug Effects – How Can We Improve?The War on Drugs has been a Huge Failure with Massive Unintended Consequences (we need to use health care strategies to manage the problem not war strategies)Over-reliance on Prescription Drugs to Aid Children’s Sleep? (2007)

Bitbeam: Open Source Hardware Prototyping Platform

Posted on April 19, 2016  Comments (0)

Bitbeam is an open source construction toy/hardware prototyping platform. A collection of LEGO Technic compatible parts (beams) which can be combined to construct whatever contraption the user has thought up.

The Bitbeam project aims to define a set of parts which the users themselves can produce using increasingly available technologies for local fabrication like 3D printers, laser cutters and CNC mills.

view of various piece of 3d printed items

Tapster is a robot that automates mobile application checking on a smartphone. It is built using bitbeam.

The latest post on the Bitbeam web site is from 2013 but it seems it is still an active project (it would be nice if they update the site).

Please add a comment if you now of updated information or of similar open source projects.

Related: Open Source Ecology: Using Open Engineering to Create Economic BenefitArduino Introduction Video Tutorial3D Printing at Home: Today, Challenges and OpportunitiesIntroduction Video on 3D PrintingLego Mindstorms Robots Solving: Sudoku and Rubik’s Cube (2009)

Sustainable Ocean Farming

Posted on April 3, 2016  Comments (2)

Farming the Sea: why eating kelp is good for you and good for the environment

There are serious problems with our ability to grow healthy food for the number of people we have today (and will have in the future). Innovations have allowed us to feed ourselves. But the damage done to topsoil and other damage including pollution of our rivers is huge. Overfishing and factory farms are keeping us going today but are doing immense damage and are not sustainable.

Seed companies abusing the corrupt government patent systems creates even more damage. We need better solutions. We have many people doing great things but we need to do much more. Ocean farming is one of many areas we should expand. And we should greatly reduce the use of factory farms, antibiotics for livestock, overfishing and the overuse of pesticides.

How an Army of Ocean Farmers are Starting an Economic Revolution

So we all went on a search for sustainability. I ended up in Northern Canada on an aquaculture farm. At that point aquaculture was supposed to be the great solution to overfishing, but when I got there I found more of the same, only using new technologies to pollute local waterways with pesticides and pumping fish full of antibiotics.

I never thought climate change had anything to do with my life. But it does. From my vantage point, climate change is not an environmental issue at all — it’s an economic issue.

As ocean farmers, we reject aquaculture’s obsession with monoculture, an obsession similar to that of modern land farming. Our goal is diversity. It’s a sea-basket approach:We grow two types of seaweeds, four kinds of shellfish, and we harvest salt. But with over 10,000 edible plants in the ocean, we’ve barely scratched the surface.

Instead of repeating history we’re building infrastructure from seed-to-harvest-to-market. We’re starting nonprofit hatcheries so that our farmers can access low-cost seed. We’re creating ocean seed banks so that the Monsantos of the world can’t privatize the source of our food and livelihoods.

Related: SelFISHingThe State of the Oceans (2011)Rethinking the Food Production System (2008)

Medicinal Plants

Posted on March 24, 2016  Comments (0)

Another great webcast from SciShow. In this webcast Hank Green discusses how we have used plants to treat us and improve our health.

In the webcast, Hank also does a good job touching a bit on the scientific inquiry process (which is something I find interesting and I think is very important for people living in society today to understand).

Related: Youyou Tu, The First Chinese Woman to Win a Nobel PrizeRubber TreesPhotosynthesis: Science Explained

Gut Bacteria Explored as Medical Treatment – even for Cancer

Posted on March 14, 2016  Comments (0)

The interaction between gut bacteria and human health continues to be a fertile area of medical research. It appears to be in the very early days of such research. Of course, as I have said before, headline making news often doesn’t result in medical breakthrough, and even when it does a decade isn’t a long wait for it to happen.

How Gut Bacteria Are Shaking Up Cancer Research

In November, University of Chicago researchers wrote that giving mice Bifidobacterium, which normally resides in the gastrointestinal tract, was as effective as an immunotherapy in controlling the growth of skin cancer. Combining the two practically eliminated tumor growth. In the second study, scientists in France found that some bacterial species activated a response to immunotherapy, which didn’t occur without the microbes.

The complex interactions involved in human health is another area that has huge room for research going forward.

Related: Some Bacteria Might Fight Cancer (2008)Cancer Vaccines (2011)Using Diatom Algae to Deliver Chemotherapy Drugs Directly to Cancer Cells (2015)Webcast of a T-cell Killing a Cancerous Cell (2012)

Webcasts on the Human Microbiome

Posted on February 27, 2016  Comments (2)

The human microbiome is a very interesting aspect of our health and biology.

The 99% figure they quote is mainly silly. It might be technically accurate, but it is much more misleading than accurate (if it is accurate). We have more non-human cells than human but those cells are much smaller and we are overwhelmingly made up of human cells by weight (95+%).

The complexity of healthy bodies is far from understood. It is interesting to watch our understanding of the balancing act going on inside of us. Many foreign “invaders” are critical to our health.

Related: People are Superorganisms With Microbiomes of Thousands of SpeciesPeople Have More Bacterial Cells than Human CellsFighting Superbugs with Superhero BugsWe Have Thousands of Viruses In Us All the Time

Read more

Google Cardboard 3d Viewer Helped Surgeons Save Baby’s Life

Posted on February 14, 2016  Comments (4)

$20 cardboard toy saves baby’s life

Doctors at Nicklaus Children’s Hospital in Miami used the device to map out an operation they say they couldn’t have envisioned otherwise.

“It was mind-blowing,” says Cassidy Lexcen, the baby’s mother. “To see this little cardboard box and a phone, and to think this is what saved our daughter’s life.”

Google Cardboard is a virtual reality and augmented reality platform developed by Google for use with a head mount for smart phone. Just get a simple cardboard holder you wear like goggles and an app for Android or iOS and you can view cool 3d virtual realities.

Related: Night Vision Contact LensesiPhone Addition as Alternative to Expensive Ophthalmology EquipmentVery Cool Wearable Computing Gadget from MITCool Mechanical Simulation System

Cleaning Up the Plastic Pollution in Our Oceans

Posted on January 30, 2016  Comments (0)

This is an interesting talk on an important topic: cleaning up plastic in the ocean. ,a student from the Netherlands, looked to find a solution to a problem others said couldn’t be solved.

This is exactly the type of wonderful activity that inspired people can accomplish using science and engineering. He collected an understanding of the 50 issues that supposedly makes a solution impossible.

After getting funding (sparked by an explosion of viral social media) he worked on exploring the “insolvable” problems (having withdrawn from school to work on this problem). It is wonderful to see what we can do when inspired people use science and engineering to make the world a better place.

From their website, The Ocean Cleanup

In the feasibility report, we estimated that a 100-kilometer array operating in the North Pacific gyre for 10 years could remove 42% of the plastics in the area, or an estimated 70 million kilograms.

The plastic will be stored in an internal buffer within the platform at the tip of the V-shaped array. The plastic in the buffer will regularly be emptied onto a vessel that comes to collect it for transport to land. This will occur approximately once every six weeks, depending on the size of the vessel.

Besides monetary support, your relevant knowledge and skills may be a very welcome addition to The Ocean Cleanup. Our work requires not only scientific and technical expertise, but also assistance with legal, commercial and policy matters. If you would like to get actively involved in our work, If you would like to get actively involved in our work, please visit the careers page.

They aim to put a full scale pilot project in place in 3 to 4 years.

Related: Albatross Chicks Fed Plastic Ocean Pollution by ParentsAltered Oceans: the Crisis at Sea (2006)Using Robots to Collect Data on our OceansDead Zones in the Ocean

Ancient Chinese Natural Gas Drilling Using Bamboo

Posted on January 23, 2016  Comments (0)

This very interesting article is a great read about the history of Chinese bamboo drilling by Oliver Kuhn.

The first recorded salt well in China was dug in Sichuan Province, around 2,250 years ago. This was the first time water well technology was applied successfully to the exploitation of salt, and marked the beginning of Sichuan’s salt drilling industry. From that point on, wells in Sichuan have penetrated the earth to tap into brine aquifers, essentially ground water with a salinity of over 50g/l. The water is then evaporated using a heat source, leaving the salt behind.

At some point around 2,000 years ago the leap from hand and shovel dug wells to percussively drilled ones was made. By the beginning of the 3rd century AD, wells were being drilled up to 140m deep. The drilling technique used can still be seen in China today, when rural farmers drill water wells. The drill bit is made of iron, the pipe bamboo. The rig is constructed from bamboo; one or more men stands on a wooden plank lever, much like a seesaw, and this lifts up the drill stem a metre or so. The pipe is allowed to drop, and the drill bit crashes down into the rock, pulverizing it. Inch by inch, month by month, the drilling slowly progresses.

A major breakthrough was achieved around 1050 AD, allowing deeper wells, when solid bamboo pipe was replaced by thin, light, flexible bamboo “cable”. This dramatically lowered the weight that needed to be lifted from the surface, a weight that increased with the depth being drilled. By the 1700s Sichuan wells were typically in the range of 300 – 400m deep

One bamboo pipe line would take away the brine, and others the gas. The 2,000 year plus Sichuan salt industry has drilled approximately 130,000 brine and gas wells, and 10% of those were in the immediate Zigong area. Zigong has a cumulative gas production over this period of over 30 billion cubic metres. The area continues to be a major salt producer, and many of the historical wells are still in production.

drawing of Chinese drilling scene

An ancient sketch originally from “The Annals of Salt Law of Sichuan Province”. A “Kang Pen” drum is seen in the centre foreground, with gas pipes directly feeding the salt stoves on the right. At the top, brine from a remote well is being carried in buckets by men, who feed it into a bamboo pipeline that runs down to the stoves. One of the carriers is being paid at top left, and it appears that a blow out is depicted on a new well being drilled.
(from Zhong & Huang)

As recently as the 1950s there was still over 95km of bamboo pipeline in operation in the Zigong area.

Related: Research on Ancient Roman Concrete Will Allow the Creation of More Durable and Environmentally Friendly ConcreteWhy did China’s Scientific Innovation Stop?Hyperloop – Fast Transportation Using a Better Engineering Solution Than We Do Now

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