Evolution of Antibiotic Resistance

Posted on February 6, 2006  Comments (3)

Inhibition of Mutation and Combating the Evolution of Antibiotic Resistance from the Public Library of Science Biology Journal:

The emergence of drug-resistant bacteria poses a serious threat to human health. In the case of several antibiotics, including those of the quinolone and rifamycin classes, bacteria rapidly acquire resistance through mutation of chromosomal genes during therapy. In this work, we show that preventing induction of the SOS response by interfering with the activity of the protease LexA renders pathogenic Escherichia coli unable to evolve resistance in vivo to ciprofloxacin or rifampicin, important quinolone and rifamycin antibiotics. We show in vitro that LexA cleavage is induced during RecBC-mediated repair of ciprofloxacin-mediated DNA damage and that this results in the derepression of the SOS-regulated polymerases Pol II, Pol IV and Pol V, which collaborate to induce resistance-conferring mutations. Our findings indicate that the inhibition of mutation could serve as a novel therapeutic strategy to combat the evolution of antibiotic resistance.

3 Responses to “Evolution of Antibiotic Resistance”

  1. Curious Cat Science and Engineering Blog » ‘Virtually untreatable’ TB found
    September 6th, 2006 @ 2:07 pm

    TB presently causes about 1.7 million deaths a year worldwide, but researchers are worried about the emergence of strains that are resistant to drugs…

  2. Curious Cat Science and Engineering Blog » Are Antibiotics Killing Us?
    November 23rd, 2006 @ 4:42 pm

    “To counteract these killers, some physicians have turned to lengthy or lifelong courses of antibiotics. At the same time, other researchers are counterintuitively finding that bacteria we think are bad for us also ward off other diseases and keep us healthy.”…

  3. CuriousCat: I Support the Public Library of Science
    November 3rd, 2007 @ 8:12 pm

    I am a fan of the Public Library of Science, as I have mentioned previous. Yesterday I donated some money to support their great efforts…

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