Author Archives: curiouscat

Millennials in our Lifetime?

No I don’t mean the generation Y types born in the 1980s and 1990s I mean 1,000 year old people. I doubt it, but according to Cambridge University geneticist Aubrey de Grey – yes. And his credentials are better than mine, well I guess some of us might see who is right. ‘We will be able to live to 1,000’. Do You Want to Live Forever?:

As he surveyed the literature, de Grey reached the conclusion that there are seven distinct ingredients in the aging process, and that emerging understanding of molecular biology shows promise of one day providing appropriate technologies by which each of them might be manipulated — “perturbed,” in the jargon of biologists. He bases his certainty that there are only seven such factors on the fact that no new factor has been discovered in some twenty years, despite the flourishing state of research in the field known as biogeronÂtology, the science of aging; his certainty that he is the man to lead the crusade for endless life is based on his conception that the qualification needed to accomplish it is the mindset he brings to the problem: the goal-driven orientation of an engineer rather than the curiosity-driven orientation of the basic scientists who have made and will continue to make the laboratory discoveries that he intends to employ.

Aubrey de Grey Responds – Methuselah Mouse Man – Aubrey de Grey on TEDTalks: Aging is “an engineering problem” – The Prophet of Immortality

Educating Engineers for 2020 and Beyond

Educating Engineers for 2020 and Beyond by Charles M. Vest, President Emeritus, MIT Professor, Department of Mechanical Engineering (nominated to become the President of the National Academy of Engineering, with a term starting in July 2007). A 70 minute videocast:

To prepare this new generation, engineering schools should focus on creating an environment that provides inspiration. In the long run, offering “exciting, creative adventures, rigorous, demanding and empowering milieus is more important than specifying details of the curriculum,” says Vest. Students are “driven by passion, curiosity, engagement and dreams.” Give them opportunities to discover and do – to participate in research teams, perform challenging work in industry, gain professional experience in other countries. Vest says, “We must ensure the best and brightest become engineers of 2020 and beyond. We can’t afford to fail.”

via: Video: Former MIT President on the future of engineering education

Science, Engineering and the Future of the American Economy

9 leaders (Craig Barrett, Charles Vest, Scott McNealy, Gururaj “Desh” Deshpande, Judith Rodin, Rick Rashid, Nick Donofrio, Dr. Ralph Wyndrum Jr. and Lou Dobbs) share their thoughts in Keeping Research and Leadership at Home by Vivek Wadhwa:

[several] stress the need to improve K-12 education, encourage students to study more math and engineering, bring in the best and brightest talent from around the world, and up the ante in basic research.
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Craig Barrett, Intel chairman – Currently we have lost the race in K-12 education, we are losing our position as a top educator of science, technology, engineering and mathematics students, we are losing our lead in university research, and we have our head in the sand on government policy.
…
Gururaj “Desh” Deshpande, Sycamore Networks co-founder and chairman – We believe that all of this greatly increases the chances of a particular innovation having impact. Such sophisticated systems can only be developed in the U.S. because it is the only country with both flexible thinking and free markets.
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Charles Vest, former president of MIT, president-elect of the National Academy of Engineering – We’re on top, but our share of the world’s R&D spending, new patents, scientific publications, researchers, and BA and PhD. degrees in science and engineering are all dropping. We need to start right now to strengthen investment in basic research, get serious about K-12 education, especially in math and science, and attract more of our best and brightest young men and women into what will be crucial and exciting careers in engineering and science.

In previous posts I discuss my thoughts on the important topics of science, engineering and the economy: The Future is Engineering – Science and Engineering in Global Economics – Engineering the Future Economy – Diplomacy and Science Research – Economics and Science and Engineering – U.S. Slipping on Science
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Asia: Rising Stars of Science and Engineering

Great report – The Atlas of Ideas: How Asian innovation can benefit us all by Charles Leadbeater and James Wilsdon:

Each country will develop differently. In South Korea strong government support has created a world-class information infrastructure.
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China is mobilising massive resources for innovation through ambitious long-term plans, funded by rapid economic growth. Beijing’s university district produces as many engineers as all of western Europe. China is developing world-class universities and attracting multinational innovation centres.
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India’s elite, trained at the Indian Institutes of Technology, are second to none. New institutions like the National Science and Engineering Foundation could energise a disjointed innovation system. Yet India’s innovation elite may face a rural backlash. Its infrastructure is in poor repair and cities like Bengalooru are congested. Even the much-vaunted IITs do not, unlike their US counterparts, animate innovation clusters.

Percentage of world share of scientific publications

Year	China	France	Germany	Japan	Korea	UK	US	EU-15
1995	2.05	6.09	7.62	8.65	0.79	8.88	33.54	34.36
1998	2.90	6.48	8.82	9.42	1.41	9.08	31.63	36.85
2001	4.30	6.33	8.68	9.52	2.01	8.90	31.01	36.55
2004	6.52	5.84	8.14	8.84	2.70	8.33	30.48	35.18

Excellent reading, the report is full of useful information I have not been able to obsorb yet.
Related: Diplomacy and Science Research – The World’s Best Research Universities – Engineering the Future Economy – Worldwide Science and Engineering Doctoral Degree Data – USA Under-counting Engineering Graduates – Increasing American Fellowship Support for Scientists and Engineers
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Get Your Own Science Art

hemoglobin represented in crystal

Cool science art from Bathsheba Sculpture.

The Molecule that Makes Breathing Worthwhile – Hemoglobin is the iron-bearing protein that most animals use to carry oxygen from their lungs to their muscles, or wherever it’s needed for metabolism, i.e. life. It’s the most important part of red blood cells, and its iron is what makes them red.

This sculpture, etched in a heavy 3 1/4″ glass cube, shows hemoglobin’s beautiful structure: the four heme groups each with its iron atom, the two alpha and two beta subunits, and the translucent molecular surface over all.

As well as being handsome and useful, hemoglobin is a star of scientific history. With its close relative myoglobin, it was the first protein to have its 3D structure determined by X-ray crystallography. Max Perutz and John Kendrew at Cambridge University received the Nobel Prize in 1962 for doing it.

The site offers various crystals and sculptures created by Bathsheba Grossman. The art itself is very cool and the site includes interesting information on the science represented by the art and the engineering behind creating the art.

The points are tiny (.1mm) fractures created by a focused laser beam. The conical beam, with a focal length of about 3”³, shines into the glass without damaging it except at the focal point. At that one point, concentrated energy heats the glass to the cracking point, causing a microfracture.

To draw more points, the laser is pulsed on and off. To make the beam move between points, it’s reflected from a mirror that is repositioned between pulses. The mirror is moved by computer-controlled motors, so many points can be drawn with great speed and accuracy. A typical design might use several hundred thousand points, or half a million isn’t unusual in a large block, each placed with .001”³ accuracy.

Create Your Own Book

I received a custom made photo book from my brother. It is amazing. It is a hardcover book, full of photos. The quality is amazing. The book is printed by blurb. Looking on their web site the pricing is surprisingly cheap: 150 page full color hardcover book – $39.95 (for 1 copy! – 10% discount at 25 copies…), as little as $18.95 for a full color softcover book up to 40 pages. The site says books are normally printed in under a week.

I have not tried it but it appears printing your own great looking book is about as easy as creating a blog. I knew it was getting easier to print books, but still I find this very cool. Blurb can import photos from Flickr and Picasa.

This technology enabled self publishing also brings us: The Best Writing on Science Blogs 2006, using lulu: “Lulu is fast, easy and free, No set-up fees. No minimum order. Keep control of the rights. Set your own price. Each product is printed as it is ordered. No excess inventory.”

Lethal Secrets of 1918 Flu Virus

Lethal secrets of 1918 flu virus

Analysis at the University of Wisconsin at Madison (UW) revealed that a key component of the immune system, a gene called RIG-1 appeared to be involved. Levels of the protein produced by the gene were lower in tissue infected with the 1918 virus, suggesting it had a method of switching it off, causing immune defences to run wild.

This ability to alter the body’s immune response is shared with the most recent candidate for mutation into a pandemic strain, the H5N1 avian flu. Experts are worried that if the virus changes so that it can infect humans easily, it could again be far more lethal than normal seasonal flu. “What we see with the 1918 virus in infected monkeys is also what we see with H5N1 viruses,” said Yoshihiro Kawaoka, who led the analysis at UW.

Cancer Deaths – Declining Trend?

3,000 fewer cancer deaths:

Cancer deaths in the United States dropped for the second year in a row, health officials reported yesterday, confirming that the trend is real and becoming more pronounced, too.

The news was cause for celebration among doctors and politicians. “When we saw the first decline, the number wasn’t that enormous,” Dr. Felice Schnoll-Sussman, a cancer physician at New York-Presbyterian Hospital/Weill Cornell Medical Center said. “But once you start to see a trend like this, it obviously makes you feel like ‘We must be doing something right! ‘”

Is this really a trend? I have not examined the data at all but I seriously doubt it. People (the media even more so) constantly overreact to variation in data. Maybe I am wrong, certainly I should look at the data and see what it says – and I will if I get some time and remember. But I am more confident in my belief this is more overreaction to random variation than in the headlines. Why? Because so often when I do look more closely at the numbers my general observation of overreaction to random variation is confirmed while news reports talk of “trends.” Hopefully I am wrong this time.

Ok, I couldn’t resist and I did a little looking for some data. This is how crazy it is. The press release from the American Cancer Society states:
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Cheap, Safe Cancer Drug?

Cheap, safe drug kills most cancers:

It sounds almost too good to be true: a cheap and simple drug that kills almost all cancers by switching off their “immortality”. The drug, dichloroacetate (DCA), has already been used for years to treat rare metabolic disorders and so is known to be relatively safe. It also has no patent, meaning it could be manufactured for a fraction of the cost of newly developed drugs.

Well I have been told I am too skeptical, but it does sound too good to be true. How many stories of cancer cures do we hear every year? Even if the drug companies leave it alone (I would imagine they could easily find ways to have drugs that partially rely on this and partially on things they can patent, but anyway…) foundations and universities will invest in it if it is truly deserving. Now maybe I am being too optimistic?

MIT Media Lab Releases Scratch

Scratch is a new programmable toolkit that enables kids to create their own games, animated stories, and interactive art — and share their creations with one another over the Net.

Scratch is designed especially for youth at Computer Clubhouses, an international network of after-school centers in low-income communities. The Scratch project aims to create a programming culture at Computer Clubhouses, empowering youth (ages 10-16) to express themselves fluently and creatively with new technologies.