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	<title>Curious Cat Science and Engineering Blog &#187; Awards</title>
	<atom:link href="http://engineering.curiouscatblog.net/category/awards/feed/" rel="self" type="application/rss+xml" />
	<link>http://engineering.curiouscatblog.net</link>
	<description>Science and Engineering: Innovation, Research, Education and Economics</description>
	<lastBuildDate>Fri, 10 Feb 2012 10:31:54 +0000</lastBuildDate>
	<language>en</language>
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		<title>20th Annual US First Robotics Competition</title>
		<link>http://engineering.curiouscatblog.net/2012/01/08/20th-annual-us-first-robotics-competition/</link>
		<comments>http://engineering.curiouscatblog.net/2012/01/08/20th-annual-us-first-robotics-competition/#comments</comments>
		<pubDate>Mon, 09 Jan 2012 01:20:45 +0000</pubDate>
		<dc:creator>curiouscat</dc:creator>
				<category><![CDATA[Awards]]></category>
		<category><![CDATA[K-12]]></category>
		<category><![CDATA[Robots]]></category>
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		<category><![CDATA[engineering education]]></category>
		<category><![CDATA[Events]]></category>
		<category><![CDATA[FIRST]]></category>
		<category><![CDATA[music]]></category>
		<category><![CDATA[science education]]></category>

		<guid isPermaLink="false">http://engineering.curiouscatblog.net/?p=3926</guid>
		<description><![CDATA[If you have a child, niece, nephew, grandchild&#8230; who you haven&#8217;t been able to convince about the wonders of science maybe the starts on this promo (Justin Timberlake, Snoop Dogg, Justin Bieber&#8230;) can help convince them. If you want to &#8230; <a href="http://engineering.curiouscatblog.net/2012/01/08/20th-annual-us-first-robotics-competition/">Continue reading <span class="meta-nav">&#8594;</span></a>]]></description>
			<content:encoded><![CDATA[<p><iframe width="640" height="360" src="http://www.youtube.com/embed/vYuOKb3gO7E" frameborder="0" allowfullscreen></iframe></p>
<p>If you have a child, niece, nephew, grandchild&#8230; who you haven&#8217;t been able to convince about the wonders of science maybe the starts on this promo (Justin Timberlake, Snoop Dogg, Justin Bieber&#8230;) can help convince them.  If you want to convince your grandparents science is cool, then maybe they will like the cameos by Steven Tyler and Bono <img src='http://engineering.curiouscatblog.net/wp-includes/images/smilies/icon_razz.gif' alt=':-P' class='wp-smiley' />   This is an effort being pushed by will.i.am (Black Eyed Peas) and <a href="http://engineering.curiouscatblog.net/2006/02/23/water-and-electricity-for-all/">Dean Kamen</a> (US First Founder) to promote science and engineering.  Since most politicians don&#8217;t seem interested in promoting and supporting science anymore maybe musicians can help turn things around.</p>
<p>I have <a href="http://engineering.curiouscatblog.net/tag/FIRST/">written about US First</a>, it is a great program.  It <a href="http://engineering.curiouscatblog.net/2010/05/09/teaching-through-tinkering/">engages children in learning by taping their curiosity and desire to create</a>.  I think learning this way is much more natural and fun and affective than what we have too often in schools today.  I know I was bored quite often but was told the adults knew best.  Well know I am an adult and I think I was right back then: our education system can, and should be greatly improved.  Until then, US First, and similar, programs give kids a good environment for learning that keeps their desire to learn intact.</p>
<p>The video spot was created to promote a TV show commemorating the 20th annual <a href="http://www.usfirst.org/">US FIRST Robotics competition</a>.  Watch the TV show:</p>
<p><iframe width="640" height="480" src="http://www.youtube.com/embed/vLMOKM4QKcE" frameborder="0" allowfullscreen></iframe></p>
<p>Related: <a href="http://engineering.curiouscatblog.net/2009/02/02/lunacy-first-robotics-challenge-2009/">Lunacy, FIRST Robotics Challenge 2009</a> &#8211; <a href="http://engineering.curiouscatblog.net/2005/12/07/for-inspiration-and-recognition-of-science-and-technology-first/">For Inspiration and Recognition of Science and Technology (FIRST), 2005 post</a> &#8211; <a href="http://engineering.curiouscatblog.net/2009/10/02/test-it-out-experiment-by-they-might-be-giants/">Test it Out, Experiment by They Might Be Giants</a> &#8211; <a href="http://engineering.curiouscatblog.net/2009/07/08/botball-2009-finals/">Botball 2009 Finals</a></p>
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		<title>YouTube SpaceLab Experiment Competition</title>
		<link>http://engineering.curiouscatblog.net/2011/11/24/youtube-spacelab-experiment-competition/</link>
		<comments>http://engineering.curiouscatblog.net/2011/11/24/youtube-spacelab-experiment-competition/#comments</comments>
		<pubDate>Thu, 24 Nov 2011 10:01:16 +0000</pubDate>
		<dc:creator>curiouscat</dc:creator>
				<category><![CDATA[Awards]]></category>
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		<guid isPermaLink="false">http://engineering.curiouscatblog.net/?p=3850</guid>
		<description><![CDATA[YouTube SpaceLab is an open competition inviting 14 &#8211; 18 year olds (anywhere in the world) to create an idea for a science experiment in space. You don&#8217;t have to actually do the experiment, you just have to record yourself &#8230; <a href="http://engineering.curiouscatblog.net/2011/11/24/youtube-spacelab-experiment-competition/">Continue reading <span class="meta-nav">&#8594;</span></a>]]></description>
			<content:encoded><![CDATA[<p>YouTube SpaceLab is an open competition inviting 14 &#8211; 18 year olds (anywhere in the world) to create an idea for a science experiment in space. You don&#8217;t have to actually do the experiment, you just have to <a href="https://www.youtube.com/spacelab?x=how-to-enter">record yourself explaining it</a>.</p>
<p>Entries must have be submitted on YouTube by 07:59 GMT on December 8th.</p>
<p>The winning experiments will be conducted on the International Space Station (ISS) and beamed live on YouTube for the whole planet to see.</p>
<p>Winners get the choice to either watch the rocket blast off with your idea on it in Japan or take a specially tailored astronaut training course in Russia when you turn 18. There are other amazing prizes for the runners-up too.</p>
<p>Here is an example entry from 3 students in UK on an experiment to learn about quorum sensing by bacteria in the micro gravity of space.</p>
<p><iframe width="640" height="360" src="http://www.youtube.com/embed/Dzn_Kr7mgyc" frameborder="0" allowfullscreen></iframe></p>
<p>Related: <a href="http://engineering.curiouscatblog.net/2011/05/10/google-science-fair-2011-projects/">Google Science Fair 2011 Projects</a> &#8211; <a href="http://engineering.curiouscatblog.net/2009/04/10/bacteria-communicate-using-a-chemical-language/">Bacteria Communicate Using a Chemical Language (quorum sensing)</a> &#8211; <a href="http://engineering.curiouscatblog.net/2011/03/23/11-year-old-using-design-of-experiments/">11 Year Old Using Design of Experiments</a> &#8211; <a href="http://engineering.curiouscatblog.net/2010/12/24/8-10-year-olds-research-published-in-royal-socity-journal/">Research by group of 8 to 10 Year Olds Published in Royal Society Journal</a></p>
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		<title>2011 Nobel Prize in Chemistry</title>
		<link>http://engineering.curiouscatblog.net/2011/10/09/2011-nobel-prize-in-chemistry/</link>
		<comments>http://engineering.curiouscatblog.net/2011/10/09/2011-nobel-prize-in-chemistry/#comments</comments>
		<pubDate>Sun, 09 Oct 2011 05:54:55 +0000</pubDate>
		<dc:creator>curiouscat</dc:creator>
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		<guid isPermaLink="false">http://engineering.curiouscatblog.net/?p=3783</guid>
		<description><![CDATA[The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry for 2011 to Dan Shechtman, Technion &#8211; Israel Institute of Technology, Haifa, Israel for the discovery of quasicrystals. In quasicrystals, we find the fascinating mosaics &#8230; <a href="http://engineering.curiouscatblog.net/2011/10/09/2011-nobel-prize-in-chemistry/">Continue reading <span class="meta-nav">&#8594;</span></a>]]></description>
			<content:encoded><![CDATA[<div id="attachment_3784" class="wp-caption alignleft" style="width: 290px"><img src="http://engineering.curiouscatblog.net/wp-content/uploads/2011/10/dan_shechtman.jpg" alt="photo of Dan Shechtman" title="Dan Shechtman" width="280" height="396" class="size-full wp-image-3784" /><p class="wp-caption-text">Dan Shechtman, Israel Institute of Technology, 2011 Nobel Laurette in Chemistry</p></div>
<p>The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry for 2011 to Dan Shechtman,  Technion &#8211; Israel Institute of Technology, Haifa, Israel for the discovery of quasicrystals.</p>
<p>In quasicrystals, we find the fascinating mosaics reproduced at the level of atoms: regular patterns that never repeat themselves. However, the configuration found in quasicrystals was considered impossible, and Dan Shechtman had to <a href="http://engineering.curiouscatblog.net/2011/04/18/gravity-and-the-scientific-method/">fight a fierce battle against established science</a>. The Nobel Prize in Chemistry 2011 has fundamentally altered how chemists conceive of solid matter.</p>
<p>On the morning of 8 April 1982, an image counter to the laws of nature appeared in Dan Shechtman&#8217;s electron microscope. In all solid matter, atoms were believed to be packed inside crystals in symmetrical patterns that were repeated periodically over and over again. For scientists, this repetition was required in order to obtain a crystal.</p>
<p>Shechtman&#8217;s image, however, showed that the atoms in his crystal were packed in a pattern that could not be repeated. Such a pattern was considered just as impossible as creating a football using only six-cornered polygons, when a sphere needs both five- and six-cornered polygons. His discovery was extremely controversial. In the course of defending his findings, he was asked to leave his research group. However, his battle eventually forced scientists to reconsider their conception of the very nature of matter.</p>
<p>Aperiodic mosaics, such as those found in the medieval Islamic mosaics of the Alhambra Palace in Spain and the Darb-i Imam Shrine in Iran, have helped scientists understand what quasicrystals look like at the atomic level. In those mosaics, as in quasicrystals, the patterns are regular &#8211; they follow mathematical rules &#8211; but they never repeat themselves.</p>
<p>When scientists describe Shechtman&#8217;s quasicrystals, they use a concept that comes from mathematics and art: the golden ratio. This number had already caught the interest of mathematicians in Ancient Greece, as it often appeared in geometry. In quasicrystals, for instance, the ratio of various distances between atoms is related to the golden mean.</p>
<p>Following Shechtman&#8217;s discovery, scientists have produced other kinds of quasicrystals in the lab and discovered naturally occurring quasicrystals in mineral samples from a Russian river. A Swedish company has also found quasicrystals in a certain form of steel, where the crystals reinforce the material like armor. Scientists are currently experimenting with using quasicrystals in different products such as frying pans and diesel engines.</p>
<p>Related: <a href="http://engineering.curiouscatblog.net/2009/10/07/2009-nobel-prize-in-chemistry-the-structure-and-function-of-the-ribosome/">2009 Nobel Prize in Chemistry: the Structure and Function of the Ribosome</a> &#8211; <a href="http://engineering.curiouscatblog.net/2008/10/08/the-nobel-prize-in-chemistry-2008/">The Nobel Prize in Chemistry 2008</a> &#8211; <a href="http://engineering.curiouscatblog.net/2006/10/04/nobel-prize-in-chemistry-2006/">Nobel Prize in Chemistry (2006)</a></p>
<p><a href="http://www.nobelprize.org/nobel_prizes/chemistry/laureates/2011/info_publ_eng_2011.pdf">Read more on the science</a> he has worked on.  Our understanding of science is built on the discoveries of our predecessors and on the discoveries that counter what we thought we knew.<br />
<span id="more-3783"></span></p>
<div class="cite">However, with fivefold symmetry (figure 3d), this is not possible, as distances between certain atoms will be shorter than between others. The pattern does not repeat itself, which was proof enough to scientists that it  was not possible to obtain fivefold symmetries in crystals. The same applies to sevenfold or higher symmetries.</p>
<p>Shechtman, however, could rotate his diffraction pattern by a tenth of a full circle (36 degrees) and still  obtain the same pattern. Hence he was looking at a tenfold symmetry, one that was considered impossible.  It is no surprise, then, that he made no less than three question marks in his notebook.<br />
&#8230;<br />
Dan Shechtman peeked out from his office into the corridor at the U.S. National Institute of Standards and Technology (NIST), wanting to find someone with whom he could share his discovery. But the corridor was empty, so he went back to the microscope to carry out further experiments on the peculiar crystal. Among other things,  he double-checked if he had obtained a twin crystal: two intergrown crystals whose shared boundary gives rise to  strange diffraction patterns. But he could not detect any signs that he was in fact looking at a twin crystal.<br />
&#8230;<br />
Dan Shechtman concluded that the scientific community must be mistaken in its assumptions.  When Shechtman told scientists about his discovery, he was faced with complete opposition, and some colleagues even resorted to ridicule. Many claimed that what he had observed was in fact a twin crystal. The  head of the laboratory gave him a textbook of crystallography and suggested he should read it. </p>
<p>Shechtman, of course, already knew what it said but trusted his experiments more than the textbook. All the commotion finally led his boss to ask him to leave the research group, as Schechtman himself recalled later. The situation had become too embarrassing.</p></div>
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		<title>2011 Nobel Prize in Physics</title>
		<link>http://engineering.curiouscatblog.net/2011/10/04/2011-nobel-prize-in-physics/</link>
		<comments>http://engineering.curiouscatblog.net/2011/10/04/2011-nobel-prize-in-physics/#comments</comments>
		<pubDate>Wed, 05 Oct 2011 03:06:22 +0000</pubDate>
		<dc:creator>curiouscat</dc:creator>
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		<guid isPermaLink="false">http://engineering.curiouscatblog.net/?p=3779</guid>
		<description><![CDATA[The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Physics for 2011 with one half to Saul Perlmutter The Supernova Cosmology Project, Lawrence Berkeley National Laboratory and University of California, Berkeley, CA, USA and the &#8230; <a href="http://engineering.curiouscatblog.net/2011/10/04/2011-nobel-prize-in-physics/">Continue reading <span class="meta-nav">&#8594;</span></a>]]></description>
			<content:encoded><![CDATA[<div id="attachment_3780" class="wp-caption alignleft" style="width: 536px"><img src="http://engineering.curiouscatblog.net/wp-content/uploads/2011/10/physics_nobel_2011.png" alt="Photos of the 2011 Physics Nobel Prize Winners: Saul Perlmutter, Brian Schmidt and Adam Riess." title="Photos of the 2011 Physics Nobel Prize Winners: Saul Perlmutter, Brian Schmidt and Adam Riess." width="526" height="279" class="size-full wp-image-3780" /><p class="wp-caption-text">Photos of the 2011 Physics Nobel Prize Winners.</p></div>
<p>The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Physics for 2011  with one half to</p>
<p>Saul Perlmutter<br />
The Supernova Cosmology Project, Lawrence Berkeley National Laboratory and University of California, Berkeley, CA, USA</p>
<p>and the other half jointly to</p>
<p>Brian P. Schmidt<br />
The High-z Supernova Search Team, Australian National University, Weston Creek, Australia</p>
<p>and</p>
<p>Adam G. Riess<br />
The High-z Supernova Search Team, Johns Hopkins University and Space Telescope Science Institute,  Baltimore, MD, USA</p>
<p>&#8220;for the discovery of the accelerating expansion of the Universe through observations of distant supernovae&#8221;</p>
<p>Once again the USA dominates the physics category, Brian Schmidt is a USA and Australian citizen.  It will be interesting to see if this starts to change in the next decade.  I believe it will at some point fairly soon, the question is at what point.</p>
<p>&#8220;Some say the world will end in fire, some say in ice&#8230;&#8221; <a href="http://www.amazon.com/exec/obidos/ISBN= 188301106x/worldwidedemingw">Robert Frost</a>, Fire and Ice, 1920</p>
<p>What will be the final destiny of the Universe? Probably it will end in ice, if we are to believe this year&#8217;s Nobel Laureates in Physics. They have studied several dozen exploding stars, called supernovae, and discovered that the Universe is expanding at an ever-accelerating rate. The discovery came as a complete surprise even to the Laureates themselves.</p>
<p>In 1998, cosmology was shaken at its foundations as two research teams presented their findings. Headed by Saul Perlmutter, one of the teams had set to work in 1988. Brian Schmidt headed another team, launched at the end of 1994, where Adam Riess was to play a crucial role.</p>
<p>The research teams raced to map the Universe by locating the most distant supernovae. More sophisticated telescopes on the ground and in space, as well as more powerful computers and new digital imaging sensors (CCD, Nobel Prize in Physics in 2009), opened the possibility in the 1990s to add more pieces to the cosmological puzzle.</p>
<p>The teams used a particular kind of supernova, called type Ia supernova. It is an explosion of an old compact star that is as heavy as the Sun but as small as the Earth. A single such supernova can emit as much light as a whole galaxy. All in all, the two research teams found over 50 distant supernovae whose light was weaker than expected &#8211; this was a sign that the expansion of the Universe was accelerating. The potential pitfalls had been numerous, and the scientists found reassurance in the fact that both groups had reached the same astonishing conclusion.</p>
<p>For almost a century, the Universe has been known to be expanding as a consequence of the Big Bang about 14 billion years ago. However, the discovery that this expansion is accelerating is astounding. If the expansion will continue to speed up the Universe will end in ice.</p>
<p>The acceleration is thought to be driven by dark energy, but what that dark energy is remains an enigma &#8211; perhaps the greatest in physics today. What is known is that dark energy constitutes about three quarters of the Universe. Therefore the findings of the 2011 Nobel Laureates in Physics have helped to unveil a Universe that to a large extent is unknown to science. And everything is possible again.</p>
<p>As usually the Nobel committee does a great job of providing the <a href="http://www.nobelprize.org/nobel_prizes/physics/laureates/2011/info_publ_phy_11_en.pdf">public open scientific information</a>.  Others that claim to promote science can learn from them.  They do a great job of making the science understandable to a lay person.</p>
<div class="cite">The discovery came as a complete surprise even to the Nobel Laureates themselves. What they saw would be like throwing a ball up in the air, and instead of having it come back down, watching as it disappears more and more rapidly into the sky, as if gravity could not manage to reverse the ball’s trajectory. Something similar seemed to be happening across the entire Universe.</p>
<p>The growing rate of the expansion implies that the Universe is being pushed apart by an unknown form of energy embedded in the fabric of space. This dark energy makes up a large part of the Universe, more than 70 %, and it is an enigma, perhaps the greatest in physics today. No wonder, then, that cosmology was shaken  at its foundations when two different research groups presented similar results in 1998.<br />
&#8230;</p></div>
<p>Related: <a href="http://engineering.curiouscatblog.net/2009/10/08/the-nobel-prize-in-physics-2009/">The Nobel Prize in Physics 2009</a> &#8211; <a href="http://engineering.curiouscatblog.net/2006/10/03/2006-nobel-prize-in-physics/">2006 Nobel Prize in Physics</a> &#8211; <a href="http://engineering.curiouscatblog.net/2011/10/03/2011-nobel-prize-in-physiology-or-medicine/">2011 Nobel Prize in Physiology or Medicine</a> &#8211; <a href="http://engineering.curiouscatblog.net/2011/09/02/is-dark-matter-an-illusion/">Is Dark Matter an Illusion?</a> &#8211; <a href="http://engineering.curiouscatblog.net/2011/04/29/5-of-the-universe-is-normal-matter-what-about-the-other-95/">5% of the Universe is Normal Matter, What About the Other 95%?</a><br />
<span id="more-3779"></span><br />
<a href="http://www.physics.berkeley.edu/research/faculty/perlmutter.html">Saul Perlmutter</a>, U.S. citizen. Born 1959 in Champaign-Urbana, IL, USA. Ph.D. 1986 from University of California, Berkeley, USA. Head of the Supernova Cosmology Project, Professor of Astrophysics, Lawrence Berkeley National Laboratory and University of California, Berkeley, CA, USA.</p>
<p><a href="http://msowww.anu.edu.au/~brian/">Brian P. Schmidt</a>, U.S. and Australian citizen. Born 1967 in Missoula, MT, USA. Ph.D. 1993 from Harvard University, Cambridge, MA, USA. Head of the High-z Supernova Search Team, Distinguished Professor, Australian National University, Weston Creek, Australia.</p>
<p><a href="http://www.stsci.edu/~ariess/">Adam G. Riess</a>, U.S. citizen. Born 1969 in Washington, DC, USA. Ph.D. 1996 from Harvard University, Cambridge, MA, USA. Professor of Astronomy and Physics, Johns Hopkins University and Space Telescope Science Institute, Baltimore, MD, USA.</p>
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		<title>2011 Nobel Prize in Physiology or Medicine</title>
		<link>http://engineering.curiouscatblog.net/2011/10/03/2011-nobel-prize-in-physiology-or-medicine/</link>
		<comments>http://engineering.curiouscatblog.net/2011/10/03/2011-nobel-prize-in-physiology-or-medicine/#comments</comments>
		<pubDate>Tue, 04 Oct 2011 01:17:22 +0000</pubDate>
		<dc:creator>curiouscat</dc:creator>
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		<description><![CDATA[The Nobel Assembly at Karolinska Institutet has today decided that The Nobel Prize in Physiology or Medicine 2011 shall be divided, with one half jointly to Bruce A. Beutler and Jules A. Hoffmann for their discoveries concerning the activation of &#8230; <a href="http://engineering.curiouscatblog.net/2011/10/03/2011-nobel-prize-in-physiology-or-medicine/">Continue reading <span class="meta-nav">&#8594;</span></a>]]></description>
			<content:encoded><![CDATA[<p>The Nobel Assembly at Karolinska Institutet has today decided that The Nobel Prize in Physiology or Medicine 2011 shall be divided, with one half jointly to Bruce A. Beutler and Jules A. Hoffmann for their discoveries concerning the activation of innate immunity and the other half to Ralph M. Steinman for his discovery of the dendritic cell and its role in adaptive immunity.</p>
<p>This year&#8217;s Nobel Laureates have revolutionized our understanding of the immune system by discovering key principles for its activation.</p>
<p>Scientists have long been searching for the gatekeepers of the immune response by which man and other animals defend themselves against attack by bacteria and other microorganisms. Bruce Beutler and Jules Hoffmann discovered receptor proteins that can recognize such microorganisms and activate innate immunity, the first step in the body&#8217;s immune response. Ralph Steinman discovered the dendritic cells of the immune system and their unique capacity to activate and regulate adaptive immunity, the later stage of the immune response during which microorganisms are cleared from the body.</p>
<p>The discoveries of the three Nobel Laureates have revealed how the innate and adaptive phases of the immune response are activated and thereby provided novel insights into disease mechanisms. Their work has opened up new avenues for the development of prevention and therapy against infections, cancer, and inflammatory diseases.</p>
<p>We live in a dangerous world. Pathogenic microorganisms (bacteria, virus, fungi, and parasites) threaten us continuously but we are equipped with powerful defense mechanisms (please see image below). The first line of defense, innate immunity, can destroy invading microorganisms and trigger inflammation that contributes to blocking their assault. If microorganisms break through this defense line, adaptive immunity is called into action. With its T and B cells, it produces antibodies and killer cells that destroy infected cells. After successfully combating the infectious assault, our adaptive immune system maintains an immunologic memory that allows a more rapid and powerful mobilization of defense forces next time the same microorganism attacks. These two defense lines of the immune system provide good protection against infections but they also pose a risk. If the activation threshold is too low, or if endogenous molecules can activate the system, inflammatory disease may follow.</p>
<p>The components of the immune system have been identified step by step during the 20th century. Thanks to a series of discoveries awarded the Nobel Prize, we know, for instance, how antibodies are constructed and how T cells recognize foreign substances. However, until the work of Beutler, Hoffmann and Steinman, the mechanisms triggering the activation of innate immunity and mediating the communication between innate and adaptive immunity remained enigmatic.</p>
<p>Related: <a href="http://engineering.curiouscatblog.net/2009/10/05/2009-nobel-prize-in-physiology-or-medicine/">2009 Nobel Prize in Physiology or Medicine</a> &#8211; <a href="http://engineering.curiouscatblog.net/2008/10/06/nobel-prize-in-physiology-or-medicine-2008/">Nobel Prize in Physiology or Medicine 2008</a> &#8211; <a href="http://engineering.curiouscatblog.net/2009/10/07/2009-nobel-prize-in-chemistry-the-structure-and-function-of-the-ribosome/">2009 Nobel Prize in Chemistry: the Structure and Function of the Ribosome</a></p>
<div id="attachment_3776" class="wp-caption alignleft" style="width: 525px"><img src="http://engineering.curiouscatblog.net/wp-content/uploads/2011/10/ralph_steinman.jpg" alt="photo of Ralph Steinman" title="Ralph Steinman" width="515" height="300" class="size-full wp-image-3776" /><p class="wp-caption-text">Ralph Steinman was awarded the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity.  He was born in Canada and was a professor at Rockefeller University at the end of his career.</p></div>
<p><span id="more-3775"></span><br />
Ralph Steinman discovered, in 1973, a new cell type that he called the dendritic cell. He speculated that it could be important in the immune system and went on to test whether dendritic cells could activate T cells, a cell type that has a key role in adaptive immunity and develops an immunologic memory against many different substances. In cell culture experiments, he showed that the presence of dendritic cells resulted in vivid responses of T cells to such substances. These findings were initially met with skepticism but subsequent work by Steinman demonstrated that dendritic cells have a unique capacity to activate T cells.</p>
<p>Further studies by Steinman and other scientists went on to address the question of how the adaptive immune system decides whether or not it should be activated when encountering various substances. Signals arising from the innate immune response and sensed by dendritic cells were shown to control T cell activation. This makes it possible for the immune system to react towards pathogenic microorganisms while avoiding an attack on the body&#8217;s own endogenous molecules.</p>
<p>Jules Hoffmann made his pioneering discovery in 1996, when he and his co-workers investigated how fruit flies combat infections. They had access to flies with mutations in several different genes including Toll, a gene previously found to be involved in embryonal development by Christiane Nüsslein-Volhard (Nobel Prize 1995). When Hoffmann infected his fruit flies with bacteria or fungi, he discovered that Toll mutants died because they could not mount an effective defense. He was also able to conclude that the product of the Toll gene was involved in sensing pathogenic microorganisms and Toll activation was needed for successful defense against them.</p>
<p>Bruce Beutler was searching for a receptor that could bind the bacterial product, lipopolysaccharide (LPS), which can cause septic shock, a life threatening condition that involves overstimulation of the immune system. In 1998, Beutler and his colleagues discovered that mice resistant to LPS had a mutation in a gene that was quite similar to the Toll gene of the fruit fly. This Toll-like receptor (TLR) turned out to be the elusive LPS receptor. When it binds LPS, signals are activated that cause inflammation and, when LPS doses are excessive, septic shock. These findings showed that mammals and fruit flies use similar molecules to activate innate immunity when encountering pathogenic microorganisms. The sensors of innate immunity had finally been discovered.</p>
<p>The discoveries of Hoffmann and Beutler triggered an explosion of research in innate immunity. Around a dozen different TLRs have now been identified in humans and mice. Each one of them recognizes certain types of molecules common in microorganisms. Individuals with certain mutations in these receptors carry an increased risk of infections while other genetic variants of TLR are associated with an increased risk for chronic inflammatory diseases.</p>
<p>The discoveries that are awarded the 2011 Nobel Prize have provided novel insights into the activation and regulation of our immune system. They have made possible the development of new methods for preventing and treating disease, for instance with improved vaccines against infections and in attempts to stimulate the immune system to attack tumors. These discoveries also help us understand why the immune system can attack our own tissues, thus providing clues for novel treatment of inflammatory diseases.</p>
<p><a href="http://www.nobelprize.org/nobel_prizes/medicine/laureates/2011/beutler-interview.html">Bruce A. Beutler</a> was born in 1957 in Chicago, USA. He received his MD from the University of Chicago in 1981 and worked as a scientist at Rockefeller University in New York and the University of Texas in Dallas, where he discovered the LPS receptor. Since 2000 he has been professor of genetics and immunology at The Scripps Research Institute, La Jolla, USA.</p>
<p><a href="http://www.nobelprize.org/nobel_prizes/medicine/laureates/2011/hoffmann.html">Jules A. Hoffmann</a> was born in Echternach, Luxembourg in 1941. He studied at the University of Strasbourg in France, where he obtained his PhD in 1969. After postdoctoral training at the University of Marburg, Germany, he returned to Strasbourg, where he headed a research laboratory from 1974 to 2009. He has also served as director of the Institute for Molecular Cell Biology in Strasbourg and during 2007-2008 as President of the French National Academy of Sciences.</p>
<p><a href="http://newswire.rockefeller.edu/?page=engine&#038;id=1192">Ralph M. Steinman</a> was born in 1943 in Montreal, Canada, where he studied biology and chemistry at McGill University. After studying medicine at Harvard Medical School in Boston, MA, USA, he received his MD in 1968. He has been affiliated with Rockefeller University in New York since 1970, has been professor of immunology at this institution since 1988, and is also director of its Center for Immunology and Immune Diseases.  He died several days before the announcement.  Nobel Prizes are not given posthumously.  The Nobel committee decided <a href="http://www.nobelprize.org/press/nobelfoundation/press_releases/2011/steinman.html">he should retain his prize</a>, wisely in my opinion.</p>
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		<title>Great Projects From First Google Science Fair Finalists</title>
		<link>http://engineering.curiouscatblog.net/2011/07/20/great-projects-from-first-google-science-fair-finalists/</link>
		<comments>http://engineering.curiouscatblog.net/2011/07/20/great-projects-from-first-google-science-fair-finalists/#comments</comments>
		<pubDate>Thu, 21 Jul 2011 00:54:18 +0000</pubDate>
		<dc:creator>curiouscat</dc:creator>
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		<description><![CDATA[15 finalists (from 3 different age groups &#8211; 13-14 years old, 15-16 and 17-18) were selected. 11 finalists were from the USA and 1 each from Singapore, Canada, India and South Africa. These examples of what can be done with &#8230; <a href="http://engineering.curiouscatblog.net/2011/07/20/great-projects-from-first-google-science-fair-finalists/">Continue reading <span class="meta-nav">&#8594;</span></a>]]></description>
			<content:encoded><![CDATA[<p>15 finalists (from 3 different age groups &#8211; 13-14 years old, 15-16 and 17-18) were selected.  11 finalists were from the USA and 1 each from Singapore, Canada, India and South Africa.  These examples of what can be done with imagination, effort and a scientific mindset is great.</p>
<p><iframe width="560" height="349" src="http://www.youtube.com/embed/4TlrA2TLqno" frameborder="0" allowfullscreen></iframe></p>
<p>The grand prize winner, Shree Boseer&#8217;s project:</p>
<div class="cite">Each year, over 21,000 women are diagnosed with ovariancancer – the 5th leading cause of cancer-related deaths in women in the United States. One of the most common drugs usedin ovarian cancer chemotherapy is cisplatin, a platinum-based chemotherapy treatment. While the drug affects ordinary cells, the significantly higher replication frequency of cancer cells causes cisplatin to have a greater impact in malignant cells. However, cancer cells often develop resistance to cisplatin, rendering the treatment ineffective. To improve the efficiency of cisplatin treatment, this research sought to determine whether AMP kinase, an energy protein of cell, plays a role in the development of cisplatin resistance. Studies with various techniques showed a significant difference on cell death caused by cisplatin insensitive and resistant ovarian cancer cells when AMPK was inhibited,suggesting that AMPK plays a role in the development of resistance. This work,in addition to offering a new treatment regime, also furthers our understanding of ovarian cancer and cancers in general.</div>
<p>This is a great project and the experience for the students is wonderful. Still I do think the prizes should be much larger given all the large corporations involved.  Get involved with the next <a href="http://www.google.com/events/sciencefair/">Google Science fair</a>.</p>
<p><a href="http://engineering.curiouscatblog.net/2011/05/10/google-science-fair-2011-projects/">Google Science Fair 2011 Projects semi finalists</a> &#8211; <a href="http://engineering.curiouscatblog.net/2009/05/17/intel-science-and-engineering-fair-2009-webcasts/">Intel Science and Engineering Fair 2009 Webcasts</a> &#8211; <a href="http://googleblog.blogspot.com/2011/07/hats-off-to-winners-of-inaugural-google.html">Hats off to the winners of the inaugural Google Science Fair</a> &#8211; <a href="http://engineering.curiouscatblog.net/2009/11/23/president-obama-speaks-on-getting-students-excited-about-science-and-engineering/">President Obama Speaks on Getting Students Excited About Science and Engineering</a><br />
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<p><iframe width="560" height="349" src="http://www.youtube.com/embed/luffXvfC_A4" frameborder="0" allowfullscreen></iframe></p>
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		<title>Google Science Fair 2011 Projects</title>
		<link>http://engineering.curiouscatblog.net/2011/05/10/google-science-fair-2011-projects/</link>
		<comments>http://engineering.curiouscatblog.net/2011/05/10/google-science-fair-2011-projects/#comments</comments>
		<pubDate>Wed, 11 May 2011 01:46:25 +0000</pubDate>
		<dc:creator>curiouscat</dc:creator>
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		<guid isPermaLink="false">http://engineering.curiouscatblog.net/?p=3593</guid>
		<description><![CDATA[The Google Science Fair selected 60 semi-finalists in 3 groups (age 13-14, 15-16 and 17-18). The 60 global semi finalists will then be narrowed down by our judging panel to 15 global finalists who will be announced later in May. &#8230; <a href="http://engineering.curiouscatblog.net/2011/05/10/google-science-fair-2011-projects/">Continue reading <span class="meta-nav">&#8594;</span></a>]]></description>
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<p>The <a href="http://www.google.com/events/sciencefair/">Google Science Fair</a> selected 60 semi-finalists in 3 groups (age 13-14, 15-16 and 17-18).  The 60 global semi finalists will then be narrowed down by our judging panel to 15 global finalists who will be announced later in May.</p>
<p>The 15 global finalists will be flown to Google HQ in California, USA for our celebratory Science Fair event and finalist judging round will take place on 11 July 2011. These finalists will be expected to present their projects before a panel of acclaimed scientists including Nobel Laureates, tech visionaries and household names.</p>
<p>Sailboats using canting keels are among the world’s fastest ocean-going vessels; however, there are inherent problems. Canting sailboats require the addition of canards or dagger boards to replace the loss of the primary underwater lifting surface, adding significant complexity. The second and more important issue is that the cantilevered weight of the ballast bulb at the end of the keel generates tremendous loads on the vessel. The objective of this research was to test a concept to make sailboats even faster and safer than the current designs. To test the concept, this researcher built a remote control functional model fitted for both canting and hydrodynamic keels. The results showed that the <a href="http://www.google.com/events/sciencefair/projects/the_winged_keel.html">hydrodynamic keel</a> out performs the canting keel both upwind and downwind.</p>
<p>The Grand Prize winner plus one parent or guardian per winner will win an amazing 10 day trip to the Galapagos Islands with National Geographic Expeditions. Traveling aboard the National Geographic Endeavour the winner will visit Darwin&#8217;s living laboratory and experience up-close encounters with unique species such as flightless cormorants, marine iguanas, and domed giant tortoises.  They also win a $50,000 scholarship, split equally between team members should a team win this prize. This scholarship is intended to be used towards the finalists’ further education.</p>
<p>The 2 age group winners that are not selected as the grand prize winner will win $25,000 scholarships.</p>
<p><a href="http://www.google.com/events/sciencefair/vote.html">You can vote</a> on your favorite projects and help select the people&#8217;s choice winner that will receive a $10,000 scholarship.</p>
<p>Related: <a href="http://engineering.curiouscatblog.net/2011/03/23/11-year-old-using-design-of-experiments/">11 Year Old Using Design of Experiments</a> &#8211; <a href="http://engineering.curiouscatblog.net/2009/11/23/president-obama-speaks-on-getting-students-excited-about-science-and-engineering/">President Obama Speaks on Getting Students Excited About Science and Engineering</a> &#8211; <a href="http://engineering.curiouscatblog.net/2006/10/13/science-fair-project-on-bacterial-growth-on-packaged-salads/">Science Fair Project on Bacterial Growth on Packaged Salads</a></p>
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		<title>University of Wisconsin-Stout Wins 2010 Rube Goldberg Contest</title>
		<link>http://engineering.curiouscatblog.net/2010/04/03/university-of-wisconsin-stout-wins-2010-rube-goldberg-contest/</link>
		<comments>http://engineering.curiouscatblog.net/2010/04/03/university-of-wisconsin-stout-wins-2010-rube-goldberg-contest/#comments</comments>
		<pubDate>Sat, 03 Apr 2010 20:51:35 +0000</pubDate>
		<dc:creator>curiouscat</dc:creator>
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		<description><![CDATA[University of Wisconsin-Stout wins 2010 Rube Goldberg contest The team&#8217;s machine was called &#8220;Valley of the Kings&#8221; and had an Egyptian theme, telling a tale of events following the death of King Tut. The task for the Rube Goldberg machines &#8230; <a href="http://engineering.curiouscatblog.net/2010/04/03/university-of-wisconsin-stout-wins-2010-rube-goldberg-contest/">Continue reading <span class="meta-nav">&#8594;</span></a>]]></description>
			<content:encoded><![CDATA[<p><object width="480" height="385"><param name="movie" value="http://www.youtube.com/v/0TW6beIYKT4&#038;hl=en_US&#038;fs=1&#038;color1=0x2b405b&#038;color2=0x6b8ab6"></param><param name="allowFullScreen" value="true"></param><param name="allowscriptaccess" value="always"></param><embed src="http://www.youtube.com/v/0TW6beIYKT4&#038;hl=en_US&#038;fs=1&#038;color1=0x2b405b&#038;color2=0x6b8ab6" type="application/x-shockwave-flash" allowscriptaccess="always" allowfullscreen="true" width="480" height="385"></embed></object></p>
<p><a href="http://www.purdue.edu/newsroom/events/2010/100327KlaukeRubeNational.html">University of Wisconsin-Stout wins 2010 Rube Goldberg contest</a></p>
<div class="cite">The team&#8217;s machine was called &#8220;Valley of the Kings&#8221; and had an Egyptian theme, telling a tale of events following the death of King Tut.</p>
<p>The task for the Rube Goldberg machines this year was to dispense sanitizer into a hand. Wisconsin-Stout&#8217;s machine dispensed the sanitizer into a mummy&#8217;s hand.  The <a href="http://www.rubemachine.com/">Rube Goldberg competition</a>, sponsored by Phi Chapter of Theta Tau fraternity, rewards machines that most effectively combine creativity with inefficiency and complexity.</p>
<p>Machines must use at least 20 steps to complete the task in no more than two minutes. Teams have three tries to complete two runs. Points are deducted if students have to assist the machine once it has started.  The Wisconsin-Stout machine has 120 steps. The team completed two perfect runs with no interventions in about a minute and a half each.<br />
&#8230;<br />
St. Olaf&#8217; College of Northfield, Minn., last year&#8217;s national winner, took second place with a medieval-themed machine. Pennsylvania State University placed third with an &#8220;Indiana Jones&#8221; theme.</p></div>
<p>Related: <a href="http://engineering.curiouscatblog.net/2005/11/02/rube-goldberg-machine-contest/">Rube Goldberg Machine Contest (2005)</a> &#8211; <a href="http://engineering.curiouscatblog.net/2008/09/20/goldbergian-flash-fits-rube-goldberg-web-site/">Goldbergian Flash Fits Rube Goldberg Web Site</a> &#8211; <a href="http://engineering.curiouscatblog.net/2009/07/08/botball-2009-finals/">Botball 2009 Finals</a> &#8211; <a href="http://engineering.curiouscatblog.net/2006/09/16/uw-madison-wins-4th-concrete-canoe-competition/">UW- Madison Wins 4th Concrete Canoe Competition</a></p>
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		<title>$100,000 Lemelson-MIT Award for Sustainability</title>
		<link>http://engineering.curiouscatblog.net/2010/02/10/100000-lemelson-mit-award-for-sustainability/</link>
		<comments>http://engineering.curiouscatblog.net/2010/02/10/100000-lemelson-mit-award-for-sustainability/#comments</comments>
		<pubDate>Wed, 10 Feb 2010 18:15:53 +0000</pubDate>
		<dc:creator>curiouscat</dc:creator>
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		<description><![CDATA[According to the United Nations, more than 40 percent of Africans live in poverty, subsisting on less than US$1 a day. As co-founder and CEO of the nonprofit social enterprise KickStart, Fisher develops and markets moneymaking tools such as low-cost, &#8230; <a href="http://engineering.curiouscatblog.net/2010/02/10/100000-lemelson-mit-award-for-sustainability/">Continue reading <span class="meta-nav">&#8594;</span></a>]]></description>
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<p>According to the United Nations, more than 40 percent of Africans live in poverty, subsisting on less than US$1 a day. As co-founder and CEO of the nonprofit social enterprise <a href="http://www.kickstart.org/">KickStart</a>, Fisher develops and markets moneymaking tools such as low-cost, human-powered irrigation pumps that improve the lives of small-scale rural farmers – the majority of the poor in sub-Saharan Africa.</p>
<p>&#8220;These poor rural farmers have one asset: a small plot of land; and one basic skill: farming. The best business they can pursue is irrigated farming,&#8221; Fisher explained. &#8220;Once they employ irrigation, the farmers can grow and sell high-value crops, like fruits and vegetables. They can grow year-round and reap four or five harvests, instead of waiting for the rain to grow a staple crop once or twice a year.&#8221; </p>
<p>Related: <a href="http://engineering.curiouscatblog.net/2008/12/11/high-school-inventor-teams-mit/">High School Inventor Teams @ MIT</a> &#8211; <a href="http://engineering.curiouscatblog.net/2008/02/10/water-pump-merry-go-round/">Water Pump Merry-go-Round</a> &#8211; <a href="http://engineering.curiouscatblog.net/2008/12/25/appropriate-technology-self-adjusting-glasses/">Appropriate Technology: Self Adjusting Glasses</a> &#8211; <a href="http://engineering.curiouscatblog.net/2008/07/18/fixing-the-world-on-2-a-day/">Fixing the World on $2 a Day</a><br />
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The <a href="http://www.kickstart.org/products/super-moneymaker/">Super MoneyMaker Pump</a>, can pull water from a source (such as a pond, lake, stream, or well) as deep as 30 feet below the pump. It can then pressurize the water and spray it continuously to a height over 40 feet above the pump. It can also push water through a hosepipe for as far as 1,000 feet on flat ground, and it has the ability to irrigate as much as two acres of land. It retails for about US$100, and its users are earning an average of US$1,000 profit per year.</p>
<p>More recently, Fisher and his KickStart team invented the MoneyMaker Hip Pump, which is more affordable than the Super MoneyMaker Pump to lower barriers of entry to commercial irrigation. Unlike a treadle pump, its unique pivoted design allows the operator to pump water using his or her arms, legs, and body weight in an easy-to-use rocking motion. More than 4,300 farmers in Kenya, Tanzania, and Mali are already using this pump. The Hip Pump retails for about US$35; it can be used to irrigate over an acre of land, and its users are earning an average annual profit of US$650.</p>
<p>&#8220;The MoneyMaker pumps Martin designed are inspirational on many levels,&#8221; said award nominator David M. Kelley, IDEO chairman and founder of the Hasso Plattner Institute of Design at Stanford University. &#8220;The inventions are remarkable in the huge impacts they have had on poverty and the lives of hundreds of thousands of poor farmers in Africa. They are an exceedingly simple solution to a very complex problem.&#8221;</p>
<p>At present, nearly 62,000 small-scale farmers and entrepreneurs in Kenya, Tanzania and Mali are running profitable businesses by using MoneyMaker pumps. On average, farmers double or triple their annual net household incomes. Current pump users generate total new revenues equivalent to 0.6 percent of Kenya&#8217;s GDP, and 0.25 percent of Tanzania&#8217;s GDP. </p>
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