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Regeneron High School Science Talent Search 2019

Posted on April 19, 2019  Comments (1)

$3.1 million in prizes was awarded through the Regeneron Science Talent Search 2019, including $2,000 to each of the top 300 scholars and their schools. The top award was for $250,000. If you want to watch the video without knowing the winner, watch it before reading the rest of this post.

Every year the accomplishments of high school students provide amazing hope for the future. I am glad for the organizations that highlight the efforts of these students and provide awards for a few of the most amazing accomplishments. The top 40 students all get at least $25,000 (with the top 10 getting more).

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Youyou Tu: The First Chinese Woman to Win a Nobel Prize

Posted on October 17, 2015  Comments (2)

The Nobel Prize in Physiology or Medicine 2015 was divided, one half jointly to William C. Campbell (born Ireland, now USA) and Satoshi ÅŒmura (Japan) “for their discoveries concerning a novel therapy against infections caused by roundworm parasites” and the other half to Youyou Tu (China) “for her discoveries concerning a novel therapy against Malaria”.

Youyou Tu is the first Chinese woman to win a Nobel Prize.

Diseases caused by parasites have plagued humankind for millennia and constitute a major global health problem. In particular, parasitic diseases affect the world’s poorest populations and represent a huge barrier to improving human health and wellbeing. This year’s Nobel Laureates have developed therapies that have revolutionized the treatment of some of the most devastating parasitic diseases.

William C. Campbell and Satoshi ÅŒmura discovered a new drug, Avermectin, the derivatives of which have radically lowered the incidence of River Blindness and Lymphatic Filariasis, as well as showing efficacy against an expanding number of other parasitic diseases. Youyou Tu discovered Artemisinin, a drug that has significantly reduced the mortality rates for patients suffering from Malaria.

These two discoveries have provided humankind with powerful new means to combat these debilitating diseases that affect hundreds of millions of people annually. The consequences in terms of improved human health and reduced suffering are immeasurable.

image of Artemisinin

via Noble Prize website

Malaria was traditionally treated by chloroquine or quinine, but with declining success. By the late 1960s, efforts to eradicate Malaria had failed and the disease was on the rise. At that time, Youyou Tu in China turned to traditional herbal medicine to tackle the challenge of developing novel Malaria therapies. From a large-scale screen of herbal remedies in Malaria-infected animals, an extract from the plant Artemisia annua emerged as an interesting candidate.

However, the results were inconsistent, so Tu revisited the ancient literature and discovered clues that guided her in her quest to successfully extract the active component from Artemisia annua. Tu was the first to show that this component, later called Artemisinin, was highly effective against the Malaria parasite, both in infected animals and in humans. Artemisinin represents a new class of antimalarial agents that rapidly kill the Malaria parasites at an early stage of their development, which explains its unprecedented potency in the treatment of severe Malaria.

Youyou Tu was born in 1930 in China and is a Chinese citizen. She graduated from the Pharmacy Department at Beijing Medical University in 1955. From 1965-1978 she was Assistant Professor at the China Academy of Traditional Chinese Medicine, from 1979-1984 Associate Professor and from 1985 Professor at the same Institute. From 2000, Tu has been Chief Professor at the China Academy of Traditional Chinese Medicine. She doesn’t have a doctorate, very rare for a Nobel Prize winner in the sciences.

Read the full press release

Related: Nobel Prize in Physiology or Medicine 2012 for Reprogramming Cells to be Pluripotent – Nobel Prize in Physiology or Medicine 2008 – Parasites in the Gut Help Develop a Healthy Immune System – 2011 Nobel Prize in Physiology or Medicine – Video showing malaria breaking into cell

Intel International Science and Engineering Fair 2015

Posted on May 19, 2015  Comments (2)

Raymond Wang, 17, of Canada was awarded first place for engineering a new air inlet system for airplane cabins to improve air quality and curb disease transmission at this year’s Intel International Science and Engineering Fair.

Wang’s system improves the availability of fresh air in the cabin by more than 190% while reducing pathogen inhalation concentrations by up to 55 times compared to conventional designs, and can be easily and economically incorporated in existing airplanes. Wang received the Gordon E. Moore Award of US$75,000. The system uses vents to create a “bubble” around passengers that deflects incoming air.

Nicole Ticea, 16, of Canada received one of two Intel Foundation Young Scientist Awards of US$50,000 for developing an inexpensive, easy-to-use testing device to combat the high rate of undiagnosed HIV infection in low-income communities. Her disposable, electricity-free device provides results in an hour and should cost less than US$5 to produce. Ticea has already founded her own company, which recently received a US$100,000 grant to continue developing her technology.

Karan Jerath, 18, of Friendswood, Texas, received the other Intel Foundation Young Scientist Award of US$50,000 for refining and testing a novel device that should allow an undersea oil well to rapidly and safely recover following a blowout. Jerath developed a better containment enclosure that separates the natural gas, oil and ocean water; accommodates different water depths, pipe sizes and fluid compositions; and can prevent the formation of potentially clogging methane hydrate.

This year’s Intel International Science and Engineering Fair featured approximately 1,700 young scientists selected from 422 affiliate fairs in more than 75 countries, regions and territories.

Related: Intel Science Talent Search 2012 Awardees – Great Projects From First Google Science Fair Finalists (2011) – 2008 Intel Science Talent Search – High School Student Creates: Test That is Much More Accurate and 26,000 Times Cheaper Than Existing Pancreatic Cancer Tests

2014 Ranking of the World’s Best Research Universities

Posted on February 28, 2015  Comments (1)

Shanghai’s Jiao Tong University produces an annual ranking of research universities. The methodology values publications and faculty awards (Nobel and Fields) which belies the focus on ranking research not for example the quality of education provided.

You could argue one measure does partially address teaching as the Nobel and Fields prizes to alumni are created to the institution (that is separate from a measure of faculty that receive those honors). I would agree it partially measure the education though it also measures the ability of that school to attract the absolute best candidates (whether they would have been just as successful going elsewhere is a fair question).

Results from the 2014 rankings of top 500 universities with the number of schools by country:

location Top 100 % of World
Population		 % of World GDP % of top 500
USA 52     4.5%   22.2%  29.2%
United Kingdom   8  0.9  3.5 7.6
Germany   4  1.1  5.0 7.8
Canada   4  0.5  2.4 4.2
France   4  0.9  3.8 4.2
Japan   3  1.8  7.8 3.8
Australia   4  0.3  1.5 3.8
China   0  19.2  11.7 8.8
Netherlands   4  0.2  1.3 2.6
Sweden   4  0.1  0.8 2.2
Switzerland   5  0.1  0.8 1.4
South Korea   0  .7  1.7 2.0
India   0  17.0  1.9 0.2

The top countries for top 100 and top 500 schools are listed above, but I skip over many after the top 7 or 8 to include a few countries I like to watch, see the ranking site for the full list. Country population and GDP data were taken from the World Development Indicators 2013, by the World Bank.

There is little change in top 100 since 2008, which I think is a good sign, it wouldn’t make much sense to have radical shifts quickly in this type of ranking. The USA lost 2 schools in the top 100, UK lost 3, Germany lost 2, Switzerland gained 2, Netherlands gain 2…

There is more change in the top 500 where changes are more sensible (there is probably not much separating schools ranked in the 300’s from those in the 500’s so variation and strong pushes (from countries like China) can have an impact. China gained 14 more schools in the top 500. China’s GDP also increased from 6.6% of global GDP to 11.7%.

University of Wisconsin – Madison is 24th, it was 17th in 2008 My father taught there while I grew up.
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Leslie Lamport Receives 2013 ACM Turing Award

Posted on November 22, 2014  Comments (1)

Leslie Lamport, a Principal Researcher at Microsoft Research, has been named as the recipient of the 2013 ACM A.M. Turing Award for imposing clear, well-defined coherence on the seemingly chaotic behavior of distributed computing systems, in which several autonomous computers communicate with each other by passing messages. He devised important algorithms and developed formal modeling and verification protocols that improve the quality of real distributed systems. These contributions have resulted in improved correctness, performance, and reliability of computer systems.

ACM (Association for Computing Machinery) announced that the funding level for the ACM Turing Award is now $1,000,000 (to be provided by Google). The new amount is four times its previous level. It seems to me the 14th of November 2014 is a bit late to announce the 2013 award winner, but for an extra $750,000 I would gladly wait a year (or a decade for that matter).

The new award level brings the computer science award to the level of Nobel Prizes and the Fields medal.

Leslie Lamport’s 1978 paper, “Time, Clocks, and the Ordering of Events in a Distributed System,” one of the most cited in the history of computer science.

Read more about the work of Leslie Lamport.

Related: Barbara Liskov wins Turing Award (2009) – Donald Knuth, Computer Scientist (2006) – Google 2006 Anita Borg Scholarship – 2008 Draper Prize for Engineering

RoboBoat 2014 – Student Designed Autonomous Boats

Posted on November 1, 2014  Comments (10)

The first video gives a recap of RoboBoat 2014. In 2014, Embry-Riddle Aeronautical University took 1st place. University of Florida was 2nd, followed by the Robotics Club at UCF and in 4th place the Georgia Institute of Technology.

The teams must design and build an autonomous boat to compete in challenges. During the competition, student teams race their autonomous surface vehicles through an aquatic obstacle course. This includes littoral area navigation, channel following, and autonomous docking. The competition provides an opportunity for students to develop skills in system engineering by accomplishing realistic missions with autonomous vehicles in the maritime environment.

A team participated from Diponegoro University, Semarang, Indonesia, which is next to me – though about as far from the finals as you can be on the globe.

Related: 9th International Autonomous Underwater Vehicle Competition – 20th Annual US First Robotics Competition – Botball 2009 Finals – Robo-One Grand Championship in Tokyo (2007) – Eco-Vehicle Student Competition

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Starting a Career in Science to Fight Cancer

Posted on June 14, 2014  Comments (1)

Keven Stonewall Preventing Colon Cancer from VNM USA on Vimeo.

Keven Stonewall is a student at the University of Wisconsin – Madison working to prevent colon cancer.

Related: I Always Wanted to be Some Sort of Scientist – High School Student Creates Test That is Much More Accurate and 26,000 Times Cheaper Than Existing Pancreatic Cancer Tests – Webcast of a T-cell Killing a Cancerous Cell

2012 Gordon Prize for Innovation in Engineering and Technology Education

Posted on January 10, 2013  Comments (0)

I have posted on the Olin College of Engineering several times. I really like what they are doing. Innovation in engineering education will pay high dividends, especially providing a focus on the nexus of engineering and entrepreneurship.

Olin College of Engineering’s three founding academic leaders, Richard Miller, David Kerns and Sherra Kerns, received one of engineering’s highest honors – the Bernard M. Gordon Prize. The $500,000 prize is awarded by the National Academy of Engineering to recognize innovation in engineering and technological education.

“This team of educational innovators has had a profound impact on society by improving the way we educate the next generation of engineers,” said NAE President Charles M. Vest. “Olin serves as an exemplar for the rest of the engineering world and a collaborative agent for change.”

Armed with one of the largest gifts in the history of higher education, the F. W. Olin Foundation recruited Richard Miller as Olin’s first employee in 1999. To help build the college from scratch, Miller recruited the founding academic leadership team including David Kerns and Sherra Kerns later that year. Together, they developed a vision for an engaging approach to teaching engineering and a new culture of learning that is intensely student centered.

To insure a fresh approach, Olin does not offer tenure, has no academic departments, offers only degrees in engineering, and provides large merit-based scholarships to all admitted students.

Perhaps the most important contribution the Gordon prize recipients made was the creation of a profoundly inclusive and collaborative process of experimentation and decision-making involving students in every aspect of the invention of the institution. This is illustrated by the decision in 2001 to recruit 30 young students to spend a year as “partners” in residence with the faculty in conducting many experiments together before establishing the first curriculum.

“As entrepreneurs, we learn to listen to our customers. Olin’s innovative approach was co-created by enterprising faculty, inspired students, and a dedicated staff, as well as collecting and integrating innovative approaches from more than 30 other institutions worldwide,” said David Kerns, current faculty at Olin and founding provost and chief academic officer of the college from 1999 to 2007.

With the extensive help of a collaborative team of faculty and students, and the guidance of the late Dr. Michael Moody, a novel academic program emerged. Some of the features include a nearly gender-balanced community, a strong focus on design process throughout all four years, extensive use of team projects, a requirement that students repeatedly “stand and deliver” to the entire community at the end of every semester, an experiential requirement in business and entrepreneurship, a capstone requirement outside of engineering, and a year-long corporate-sponsored design project in which corporations pay $50,000 per project.

Related: Illinois and Olin Aim to Transform Engineering Education – Webcast: Engineering Education in the 21st Century – Improving Engineering Education – How the Practice and Instruction of Engineering Must Change

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Solar Powered Water Jug to Purify Drinking Water

Posted on November 22, 2012  Comments (4)

Deepika Kurup, a 14-year-old New York student, won the Discovery Education 3M Young Scientist Challenge for her invention of a solar-powered water jug that changes dirty water into purified drinking water. She won the top prize of $25,000.

During “the 5 minutes of my presentation 15 children have died from lack of clean drinking water.”

I am thankful we have kids like this to create solutions for us that will make the world a better place. We rely on hundreds of thousands of such people to use science and engineering methods to benefit society.

Related: Strawjet: Invention of the Year – Cheap Drinking Water From Seawater – Water and Electricity for All – Thanksgiving, Appropriately (power of capitalism and people to provide long term increases in standards of living)

Nobel Prize in Physiology or Medicine 2012 for Reprogramming Cells to be Pluripotent

Posted on October 17, 2012  Comments (3)

The Nobel Prize in Physiology or Medicine 2012 was awarded “for the discovery that mature cells can be reprogrammed to become pluripotent.” The prize goes jointly to Sir John B. Gurdon, Gurdon Institute in Cambridge, UK and Shinya Yamanaka, Kyoto University (he is also a senior investigator at the Gladstone Institutes in the USA).

The Nobel Prize recognizes two scientists who discovered that mature, specialised cells can be reprogrammed to become immature cells capable of developing into all tissues of the body. Their findings have revolutionised our understanding of how cells and organisms develop.

John B. Gurdon discovered (in 1962) that the specialisation of cells is reversible. In a classic experiment, he replaced the immature cell nucleus in an egg cell of a frog with the nucleus from a mature intestinal cell. This modified egg cell developed into a normal tadpole. The DNA of the mature cell still had all the information needed to develop all cells in the frog.

Shinya Yamanaka discovered more than 40 years later, in 2006, how intact mature cells in mice could be reprogrammed to become immature stem cells. Surprisingly, by introducing only a few genes, he could reprogram mature cells to become pluripotent stem cells, i.e. immature cells that are able to develop into all types of cells in the body.

These groundbreaking discoveries have completely changed our view of the development and cellular specialisation. We now understand that the mature cell does not have to be confined forever to its specialised state. Textbooks have been rewritten and new research fields have been established. By reprogramming human cells, scientists have created new opportunities to study diseases and develop methods for diagnosis and therapy.

All of us developed from fertilized egg cells. During the first days after conception, the embryo consists of immature cells, each of which is capable of developing into all the cell types that form the adult organism. Such cells are called pluripotent stem cells. With further development of the embryo, these cells give rise to nerve cells, muscle cells, liver cells and all other cell types – each of them specialised to carry out a specific task in the adult body. This journey from immature to specialised cell was previously considered to be unidirectional. It was thought that the cell changes in such a way during maturation that it would no longer be possible for it to return to an immature, pluripotent stage.

Related: 2011 Nobel Prize in Physiology or Medicine – Nobel Prize in Physiology or Medicine 2008 – 2012 Nobel Prize in Chemistry to Robert Lefkowitz and Brian Kobilka

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2012 Nobel Prize in Chemistry to Robert Lefkowitz and Brian Kobilka

Posted on October 10, 2012  Comments (0)

The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry for 2012 to

  • Robert J. Lefkowitz, Howard Hughes Medical Institute and Duke University Medical Center, Durham, NC, USA
  • and Brian K. Kobilka, Stanford University School of Medicine, Stanford, CA, USA

for studies of G-protein–coupled receptors.

Your body is a fine-tuned system of interactions between billions of cells. Each cell has tiny receptors that enable it to sense its environment, so it can adapt to new situtations. Robert Lefkowitz and Brian Kobilka are awarded the 2012 Nobel Prize in Chemistry for groundbreaking discoveries that reveal the inner workings of an important family of such receptors: G-protein–coupled receptors.

For a long time, it remained a mystery how cells could sense their environment. Scientists knew that hormones such as adrenalin had powerful effects: increasing blood pressure and making the heart beat faster. They suspected that cell surfaces contained some kind of recipient for hormones. But what these receptors actually consisted of and how they worked remained obscured for most of the 20th Century.

Lefkowitz started to use radioactivity in 1968 in order to trace cells’ receptors. He attached an iodine isotope to various hormones, and thanks to the radiation, he managed to unveil several receptors, among those a receptor for adrenalin: β-adrenergic receptor. His team of researchers extracted the receptor from its hiding place in the cell wall and gained an initial understanding of how it works.

The team achieved its next big step during the 1980s. The newly recruited Kobilka accepted the challenge to isolate the gene that codes for the β-adrenergic receptor from the gigantic human genome. His creative approach allowed him to attain his goal. When the researchers analyzed the gene, they discovered that the receptor was similar to one in the eye that captures light. They realized that there is a whole family of receptors that look alike and function in the same manner.

Today this family is referred to as G-protein–coupled receptors. About a thousand genes code for such receptors, for example, for light, flavour, odour, adrenalin, histamine, dopamine and serotonin. About half of all medications achieve their effect through G-protein–coupled receptors.

The studies by Lefkowitz and Kobilka are crucial for understanding how G-protein–coupled receptors function. Furthermore, in 2011, Kobilka achieved another break-through; he and his research team captured an image of the β-adrenergic receptor at the exact moment that it is activated by a hormone and sends a signal into the cell. This image is a molecular masterpiece – the result of decades of research.

Related: More details on the research – 2011 Nobel Prize in Chemistry – 2009 Nobel Prize in Chemistry: the Structure and Function of the Ribosome – The Nobel Prize in Chemistry 2008