Generating the molecular worlds described in the screenplay entailed a wide range of challenges in statistical mechanics, molecular modeling, and simulation. To create a truly immersive portal into the nanoscale universe required simulations of a massive scale and complexity – an entirely unusual request for the chemical and biological engineers and scientists involved in the project. The creation of a believable and cinematic molecular landscape to visualize the plot twists and dramatic tension of the story posed a host of new creative challenges for the collaborating scientists. Their involvement in this work has brought about insights that will hopefully spark a breakthrough in the very real worlds of energy, environment, and health.