McMaster University researchers have developed a vaccine which successfully treats people with an allergy to cats. Traditionally, frequent allergy shots have been considered the most effective way to bring relief — other than getting rid of the family pet — for the 8 to 10% of the population allergic to cats.
Both options, may now be avoided thanks to the work of immunologist Mark Larché, professor at the Michael G. DeGroote School of Medicine and Canada Research Chair in Allergy & Immune Tolerance.
Building on research he’s conducted for the past 10 years in Canada and Britain, Larché and his research team have developed a vaccine which is effective and safe with almost no side effects. The research is published in a the January 2011 issue of the Journal of Allergy & Clinical Immunology, a leading journal in the allergy field.
The researchers took one protein (molecule) that cats secrete on their fur which causes the majority of allergic problems. Using blood samples from 100 patient volunteers allergic to cats, they deconstructed the molecule and identified short regions within the protein which activate T-cells (helper cells that fight infection) in the immune system.
Using the amino acid code for the whole protein, researchers made synthetic versions of these regions. For the cat allergy vaccine, they found seven peptides (strings of amino acids). “And those synthetic peptides are what we mix together to make the vaccine,” said Larché. “We picked the peptides that would work in as much of the population as possible.”
Known as “peptide immunotherapy,” a low dose of the vaccine is given into the skin. Initially, four to eight doses a year may be required, but the side effects of the traditional allergy shots do not arise, Larché said. The optimal dose will be determined in phase three clinical trials which are getting underway with a much larger group of cat allergy sufferers.
The development of a vaccine to treat people allergic to cats is the first in a line of vaccines developed with Adiga Life Sciences, a company established at McMaster in 2008. It is a joint venture between McMaster University Circassia Ltd., a UK-based biotech company.
Adiga and McMaster are now collaborating on research into the use of peptide immunotherapy for house dust mite, ragweed, grass, birch tree and moulds
Related: MIT Engineers Design New Type of Nanoparticle for Vacines – 10 Questions to Ask Your Vet About Cat Medications – Vaccine For Strep Infections
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Appropriate Technology: Self Adjusting Glasses
Posted on December 25, 2008 Comments (3)
Self Adjusting Glasses for 1 billion of the world’s poorest see better
More than two decades after posing that question, Josh Silver [a physics professor at Oxford] now feels he has the answer. The British inventor has embarked on a quest that is breathtakingly ambitious, but which he insists is achievable – to offer glasses to a billion of the world’s poorest people by 2020.
Some 30,000 pairs of his spectacles have already been distributed in 15 countries, but to Silver that is very small beer. Within the next year the now-retired professor and his team plan to launch a trial in India which will, they hope, distribute 1 million pairs of glasses. The target, within a few years, is 100 million pairs annually.
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Silver has devised a pair of glasses which rely on the principle that the fatter a lens the more powerful it becomes. Inside the device’s tough plastic lenses are two clear circular sacs filled with fluid, each of which is connected to a small syringe attached to either arm of the spectacles.
The wearer adjusts a dial on the syringe to add or reduce amount of fluid in the membrane, thus changing the power of the lens. When the wearer is happy with the strength of each lens the membrane is sealed by twisting a small screw, and the syringes removed. The principle is so simple, the team has discovered, that with very little guidance people are perfectly capable of creating glasses to their own prescription.
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Oxford University, at his instigation, has agreed to host a Centre for Vision in the Developing World, which is about to begin working on a World Bank-funded project with scientists from the US, China, Hong Kong and South Africa. “Things are never simple. But I will solve this problem if I can. And I won’t really let people stand in my way.”
Cool. A couple points I would like to make:
1) this professor is making a much bigger difference in the “real world” than most people ever will. The idea that professors are all lost in insignificant “ivory towers” is a very inaccurate view of what really happens.
2) Spending money on this kind of thing seems much more important for the human race than spending trillions to bail out poor moves by bankers, financiers… It sure seems odd that we can’t find a few billion to help out people across the globe that are without basic necessities yet we can find trillions to bail out the actions of few thousand bad actors.
Related: Adaptive Eyecare – Bringing Eye Care to Thousands in India – River Blindness Worm Develops Resistance to Drugs – Strawjet: Invention of the Year (2006) – Fixing the World on $2 a Day – Appropriate Technology
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