Category Archives: Research

2011 Nobel Prize in Chemistry

Dan Shechtman, Israel Institute of Technology, 2011 Nobel Laurette in Chemistry

The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry for 2011 to Dan Shechtman, Technion – Israel Institute of Technology, Haifa, Israel for the discovery of quasicrystals.

In quasicrystals, we find the fascinating mosaics reproduced at the level of atoms: regular patterns that never repeat themselves. However, the configuration found in quasicrystals was considered impossible, and Dan Shechtman had to fight a fierce battle against established science. The Nobel Prize in Chemistry 2011 has fundamentally altered how chemists conceive of solid matter.

On the morning of 8 April 1982, an image counter to the laws of nature appeared in Dan Shechtman’s electron microscope. In all solid matter, atoms were believed to be packed inside crystals in symmetrical patterns that were repeated periodically over and over again. For scientists, this repetition was required in order to obtain a crystal.

Shechtman’s image, however, showed that the atoms in his crystal were packed in a pattern that could not be repeated. Such a pattern was considered just as impossible as creating a football using only six-cornered polygons, when a sphere needs both five- and six-cornered polygons. His discovery was extremely controversial. In the course of defending his findings, he was asked to leave his research group. However, his battle eventually forced scientists to reconsider their conception of the very nature of matter.

Aperiodic mosaics, such as those found in the medieval Islamic mosaics of the Alhambra Palace in Spain and the Darb-i Imam Shrine in Iran, have helped scientists understand what quasicrystals look like at the atomic level. In those mosaics, as in quasicrystals, the patterns are regular – they follow mathematical rules – but they never repeat themselves.

When scientists describe Shechtman’s quasicrystals, they use a concept that comes from mathematics and art: the golden ratio. This number had already caught the interest of mathematicians in Ancient Greece, as it often appeared in geometry. In quasicrystals, for instance, the ratio of various distances between atoms is related to the golden mean.

Following Shechtman’s discovery, scientists have produced other kinds of quasicrystals in the lab and discovered naturally occurring quasicrystals in mineral samples from a Russian river. A Swedish company has also found quasicrystals in a certain form of steel, where the crystals reinforce the material like armor. Scientists are currently experimenting with using quasicrystals in different products such as frying pans and diesel engines.

Read more on the science he has worked on. Our understanding of science is built on the discoveries of our predecessors and on the discoveries that counter what we thought we knew.
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2011 Nobel Prize in Physics

Photos of the 2011 Physics Nobel Prize Winners.

The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Physics for 2011 with one half to

Saul Perlmutter
The Supernova Cosmology Project, Lawrence Berkeley National Laboratory and University of California, Berkeley, CA, USA

and the other half jointly to

Brian P. Schmidt
The High-z Supernova Search Team, Australian National University, Weston Creek, Australia

and

Adam G. Riess
The High-z Supernova Search Team, Johns Hopkins University and Space Telescope Science Institute, Baltimore, MD, USA

“for the discovery of the accelerating expansion of the Universe through observations of distant supernovae”

Once again the USA dominates the physics category, Brian Schmidt is a USA and Australian citizen. It will be interesting to see if this starts to change in the next decade. I believe it will at some point fairly soon, the question is at what point.

“Some say the world will end in fire, some say in ice…” Robert Frost, Fire and Ice, 1920

What will be the final destiny of the Universe? Probably it will end in ice, if we are to believe this year’s Nobel Laureates in Physics. They have studied several dozen exploding stars, called supernovae, and discovered that the Universe is expanding at an ever-accelerating rate. The discovery came as a complete surprise even to the Laureates themselves.

In 1998, cosmology was shaken at its foundations as two research teams presented their findings. Headed by Saul Perlmutter, one of the teams had set to work in 1988. Brian Schmidt headed another team, launched at the end of 1994, where Adam Riess was to play a crucial role.

The research teams raced to map the Universe by locating the most distant supernovae. More sophisticated telescopes on the ground and in space, as well as more powerful computers and new digital imaging sensors (CCD, Nobel Prize in Physics in 2009), opened the possibility in the 1990s to add more pieces to the cosmological puzzle.

The teams used a particular kind of supernova, called type Ia supernova. It is an explosion of an old compact star that is as heavy as the Sun but as small as the Earth. A single such supernova can emit as much light as a whole galaxy. All in all, the two research teams found over 50 distant supernovae whose light was weaker than expected – this was a sign that the expansion of the Universe was accelerating. The potential pitfalls had been numerous, and the scientists found reassurance in the fact that both groups had reached the same astonishing conclusion.

For almost a century, the Universe has been known to be expanding as a consequence of the Big Bang about 14 billion years ago. However, the discovery that this expansion is accelerating is astounding. If the expansion will continue to speed up the Universe will end in ice.

The acceleration is thought to be driven by dark energy, but what that dark energy is remains an enigma – perhaps the greatest in physics today. What is known is that dark energy constitutes about three quarters of the Universe. Therefore the findings of the 2011 Nobel Laureates in Physics have helped to unveil a Universe that to a large extent is unknown to science. And everything is possible again.

As usually the Nobel committee does a great job of providing the public open scientific information. Others that claim to promote science can learn from them. They do a great job of making the science understandable to a lay person.

The discovery came as a complete surprise even to the Nobel Laureates themselves. What they saw would be like throwing a ball up in the air, and instead of having it come back down, watching as it disappears more and more rapidly into the sky, as if gravity could not manage to reverse the ball’s trajectory. Something similar seemed to be happening across the entire Universe.

The growing rate of the expansion implies that the Universe is being pushed apart by an unknown form of energy embedded in the fabric of space. This dark energy makes up a large part of the Universe, more than 70 %, and it is an enigma, perhaps the greatest in physics today. No wonder, then, that cosmology was shaken at its foundations when two different research groups presented similar results in 1998.
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2011 Nobel Prize in Physiology or Medicine

The Nobel Assembly at Karolinska Institutet has today decided that The Nobel Prize in Physiology or Medicine 2011 shall be divided, with one half jointly to Bruce A. Beutler and Jules A. Hoffmann for their discoveries concerning the activation of innate immunity and the other half to Ralph M. Steinman for his discovery of the dendritic cell and its role in adaptive immunity.

This year’s Nobel Laureates have revolutionized our understanding of the immune system by discovering key principles for its activation.

Scientists have long been searching for the gatekeepers of the immune response by which man and other animals defend themselves against attack by bacteria and other microorganisms. Bruce Beutler and Jules Hoffmann discovered receptor proteins that can recognize such microorganisms and activate innate immunity, the first step in the body’s immune response. Ralph Steinman discovered the dendritic cells of the immune system and their unique capacity to activate and regulate adaptive immunity, the later stage of the immune response during which microorganisms are cleared from the body.

The discoveries of the three Nobel Laureates have revealed how the innate and adaptive phases of the immune response are activated and thereby provided novel insights into disease mechanisms. Their work has opened up new avenues for the development of prevention and therapy against infections, cancer, and inflammatory diseases.

We live in a dangerous world. Pathogenic microorganisms (bacteria, virus, fungi, and parasites) threaten us continuously but we are equipped with powerful defense mechanisms (please see image below). The first line of defense, innate immunity, can destroy invading microorganisms and trigger inflammation that contributes to blocking their assault. If microorganisms break through this defense line, adaptive immunity is called into action. With its T and B cells, it produces antibodies and killer cells that destroy infected cells. After successfully combating the infectious assault, our adaptive immune system maintains an immunologic memory that allows a more rapid and powerful mobilization of defense forces next time the same microorganism attacks. These two defense lines of the immune system provide good protection against infections but they also pose a risk. If the activation threshold is too low, or if endogenous molecules can activate the system, inflammatory disease may follow.

The components of the immune system have been identified step by step during the 20th century. Thanks to a series of discoveries awarded the Nobel Prize, we know, for instance, how antibodies are constructed and how T cells recognize foreign substances. However, until the work of Beutler, Hoffmann and Steinman, the mechanisms triggering the activation of innate immunity and mediating the communication between innate and adaptive immunity remained enigmatic.

Ralph Steinman was awarded the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity. He was born in Canada and was a professor at Rockefeller University at the end of his career.

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Faster Than Light Speed Anomaly Reported by CERN

The OPERA result is based on the observation of over 15000 neutrino events measured at Gran Sasso, and appears to indicate that the neutrinos travel at a velocity 20 parts per million above the speed of light, nature’s cosmic speed limit. Given the potential far-reaching consequences of such a result, independent measurements are needed before the effect can either be refuted or firmly established. This is why the OPERA collaboration has decided to open the result to broader scrutiny. The collaboration’s result is available on the preprint server arxiv.org.

The OPERA measurement is at odds with well-established laws of nature, though science frequently progresses by overthrowing the established paradigms. For this reason, many searches have been made for deviations from Einstein’s theory of relativity, so far not finding any such evidence. The strong constraints arising from these observations makes an interpretation of the OPERA measurement in terms of modification of Einstein’s theory unlikely, and give further strong reason to seek new independent measurements.

“This result comes as a complete surprise,” said OPERA spokesperson, Antonio Ereditato of the University of Bern. “After many months of studies and cross checks we have not found any instrumental effect that could explain the result of the measurement. While OPERA researchers will continue their studies, we are also looking forward to independent measurements to fully assess the nature of this observation.”

“When an experiment finds an apparently unbelievable result and can find no artefact of the measurement to account for it, it’s normal procedure to invite broader scrutiny, and this is exactly what the OPERA collaboration is doing, it’s good scientific practice,” said CERN Research Director Sergio Bertolucci. “If this measurement is confirmed, it might change our view of physics, but we need to be sure that there are no other, more mundane, explanations. That will require independent measurements.” This is a great reminder of the proper application of the scientific inquiry process. Our understanding moves forward based on evidence and incredible results require a high burden of proof before we accept them.

In order to perform this study, the OPERA Collaboration teamed up with experts in metrology from CERN and other institutions to perform a series of high precision measurements of the distance between the source and the detector, and of the neutrinos’ time of flight. The distance between the origin of the neutrino beam and OPERA was measured with an uncertainty of 20 cm over the 730 km travel path. The neutrinos’ time of flight was determined with an accuracy of less than 10 nanoseconds by using sophisticated instruments including advanced GPS systems and atomic clocks. The time response of all elements of the CNGS beam line and of the OPERA detector has also been measured with great precision.

“We have established synchronization between CERN and Gran Sasso that gives us nanosecond accuracy, and we’ve measured the distance between the two sites to 20 centimetres,” said Dario Autiero, the CNRS researcher who will give this afternoon’s seminar. “Although our measurements have low systematic uncertainty and high statistical accuracy, and we place great confidence in our results, we’re looking forward to comparing them with those from other experiments.”

“The potential impact on science is too large to draw immediate conclusions or attempt physics interpretations. My first reaction is that the neutrino is still surprising us with its mysteries.” said Ereditato. “Today’s seminar is intended to invite scrutiny from the broader particle physics community.”

The OPERA experiment was inaugurated in 2006, with the main goal of studying the rare transformation (oscillation) of muon neutrinos into tau neutrinos. One first such event was observed in 2010, proving the unique ability of the experiment in the detection of the elusive signal of tau neutrinos.

This is great stuff, wether it turns out to be an amazing result that changes our understanding of physics or even if it doesn’t (if it turns out the apparent result is not what it seems). It is great to see us attempt to learn. My guess is that we find some explanation for the anomaly that does avoids something traveling faster than the speed of light.

Brian Cox on the BBC 6: “This is the way science works, we go away and do it again and check, and then do it again and check. If it is confirmed then it will be the most significant discovery in physics in the last, at least, 100 years.”

Molecule Found in Sharks Kills Many Viruses that are Deadly to People

photo of 3 dogfish sharks
Shark Molecule Kills Human Viruses, Too

“Sharks are remarkably resistant to viruses,” study researcher Michael Zasloff, of the Georgetown University Medical Center, told LiveScience. Zasloff discovered the molecule, squalamine, in 1993 in the dogfish shark, a small- to medium-size shark found in the Atlantic, Pacific, and Indian Oceans.

“It looked like no other compound that had been described in any animal or plant before. It was something completely unique,” Zasloff said. The compound is a potent antibacterial and has shown efficacy in treating human cancers and an eye condition known as macular degeneration, which causes blindness.
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By studying the compound’s structure and how it works in the human body, Zasloff thought it might have some antiviral properties. He saw that the molecule works by sticking to the cell membranes of the liver and blood vessels. While there, it kicks off other proteins, some of which are essential for viruses to enter and survive in the cell.

The researchers decided to test the compound on several different live viruses that infect liver cells, including hepatitis B, dengue virus and yellow fever. They saw high efficacy across the board.
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Zasloff hopes to start human trials in the next few years.
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Marc Maresca, a researcher at Paul CÃ©zanne University in Aix-en-Provence, France, who wasn’t involved in the study, agreed that the concentrations used were quite high, possibly in toxic ranges for some cells, but in an email to LiveScience Meresca also called the study “very exciting.”

Amber Pieces Containing Remains from Dinosaurs and Birds Show Feather Evolution

Dinosaur feather evolution trapped in Canadian amber

a study of amber found near Grassy Lake in Alberta – dated from what is known as the Late Cretaceous period – has unearthed a full range of feather structures that demonstrate the progression. “We’re finding two ends of the evolutionary development that had been proposed for feathers trapped in the same amber deposit,” said Ryan McKellar of the University of Alberta, lead author of the report.

The team’s find confirms that the filaments progressed to tufts of filaments from a single origin, called barbs. In later development, some of these barbs can coalesce into a central branch called a rachis. As the structure develops further, further branches of filments form from the rachis.

“We’ve got feathers that look to be little filamentous hair-like feathers, we’ve got the same filaments bound together in clumps, and then we’ve got a series that are for all intents and purposes identical to modern feathers,” Mr McKellar told BBC News.

“We’re catching some that look to be dinosaur feathers and another set that are pretty much dead ringers for modern birds.”
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a picture is emerging that many dinosaurs were not the dull-coloured, reptilian-skinned creatures that they were once thought to be. “If you were to transport yourself back 80 million years to western North America and walk around the forest… so many of the animals would have been feathered,” said Dr Norell.

“We’re getting more and more evidence… that these animals were also brightly coloured, just like birds are today.”

Very cool. Science really is great.

Robot Tennis Partners Coming Soon?

The robots in the video, and many more, are being tested at the Flying Machine Arena at the The Institute for Dynamic Systems and Control, Department of Mechanical and Process Engineering, Swiss Federal Institute of Technology – Zurich.

They also usually have a number of challenging projects available. Qualified, motivated students should visit the Theses/Projects page and contact them to learn more. We need more people working on these types of things so I can have my robot basketball team available when I want to play.

Cutting the Boarding Time of Planes in Half

I thought I wrote about this several years ago, but I guess I didn’t (I can’t find it, if I did). Experimental test of airplane boarding methods:

The Steen method, on the other hand, orders the passengers in such a way that adjacent passengers in line are sitting in corresponding seats two rows apart from each other (e.g., 12A, 10A, 8A, 6A, etc.). This method trades a small number of aisle interferences at the front of the cabin, for the beneï¬t of having multiple passengers stowing their luggage simultaneously. Other methods, such as Wilma and the Reverse Pyramid also realize parallel use of the aisle in a natural way as adjacent passengers are frequently sitting in widely separated rows.
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We have seen experimentally that there is a marked difference in the time required to board an aircraft depending upon the boarding method used. The evidence strongly supports the heuristic argument from Steen that methods that parallelize the boarding process by more efï¬ciently utilizing the aisle (having more passengers stow their luggage simultaneously) will board more quickly than those that do not. The relative beneï¬t of the application of this theory will grow with the length of the aircraft. Here, we used a 12-row mock airplane, but a more typical airplane with twice that number of rows will gain more by the implementation of parallelized boarding methods.

How this improvement scales with the cabin length is different for each method. For the Steen method, the beneï¬t will scale almost linearly. If the airplane is twice as long, the time savings will be nearly twice as much since the density of luggage-stowing passengers will remain the same and the boarding will still be maximally parallel. For Wilma and random boarding the beneï¬t will not be as strong since the beneï¬ts of parallel boarding are randomly distributed along the length of the cabin instead of being regularly distributed.

I am not optimistic that airlines will even test out this method. People tend to think companies apply sensible, proven concepts and methods. But that is much less likely to be done than people think. The failure of many places to use simple queuing theory improvement (customers should form one line and be served the next available person not form many individual lines) is one example of failures by companies to apply decades old proven better methods. The poor adoption of multivariate designed experiments is another. Applying better ideas is a process that is not done very efficiently in business, health care, education or even science and engineering – in fact in any human endeavor. This is a waste that impacts each of us every day. It is also an opportunity for you to gain advantages just by applying all the good ideas lying around that others are ignoring. You need to test the ideas out in your setting (using the PDSA cycle in an organizational context a good method).

The Politics of Anti-Science

In the 1960’s the USA had an unrealistic view of how much studying and learning about science and engineering could do. Investing is science and engineering is an extremely wise economic (and cultural) endeavor but it isn’t going to solve all the problems that exist. Somehow today we find ourselves with a large number of politically powerful people we take strong anti-science positions. These tactics reduce funding and support for beneficial research and are short sited approaches to public administration. This is an unfortunate turn of events that is damaging the American economy and will have huge damages going forward.

Thankfully other countries have seen how wise investing in science and engineering is and have more than taken up the slack created by the anti-science community. Two favorite tactics of the anti-science leaders is to try and create confusion where there is none and to turn the focus away from serious matters and instead playing silly political games. The silly games will draw donors and voters so if they care about those things more than the country and the future of the country it is a sound tactic. The damage it causes the country however I would hope would limit the use of such tactics however that has not been the case recently.

‘Shrimp On A Treadmill’: The Politics Of ‘Silly’ Studies

Take the case of the “shrimp on a treadmill.” Burnett says the senator’s report linked that work to a half-million-dollar research grant. But that money actually went to a lot of different research that he and his colleagues did on this economically important seafood species.

The treadmills were just a small part of it, a way to measure how shrimp respond to changes in water quality. Burnett says the first treadmill was built by a colleague from scraps and was basically free, and the second was fancier and cost about $1,000. The senator’s report was misleading, says Burnett, “and it suggests that much money was spent on seeing how long a shrimp can run on a treadmill, which was totally out of context.”

John Hart, a Coburn spokesperson, said in an email that “our report never claimed all the money was spent on shrimp on a treadmill. The scientists doth protest too much. Receiving federal funds is a privilege, not a right. If they don’t want their funding scrutinized, don’t ask.”

What the politicians are doing is exactly what this spokesperson suggests – they are withdrawing from the anti-science culture created by some in Washington: they are moving their research to countries that support rather than attack science. That is a very bad thing for the USA. There are a number of very bad economic policies a government can take. Driving scientists and engineers into the arms of other countries is one of the worst.
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New Life Form Found at South African Truck Stop

Man discovers a new life-form at a South African truck stop

An order is one of the big categories of life, a big branch on evolution’s tree. Animal species are named every day, but finding another new order would be equivalent to discovering bats having not previously known they existed. Bats constitute their own order, as do primates, beetles, flies and rodents.
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The Mantophasmatodes look, inescepably, larval (they lack wings, for example, and have no ocelli) and so Picker like others mistook them for immature versions of some known creature, perhaps some weird kind of cricket. When more than three quarters of all species of animals are not yet named, it is hard to know which ones to get excited about finding. Picker went through his collections looking for specimens of Mantophasmatodes. Within weeks, he had found twenty-nine individual Mantophasmatodes. Thirteen living species of Mantophasmatodea have now been named and placed in 10 genera and three different families.

In other words, Zompro has done something more amazing than finding a rare new order of animals. He has discovered a common order of animals that everyone else had missed, a discovery in plain view.

Mantaphasmatodes are not a far away species confined to some remote hunk of rock. They are a whole suite of species, some of which live places as mundane as backyards. They are also a kind of a living extended metaphor for what lurks around us unnoticed all the time.

I was always told as a child that I shouldn’t question so much and just accept what adults have decided. I am sure I was very annoying questioning everything. Especially how amazingly boring they make school. I love learning stuff. In general I did not love school. But questioning that school really should do a better job of making it fun to learn was seen as being a bothersome kid. I should just accept this is how school is and learn. I still think I was right. School is horribly designed to nurture the innate curiosity of people. Rather than seeing the kids that point this out as troublemakers we should see those that perpetuate the current system as troublemakers.

I still remember my sophomore year in high school I was taught by a biology teacher that new very little. They had been a 2nd grade teacher for like 15 years and due to seniority (they didn’t need as many 2nd grade teachers I guess) she bumped the biology teacher from the year before and we were stuck learning from her. In fact, any decently interesting question was more likely to be answered by a student (Peter – who then went to Princeton and then to play for the National Symphony) after the teacher said she didn’t know.

I found biology horrible. And it probably took a decade or more for me to finally notcie how amazingly cool biology. Fantastically cool. The amount of just super interesting biology is so vast that I have huge amounts of great stuff I get to look forward to learning. My teacher made it even worse, but frankly the way it is taught (I would imagine) is pretty bad even if the teacher is good. My high school was populated largely by the kids of Professors and compared to other schools in the USA I was told many times was fantastic (and the data seemed to support that – I believe we have more national merit scholars the year I graduated than all but 1 other public school in the country).

We need to do a much better job of harnessing the native desire to learn people have instead of killing it (which we do far to often). It really is a tragedy. It isn’t noticed because you can get by alright without loving learning. But it reduces the lives people have when they have their love of learning crushed. I didn’t have mine crushed but when I look around at many adults they seem to have done so to a large extent (sometimes it pokes through in a hobby or with their kids). And of course many adults kept a strong love of learning (all those geeks for example – and don’t forget the biologists).