Category Archives: Engineering

Engineered Immune Cells Shrink Tumors

Tumors Shrunk by Engineered Immune Cells, Scientists Say by Stefan Lovgren, on an extermintal treatment with 17 patients so far:

“This is the first example of an effective gene therapy that works in cancer patients,” said Steven Rosenberg, chief of surgery at the National Cancer Institute in Bethesda, Maryland, and leader of the research team.

The therapy has so far been applied only to melanoma patients. But the researchers are optimistic that their treatment can be used for many other types of cancer.

The team has already engineered similar immune cells for more common tumors, such as breast, lung, and liver cancers.
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His team focused on T (thymus) cells, a type of specialized immune cell that can learn to recognize and attack specific “foreign” objects, such as the cancer cells that make up tumors.

In the new study, researchers created tumor-fighting cells by harvesting normal T cells from melanoma patients and genetically engineering these cells to carry receptor proteins on their surfaces that recognize cancer markers.

Ocean Power Plant

Interest in ocean power resurges by Dennis Camire via A new wave of interest in ocean power:

Ocean thermal power plants, which generate electricity from the temperature difference between the tropics’ warm surface water and deep cold water, could be built on land in several hundred areas around the globe’s equatorial zones and also could be constructed as floating plants.
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A recent Electric Power Research Institute study found sites in Maine, Alaska, California and Washington that had good potential for tidal power generation with production costs ranging from 4.2 cents per kilowatt hour to 10.8 cents. By comparison, the average retail cost of electricity to U.S. consumers in May was 8.64 cents per kilowatt hour.

Research Career in Industry or Academia

In, Working in Industry vs Working in Academia, a computer scientist (software engineering) shares their experience and opinion on research career options. He discusses 4 areas: freedom (to pursue your research), funding, time and scale, products (papers, patents, products).

In academia, you’re under a huge amount of pressure to publish publish publish!
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In industry, the common saying is that research can produce three things: products, patents, and papers (in that order). To be successful you need to produce at least two of those three; and the first two are preferred to the last one. Publishing papers is nice, and you definitely get credit for it, but it just doesn’t compare to the value of products and patents.

Civil Engineers: USA Infrastructure Needs Improvement

Experts warn U.S. is coming apart at the seams by Chuck McCutcheon:

The American Society of Civil Engineers last year graded the nation “D” for its overall infrastructure conditions, estimating that it would take $1.6 trillion over five years to fix the problem.

“I thought [Hurricane] Katrina was a hell of a wake-up call, but people are missing the alarm,” said Casey Dinges, the society’s managing director of external affairs.

It will take much longer than 5 years: there is no way over $300 billion is available each year to catch up. Infrastructure is not an exciting area to invest in but just like skipping preventative maintenance on equipment will cost organizations more in the long run, failing to invest in maintaining the infrastructure will cost more.

“Infrastructure deficiencies will further erode our global competitiveness, but with the federal budget so committed to mandatory spending, it’s unclear how we are going to deal with this challenge as we fall further and further behind in addressing these problems,”

These “grade” evaluations are a bit flaky: what does a D mean for the USA (they define it as “poor” which still doesn’t mean much)? Still, it is clear the ASCE sees a need for improvement. Related: 2005 ASCE report – Concord Coalition

Open Access Education Materials

Watch a video of Richard Baraniuk (Rice University professor speaking at TED) discussing Connexions: an open-access education publishing system. The content available through Connexions includes short content modules such as:

What is Engineering??:

Engineering is the endeavor that creates, maintains, develops, and applies technology for societies’ needs and desires.
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One of the first distinctions that must be made is between science and engineering.
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Science is the study of what is and engineering is the creation of can be.

and: Protein Folding, as well as full courses, such as: Fundamentals of Electrical Engineering I and Physics for K-12.

Related: Google technical talk webcasts (including a presentation by Richard Baraniuk at Google) – podcasts of Technical Talks at Google – science podcast posts – Berkeley and MIT courses online

Extreme Engineering

Discovery Channels’ Extreme Engineering explores audacious engineering possibilities. The Extreme Engineering web site (broken by phb organization that can’t even keep a web page alive forget actually doing amazing stuff, so I removed it) provides a view of some of the exciting projects engineers have worked on like the new subways for New York City and Hong Kong’s airport. And it also shows some possible future projects like a transatlantic tunnel (image above) which would float in the ocean and carry trains, pipelines…. Trains could run in a vacuum and travel at 6-8,000 kph (taking under an hour to travel from New York City to London. Of course there are quite a few engineering and economic factors to deal with to make something like that a reality.

Wind Power

Wind Power graph

Graph of wind power capacity in the USA from 1981 – 2005 (from 10 Megawatts to 9,149 megawatts).

From the American Wind Energy Association:

The only other countries around the world that have more wind power installed are Germany (19,140 MW as of the end of June), and Spain (10,728 MW).

AWEA expects the U.S. to pass the 15,000 MW mark by the end of 2007 and can have 25,000 MW installed by the end of 2010, with the proper policies in place. At this growth rate, the U.S. could have 100,000 MW installed by 2020, which would provide the nation with approximately 6% of its future power needs, about as much as hydropower provides today.

Nanocars

Nano Car image

‘Nanocar’ with buckyball wheels paves way for other molecular machines

“The synthesis and testing of nanocars and other molecular machines is providing critical insight in our investigations of bottom-up molecular manufacturing,” said one of the two lead researchers, James M. Tour, the Chao Professor of Chemistry, professor of mechanical engineering and materials science and professor of computer science at Rice University. “We’d eventually like to move objects and do work in a controlled fashion on the molecular scale, and these vehicles are great test beds for that. They’re helping us learn the ground rules.”

The nanocar consists of a chassis and axles made of well-defined organic groups with pivoting suspension and freely rotating axles. The wheels are buckyballs, spheres of pure carbon containing 60 atoms apiece. The entire car measures just 3-4 nanometers across, making it slightly wider than a strand of DNA. A human hair, by comparison, is about 80,000 nanometers in diameter.

Automatic Cat Feeder

The Automatic Cat Feeder:

As I dug around this box, I found an old CD Rom drive and power supply. The thought struck me that I could use the ejecting tray of the CD Rom as a solenoid to push the trigger mechanism of some sort of physical contraption. But then I had a bootstrapping problem – what can I use to push the eject button of the CD Rom on schedule?

After some more thought, I realized that I could just use my spare (working) computer as the basis of the cat feeder. It’s also my home’s Subversion source control server – a rare mix of server workloads indeed! It has a CD Rom drive, so I could just use software to open and close it.

And water for the cat too:

Water flows out of the jug as long as the water level is below the hole at the bottom. When water flows out, the air pressure in jug decreases until it sucks in some air to equalize. When the water level covers the hole, though, the air pressure can no longer equalize, so the water flow stops.

When the cats drink the water level down a bit, the jug can once again equalize its air pressure, and lets more water out.

Don’t miss the video – Related: Engineering at Home

Electricity from Bacteria and Wastewater

Researchers harness the power of bacteria by Renee Meiller

In nature, says McMahon, photosynthetic bacteria effectively extract energy from their food — and microbial fuel cells capitalize on that efficiency. “By having the microbes strip the electrons out of the organic waste, and turning that into electricity, then we can make a process of conversion more efficient,” she says. “And they’re very good at doing that-much better than we are with our high-tech extraction methods.”

Through machinery such as plants, photosynthetic bacteria harvest solar energy. They also make products to power microbial fuel cells. “In many ways, this is the best of both worlds — generating electricity from a ‘free’ energy source like sunlight and removing wastes at the same time,” says Donohue. “The trick is to bring ideas from different disciplines to develop biorefineries and fuel cells that take advantage of the capabilities of photosynthetic bacteria.”

The benefit of using photosynthetic bacteria, he says, is that solar-powered microbial fuel cells can generate additional electricity when sunlight is available.