Why Most Published Research Findings Are False

Posted on September 3, 2005  Comments (2)

Why Most Published Research Findings Are False by John P. A. Ioannidis

A finding from a well-conducted, adequately powered randomized controlled trial starting with a 50% pre-study chance that the intervention is effective is eventually true about 85% of the time. A fairly similar performance is expected of a confirmatory meta-analysis of good-quality randomized trials: potential bias probably increases, but power and pre-test chances are higher compared to a single randomized trial.

2 Responses to “Why Most Published Research Findings Are False”

  1. Curious Cat Science and Engineering Blog » I Support the Public Library of Science
    September 2nd, 2007 @ 3:06 pm

    I am a fan of the Public Library of Science, as I have mentioned previous. Yesterday I donated some money to support their great efforts…

  2. Statistical Errors in Medical Studies » Curious Cat Science and Engineering Blog
    February 25th, 2014 @ 10:10 am

    […] have posted about reasons for systemic reasons for medical studies presenting misleading results (Why Most Published Research Findings Are False, How to Deal with False Research Findings, Medical Study Integrity (or Lack Thereof), Surprising […]

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