Curious Cat Science and Engineering Blog

Alzheimer’s and the Complex Scientific Inquiry Process

curiouscat — Wed, 30 Mar 2022 15:38:36 +0000

This webcast provides an interesting look at the complex scientific inquiry process: An Alzheimer’s Drug That Doesn’t Treat Alzheimer’s?

Medical research is complex. Once we figure out what is most critical and discover effective treatments often the explanations can then make it seem fairly simple. But that process is often decades of efforts that include years of frustration and confusion.

For long term medical impacts we often need to guess at important biomarker indications that may be closely related to health outcomes. But that process often isn’t as easy as it sounds.

Much Alzheimer’s research for the last few decades has focused on amyloid plaque reduction.

A new Alzheimer’s drug has been approved. But should you take it?

Aducanumab (brand name Aduhelm) is a monoclonal antibody engineered in a laboratory to stick to the amyloid molecule that forms plaques in the brains of people with Alzheimer’s. Most researchers believe that the plaques form first and damage brain cells, causing tau tangles to form inside them, killing the cells. Once aducanumab has stuck to the plaque, your body’s immune system will come in and remove the plaque, thinking it’s a foreign invader. The hope and expectation are that, once the plaques are removed, the brain cells will stop dying, and thinking, memory, function, and behavior will stop deteriorating.

I personally do not think the drug should have been approved. Continued research would be fine, but approving an extraordinarily expensive drug without strong evidence of significant positive health outcomes is very poor public policy.

mRNA Vaccine Targets Ticks to Allow Us to Avoid Diseases Ticks Carry

curiouscat — Thu, 30 Dec 2021 19:22:05 +0000

A lab-stage mRNA vaccine targeting ticks may offer protection against Lyme and other tick-borne diseases

A new laboratory-stage mRNA vaccine that teaches the immune system to recognize the saliva from tick bites could prevent these bugs from feeding on and transmitting tick-borne diseases to people
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What’s unique about the 19ISP mRNA vaccine is that instead of directly targeting the pathogen that causes the disease like traditional vaccines, 19ISP was able to stimulate resistance to the carrier of the disease, ticks, and prevent them from transmitting the pathogen in the first place. Our study also suggests that this form of tick-based vaccination – teaching the body to rapidly recognize and react to being bitten by a tick – may be sufficient to prevent infection.

mRNA vaccines have been in the news a great deal due to the covid19 mRNA vaccines. The potential for mRNA solutions is very promising. If this research can be confirmed and brought to market it could save us from Lyme disease and other diseases transmitted via ticks.

Toyota Mirai – Hydrogen Fuel Cell Electric Car

curiouscat — Thu, 12 Aug 2021 18:05:14 +0000

I am curious, even skeptical, about the potential for hydrogen fuel cell versus battery passenger cars. I do respect Toyota and so am wondering if they do indeed see something that most others are missing.

The current production Toyota Mirai has a range of 650 km.

I do think hydrogen fuel cells may provide a better option for larger vehicles (maybe even shipping), but I have done next to no research on this so I may be wrong.

It seem unlikely to me that hydrogen fuel cell passenger cars are going to make it but I would be happy to be wrong. Perhaps the advantages will overcome what seem to me to be challenges that are going to prevent them from being successful. I am confused about how committed to this strategy Toyota is (which makes me question my belief that hydrogen fuel cell passenger cars are not going to be successful).

Science Explained: Wind Powered Vehicle Traveling Faster Than the Wind

curiouscat — Sat, 03 Jul 2021 19:32:08 +0000

This is an interesting explanation of a the physics involved with vehicle propulsion. And it is a great video showing the scientific method at work.

They only touch on it a little bit but the need for creating 4 versions of the small treadmill device to illustrate the principles in action is a great example of how science inquiry and engineering work. There are often many failed attempts before an engineering solution to the issue involved can be properly created (video on Xyla Foxlin’s efforts: Building the Vehicle Physicists Called Impossible).

Enjoy the videos.

Veritasium is also offering 3 prizes to split the $10,000 for 1 minute videos that highlight science communicators with his Veritasium Science Communication Contest.

Benefits of a Mediterranean Diet May Include Reduced Risk of Cognitive Impairment As We Age

curiouscat — Sat, 08 May 2021 19:28:50 +0000

Medical studies about healthy living are very complex and not easy to draw clear conclusions from. But the evidence continues to grow on the benefits of a healthy Mediterranean diet.

Mediterranean diet may prevent memory loss and dementia, study finds

The true diet is simple, plant-based cooking, with the majority of each meal focused on fruits and vegetables, whole grains, beans and seeds, with a few nuts and a heavy emphasis on extra-virgin olive oil. Fats other than olive oil, such as butter, are consumed rarely, if at all. And say goodbye to refined sugar or flour.

Meat can make a rare appearance, but usually only to flavor a dish. Instead, meals may include eggs, dairy and poultry, but in much smaller portions than in the traditional Western diet. However, fish, which are full of brain-boosting omega-3’s, are a staple.
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“Eating a healthy plant-based diet is associated with better cognitive function and around 30% to 35% lower risk of cognitive impairment during aging,” lead author Claire McEvoy, assistant professor at Queen’s University Belfast

I am skeptical of the size of the risk reduction. It is seems decades of health studies show that precise measures are not that trustworthy. But it does seem that there are many benefits to a Mediterranean diet.

This is actually a photo of a dinner I enjoyed while in Malaysia (which just is one I had easy access to add to this post)

I have been taking this into account in my eating. I try to eat much more green leafy vegetable (though more is from my very low levels before). I try to reduce the amount of meat and increase the amount of fish and nuts. I try to eat enough fiber and I eat yogurt. I try to eat more fruits and vegetables in general. I try to reduce the amount of processed foods and sugar. My diet is far from great but it is much better than is was 20 years ago. I have probably been focused on doing better for over 10 years (post from 9 years ago: Healthy Diet, Healthy Living, Healthy Weight).

Simple Overview of Proteins

curiouscat — Tue, 20 Apr 2021 19:08:16 +0000

This webcasts provides a good, very simple, overview of proteins.

Learn more about proteins: How Lysozyme Protein in Our Tear-Drops Kill Bacteria – Molecular Motor Proteins – Fold.it, the Protein Folding Game

Huge Proposed Increases in USA Government Science and Engineering Support

curiouscat — Sat, 03 Apr 2021 23:12:26 +0000

The Biden administration has proposed greatly increasing USA government spending on science and engineering. They are proposing levels last seen in the 1960s when the USA was most committed to science and engineering spending (as most visibly seen in support for NASA).

Advance U.S. leadership in critical technologies and upgrade America’s research infrastructure. U.S. leadership in new technologies—from artificial intelligence to biotechnology to computing—is critical to both our future economic competitiveness and our national security. Based on bipartisan proposals, President Biden is calling on Congress to invest $50 billion in the National Science Foundation (NSF), creating a technology directorate that will collaborate with and build on existing programs across the government. It will focus on fields like semiconductors and advanced computing, advanced communications technology, advanced energy technologies, and biotechnology. He also is calling on Congress to provide $30 billion in additional funding for R&D that spurs innovation and job creation, including in rural areas. His plan also will invest $40 billion in upgrading research infrastructure in laboratories across the country, including brick-and-mortar facilities and computing capabilities and networks. These funds would be allocated across the federal R&D agencies, including at the Department of Energy. Half of those funds will be reserved for Historically Black College and Universities (HBCUs) and other Minority Serving Institutions, including the creation of a new national lab focused on climate that will be affiliated with an HBCU.

Establish the United States as a leader in climate science, innovation, and R&D. The President is calling on Congress to invest $35 billion in the full range of solutions needed to achieve technology breakthroughs that address the climate crisis and position America as the global leader in clean energy technology and clean energy jobs. This includes launching ARPA-C to develop new methods for reducing emissions and building climate resilience, as well as expanding across-the-board funding for climate research. In addition to a $5 billion increase in funding for other climate-focused research, his plan will invest $15 billion in demonstration projects for climate R&D priorities, including utility-scale energy storage, carbon capture and storage, hydrogen, advanced nuclear, rare earth element separations, floating offshore wind, biofuel/bioproducts, quantum computing, and electric vehicles, as well as strengthening U.S. technological leadership in these areas in global markets.

Eliminate racial and gender inequities in research and development and science, technology, engineering, and math. Discrimination leads to less innovation: one study found that innovation in the United States will quadruple if women, people of color, and children from low-income families invented at the rate of groups who are not held back by discrimination and structural barriers. Persistent inequities in access to R&D dollars and to careers in innovation industries prevents the U.S. economy from reaching its full potential. President Biden is calling on Congress to make a $10 billion R&D investment at HBCUs and other MSIs. He also is calling on Congress to invest $15 billion in creating up to 200 centers of excellence that serve as research incubators at HBCUs and other MSIs to provide graduate fellowships and other opportunities for underserved populations, including through pre-college programs.

This text is from The White House Infrastructure Plan (The American Jobs Plan). Likely this link will stop working in several years (once a new administration takes over.

I have written a great deal about the importance of science and engineering to the long term economic success of the USA and other countries. See the related links below. I support greatly increasing the USA government spending on science and engineering. I also support the current administration’s practice of making policy decisions based on an understanding of the current scientific understanding. I haven’t had a chance to look at the targeting of spending and I am sure I would have adjustments if it were up to me where to focus investments but the overall thrust of the current administration would be a great benefit to the USA economy over the next few decades.

As I have said before the USA has been living off of scientific investments made over 50 years ago for many decades. Our failures to prioritize science and engineering over the last few decades has been very costly and those costs are increasing rapidly. I hope we again prioritize the importance of science and engineering.

Choosing Between Chemical Engineering and Bioengineering

guestpost — Thu, 18 Feb 2021 01:06:42 +0000

Chemical engineering and bioengineering, also called biomedical engineering, overlap in some areas because they both create new technology and innovations for the healthcare industry. However, the two disciplines are very different. Here is a comparison of the two careers to help you choose the one that would be best for you.

What Does a Chemical Engineer Do?

A chemical engineer uses science to find solutions to problems, such as manufacturing issues for a food company. They can also work for pharmaceutical, chemical, science, petroleum, coal, oil, gas, trade, manufacturing and other companies.

They usually work in a laboratory or office setting. Sometimes they have to work in an industrial or chemical plant. Some chemical engineers work in the field, such as a refinery. The daily tasks of a chemical engineer can vary, but they usually include research and testing. They may develop new chemicals products, or they may create and test equipment.

Sometimes chemical engineers can solve important problems that affect different aspects of people’s lives. For example, Líney Árnadóttir is a chemical engineering associate professor who studies chemical processes on different surfaces to try to uncover how and why materials degrade.

Árnadóttir and other researchers used supercomputers to study chloride’s role in corrosion. Chemical engineers sometimes use technology, such as the supercomputers at the San Diego Supercomputer Center and the Texas Advanced Computing Center, to do their work and solve problems. By understanding how chloride affects materials like steel, the researchers can help companies, manufacturers and the environment deal with corrosion better.

What Is Bioengineering?

Bioengineering is a field that uses engineering to study and design biomedical technology and systems. A bioengineer usually works in healthcare. They frequently make new medical devices, equipment, software, computer systems and other products to help people.

Bioengineers can create new laboratory machines to diagnose medical problems or artificial organs to replace the ones in a person. It is possible for a bioengineer to find work in a laboratory, research center, manufacturing facility, hospital or university. Some bioengineers work for large companies and help them develop new products.

Every time you go to a doctor’s office or hospital you are seeing examples of bioengineering. When you need an MRI or CT scan, you are using technology built by bioengineers. If you need a hip replacement or a new knee, you are also benefiting from the designs created by bioengineers.

What Type of Qualifications Does Each Require?

In addition to studying engineering and chemistry, a chemical engineer must study math, biology and physics. As a student, you may have to study science topics like engineering computation or chemical engineering thermodynamics. A strong science and math background is important for becoming a chemical engineer. Many pursue a master’s degree after their bachelor’s degree.

A chemical engineer has to be a good problem solver. They have to look at a process or design and figure out how to make it work. They also have to fix it and figure out why it is not working when problems develop. Creativity is essential for this career.

A bioengineer must study engineering, biology and medical science. Additional topics studied by bioengineers include: genetics, computational biology and cell biology. Bioengineers will also must study math and other subjects during college. Many choose to pursue a master’s in biomedical engineering after earning their bachelor’s.

It is important for bioengineers to have a good understanding of the human body and healthcare. They often work with medical devices, so they have to know how people will use them and benefit from them. A good background in biology is helpful for anyone pursuing this field.

Salary Expectations

In general, engineering is considered to be one of the higher paying career fields that you can choose. The U.S. Bureau of Labor Statistics (BLS) shares that a typical chemical engineer earns $108,770 per year or $52 per hour. Some earn more depending on the field they work in, such as manufacturing or petroleum.

The U.S. Bureau of Labor Statistics lists $91,410 per year or $44 per hour as the typical salary for a bioengineer. There you work can affect how much you earn, and those in academic settings tend to earn less.

For example, if you compare job listings for bioengineers in larger companies to smaller ones or academic centers, you will see difference in pay. Bigger businesses tend to pay more and have higher bonuses for new workers.

If you are considering a career in chemical engineering or bioengineering, both require a strong background in science and math. However, there are differences between the two career paths that are worth exploring. The key is to find a career that fulfills you while providing a good salary and daily work environment.

Photos from This is Engineering

Creating Low-cost Construction Materials Using Recycled Plastic Waste

curiouscat — Fri, 12 Feb 2021 21:08:48 +0000

Nzambi Matee is a materials engineer and head of Gjenge Makers (in Kenya), which produces sustainable low-cost construction materials made of recycled plastic waste and sand. For her work, Nzambi Matee was recently named a Young Champions of the Earth by the United Nations Environment Programme.

Building blocks for a greener Nairobi

Through trial and error, she and her team learned that some plastics bind together better than others. Her project was given a boost when Matee won a scholarship to attend a social entrepreneurship training programme in the United States of America. With her paver samples packed in her luggage, she used the material labs in the University of Colorado Boulder to further test and refine the ratios of sand to plastic.

It is wonderful to see young people using an understanding of engineering to find ways to improve the world. Taking waste plastic and creating usable products will help reduce pollution and create a better world. We need quite a bit of effort to deal with plastic waste, so I look forward to learning about many more ideas turned into practical solutions in the real world.