The Curious Cat Science and Engineering blog explores: innovation, technology, research, education, economics, gadgets, health care and scientific inquiry.
Jeremy Lin’s performance has been amazing. It is always fun to see someone succeed who wasn’t expected to do so well.d Jeremy Lin was waived by two teams and now has lead the Nicks to an amazing performance the last 10 games for the New York Knicks in the NBA. It will be fun to see how it continues.
The video gives a very cursory overview of some of the training Jeremy Lin did between basketball seasons.
A new mouthwash developed by a microbiologist at the UCLA School of Dentistry is highly successful in targeting the harmful Streptococcus mutans bacteria that is the principal cause tooth decay and cavities.
In a recent clinical study, 12 subjects who rinsed just one time with the experimental mouthwash experienced a nearly complete elimination of the S. mutans bacteria over the entire four-day testing period.
Dental caries, commonly known as tooth decay or cavities, is one of the most common and costly infectious diseases in the United States, affecting more than 50 percent of children and the vast majority of adults aged 18 and older. Americans spend more than $70 billion each year on dental services, with the majority of that amount going toward the treatment of dental caries.
This new mouthwash is the product of nearly a decade of research conducted by Wenyuan Shi, chair of the oral biology section at the UCLA School of Dentistry. Shi developed a new antimicrobial technology called STAMP (specifically targeted anti-microbial peptides) with support from Colgate-Palmolive and from C3-Jian Inc., a company he founded around patent rights he developed at UCLA; the patents were exclusively licensed by UCLA to C3-Jian.
The human body is home to millions of different bacteria, some of which cause diseases such as dental caries but many of which are vital for optimum health. Most common broad-spectrum antibiotics, like conventional mouthwash, indiscriminately kill both benign and harmful pathogenic organisms and only do so for a 12-hour time period.
The overuse of broad-spectrum antibiotics can seriously disrupt the body’s normal ecological balance, rendering humans more susceptible to bacterial, yeast and parasitic infections.
Shi’s Sm STAMP C16G2 investigational drug, tested in the clinical study, acts as a sort of “smart bomb,” eliminating only the harmful bacteria and remaining effective for an extended period.
“With this new antimicrobial technology, we have the prospect of actually wiping out tooth decay in our lifetime,” said Shi, who noted that this work may lay the foundation for developing additional target-specific “smart bomb” antimicrobials to combat other diseases.
A disease-fighting protein in our teardrops has been tethered to a tiny transistor, enabling UC Irvine scientists to discover exactly how it destroys dangerous bacteria. The research could prove critical to long-term work aimed at diagnosing cancers and other illnesses in their very early stages.
Ever since Nobel laureate Alexander Fleming found that human tears contain antiseptic proteins called lysozymes about a century ago, scientists have tried to solve the mystery of how they could relentlessly wipe out far larger bacteria. It turns out that lysozymes have jaws that latch on and chomp through rows of cell walls like someone hungrily devouring an ear of corn.
“Those jaws chew apart the walls of the bacteria that are trying to get into your eyes and infect them,” said molecular biologist and chemistry professor Gregory Weiss, who co-led the project with associate professor of physics & astronomy Philip Collins.
The researchers decoded the protein’s behavior by building one of the world’s smallest transistors – 25 times smaller than similar circuitry in laptop computers or smartphones. Individual lysozymes were glued to the live wire, and their eating activities were monitored.
“Our circuits are molecule-sized microphones,” Collins said. “It’s just like a stethoscope listening to your heart, except we’re listening to a single molecule of protein.”
It took years for the UCI scientists to assemble the transistor and attach single-molecule teardrop proteins. The scientists hope the same novel technology can be used to detect cancerous molecules. It could take a decade to figure out but would be well worth it, said Weiss, who lost his father to lung cancer.
“If we can detect single molecules associated with cancer, then that means we’d be able to detect it very, very early,” Weiss said. “That would be very exciting, because we know that if we treat cancer early, it will be much more successful, patients will be cured much faster, and costs will be much less.”
The project was sponsored by the National Cancer Institute and the National Science Foundation. Co-authors of the Science paper are Yongki Choi, Issa Moody, Patrick Sims, Steven Hunt, Brad Corso and Israel Perez.
Silicon Vally investor discusses keys to good investment companies: “Engineers are the new currency… having the right engineers that can innovate and deliver is absolutely vital to success… It takes a great team to help the entrepreneur develop”
The video also makes the point that what separates Silicon Valley is the engineering talent.
the autonomous underwater vehicle (AUV) used a piece of software called “T rex”, which operates in a similar way to the software used to control Nasa’s Mars Exploration Rovers – helping them to avoid obstacles on the surface of the Red Planet.
One main difference between the two pieces of software is that for the Mars rovers, the software ran in the control centre on Earth. With this marine vehicle, it runs onboard the robotic vehicle.
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“We tell it, ‘here’s the range of tasks that we want you to perform’, and it goes off and assesses what is happening in the ocean, making decisions about how much of the range it will cover to get back the data we want.”
Researchers at MBARI used the Gulper AUV to monitor potentially harmful algal blooms.
Kim Fulton-Bennett from MBARI explained: “We used to send out a ship for a full day every few weeks to manually take these measurements. Now we just take the AUV outside the harbour and send it on its way.
“About 24 hours later, it comes back, we hoist it on board, and download the data.”
Great quotes from Oppenheimer’s recommendation of Richard Feynman
“He is by all odds the most brilliant young physicist here, and everyone knows this. He is a man of thoroughly engaging character and personality, extremely clear, extremely normal in all respects, and an excellent teacher with a warm feeling for physics in all its aspects. He has the best possible relations both with the theoretical people of whom he is one, and with the experimental people with whom he works in very close harmony.”
“Bethe has said that he would rather lose any two other men than Feynman from this present job, and Wigner said, ‘He is a second Dirac, only this time human.”
Images of letter from Oppenheimer to the University of California – Berkeley Recommending Richard Feynman for a position, November 4, 1943 (from Big Science at Berkeley).
one ripple effect from the stampede to create more ethanol from corn in the United States. As corn prices skyrocketed several years ago, soybean fields were converted to corn, and the price of soy rose. As a result, farmers in Brazil, one of the main countries with the soil, climate and infrastructure to make up the difference, began to bulldoze rainforest to grow more soybeans.
“If reduced U.S. soybean production results in a parallel increase in Brazilian soybean production, a potential net release of 1,800 to 9,100 Tg (trillion grams) of CO2-equivalents of greenhouse gas emissions due to land-use change is possible,” Coe wrote in a summary of his talk. That is equivalent to more than 9 billion metric tons of carbon dioxide.
Researchers at Caltech, who developed the revolutionary imaging system, say that the devices could be mass-produced at a cost of $10 each and incorporated into large arrays, enabling high-throughput imaging in biology labs. The device could also broaden access to imaging technology: incorporated into PDA-size devices, for example, the microscopes could enable rural doctors to carry sophisticated imaging systems in their pockets.
The Caltech device uses a system of tiny fluid channels called microfluidics to direct cells and even microscopic animals over a light-sensing chip. The chip, an off-the-shelf sensor identical to those found in digital cameras, is covered with a thin layer of metal that blocks out most of the pixels. A few hundred tiny apertures punched in the metal along the fluid channel let light in. As the sample flows through the microscope, each aperture captures an image. One version of the microscope uses gravity to control the flow of the sample across the apertures. Another version, which allows for much better control, uses an electrical potential to drive the flow of cells.
The $100 million in new funds will enable the hiring of additional faculty and support new graduate students, in addition to the more than $30 million in yearly funding now spent on energy research.
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Precourt holds bachelor’s and master’s degrees in petroleum engineering from Stanford and an MBA from Harvard University. He has spent his career in the energy industry, holding president and/or CEO positions at Hamilton Oil Co.; Tejas Gas Corporation, subsequently a Shell Oil Co. subsidiary; and ScissorTail Energy and Hermes Consolidated, gatherers, transporters and processors of natural gas, crude oil and refined products.
He is convinced that Stanford research can influence national energy policy for the better. “The wonderful resources that are available at Stanford, and the multidisciplinary approach they have to developing working solutions, are really attractive in terms of making things happen,” he said.
On a personal level, Precourt said, “Stanford made a huge impact on my life, as I look back on it. It was a superb education and I made some wonderful friends that I’ve taken with me for my lifetime.” Precourt donated $50 million to the energy institute that bears his name.
A $40 million gift from Steyer and Taylor will create a new research center as part of the institute, the TomKat Center for Sustainable Energy.
With today’s announcement, Lokey more than doubles his commitment. School officials say he is the lead contributor for a $200 million stem cell research building that will break ground Oct. 27 and be finished in the summer of 2010. In a statement released by the medical school, Lokey said stem cells would be “as significant as the silicon chip that created Silicon Valley,” producing treatments for disease and saving lives.
He said he was driven to fund research after President Bush, in August 2001, forbid the use of federal funds for stem cell research that involved the destruction of human embryos. “It’s very narrow-minded,” Lokey said of the position. “This is about lives being saved.”
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Some 350 scientists will work in the 200,000-square-foot Lorry I. Lokey Stem Cell Research Building, the school said. The center is also getting a $43.6 million grant from the California Institute for Regenerative Medicine. The institute, the state’s $3 billion stem cell funding unit, was created by a 2004 state initiative from research advocates opposed to Bush’s restrictions.
Paul Rothemund, scientist at Cal Tech, provides a interesting look at DNA folding and DNA based algorithmic self-assembly. In the talk he shows the promise ahead for using biological building blocks using DNA origami — to create tiny machines that assemble themselves from a set of instructions.
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