Key Indicator for Malignant Melanoma Found

Posted on September 20, 2012  Comments (2)

Skin cancer detection breakthrough

The researchers found that certain biochemical elements in the DNA of normal pigment-producing skin cells and benign mole cells are absent in melanoma cells. Loss of these methyl groups — known as 5-hmC — in skin cells serves as a key indicator for malignant melanoma. Loss corresponded to more-advanced stages of melanoma as well as clinical outcome.

Strikingly, researchers were able to reverse melanoma growth in preclinical studies. When the researchers introduced enzymes responsible for 5-hmC formation to melanoma cells lacking the biochemical element, they saw that the cells stopped growing.

“It is difficult to repair the mutations in the actual DNA sequence that are believed to cause cancer,” said Christine Lian, a physician-scientist in the Department of Pathology at BWH and one of the lead authors. “So having discovered that we can reverse tumor cell growth by potentially repairing a biochemical defect that exists — not within the sequence but just outside of it on the DNA structure — provides a promising new melanoma treatment approach for the medical community to explore.”

Because cancer is traditionally regarded as a genetic disease involving permanent defects that directly affect the DNA sequence, this new finding of a potentially reversible abnormality that surrounds the DNA (thus termed “epigenetic”) is a hot topic in cancer research, according to the researchers.

In the United States, melanoma is the fifth most common type of new cancer diagnosis in men and the seventh most common type in women. The National Cancer Institute estimates that in 2012 there will be 76,250 new cases and 9,180 deaths in the United States owing to melanoma.

Thankfully scientists keep making great progress in understanding and finding potential clues to treating cancer. And big gains have been made in treating some cancers over the last few decades. But the research successes remain difficult to turn into effective solutions in treating patients.

I am thankful we have so many scientists doing good work in this difficult and important area (cancer).

Related: Webcast of a T-cell Killing a Cancerous CellNanoparticles With Scorpion Venom Slow Cancer SpreadDNA Passed to Descendants Changed by Your LifeResearchers Find Switch That Allows Cancer Cells to Spread

2 Responses to “Key Indicator for Malignant Melanoma Found”

  1. Jack
    September 21st, 2012 @ 1:00 am

    Cancer which until recently was incurable is becoming less of a threat as our scientists seem to work really hard on finding a cure. i am not saying that Cancer is totally curable but yes with the amount of good work we have at least reached a stage where we can treat it rather than leaving it on its own. Medical Science no doubt is making a lot of discoveries and that is why is able to come up with so many new things. This blog turns to be very helpful in letting the common man know about these discoveries.

  2. Erica Williams
    September 25th, 2012 @ 2:50 am

    Certainly scientists are doing their best to find some permanent solution to this life threatning disease, actually cancer is curable but if caught at initial stage but the problem is; it never let the victim know and when reaches at last or upper stage its too late by then. But thanks to the scientists for their continuous hardworking and to this blog for letting everyone know about latest developments/descoveries.

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