Posted on April 29, 2009  Comments (0)

WHO Director-General, Dr Margaret Chan, announced today that she has “decided to raise the current level of influenza pandemic alert from phase 4 to phase 5.” And she further comments:

Let me remind you. New diseases are, by definition, poorly understood. Influenza viruses are notorious for their rapid mutation and unpredictable behaviour. WHO and health authorities in affected countries will not have all the answers immediately, but we will get them.

WHO will be tracking the pandemic at the epidemiological, clinical, and virological levels. All countries should immediately activate their pandemic preparedness plans. Countries should remain on high alert for unusual outbreaks of influenza-like illness and severe pneumonia.

At this stage, effective and essential measures include heightened surveillance, early detection and treatment of cases, and infection control in all health facilities.

I have reached out to companies manufacturing antiviral drugs to assess capacity and all options for ramping up production. I have also reached out to influenza vaccine manufacturers that can contribute to the production of a pandemic vaccine.

The biggest question, right now, is this: how severe will the pandemic be, especially now at the start?

It is possible that the full clinical spectrum of this disease goes from mild illness to severe disease. We need to continue to monitor the evolution of the situation to get the specific information and data we need to answer this question.

From past experience, we also know that influenza may cause mild disease in affluent countries, but more severe disease, with higher mortality, in developing countries.

No matter what the situation is, the international community should treat this as a window of opportunity to ramp up preparedness and response.

Above all, this is an opportunity for global solidarity as we look for responses and solutions that benefit all countries, all of humanity. After all, it really is all of humanity that is under threat during a pandemic.

As I have said, we do not have all the answers right now, but we will get them.
—- end of her remarks —-
The latest WHO Epidemic and Pandemic Alert and Response release puts the total number of confirmed cases at 148, in 9 countries, with 8 deaths. Mexico has many more suspected cases but just 26 confirmed cases. The CDC Swine Influenza site, puts the total number of confirmed cases in the USA at 91, in 10 states, with 1 death.

Related: Swine Flu: a Quick Overview – Swine Flu One Step Closer to Pandemic – posts on influenza – Why the Flu Likes Winter – Reducing the Impact of a Flu Pandemic

Posted on April 28, 2009  Comments (1)

Today, during remarks at the National Academy of Sciences, President Barack Obama announced the President’s Council of Advisors on Science and Technology (PCAST).

PCAST is an advisory group of the nation’s leading scientists and engineers who will advise the President and Vice President and formulate policy in the many areas where understanding of science, technology, and innovation is key to strengthening our economy and forming policy that works for the American people.

President Barack Obama said, “This council represents leaders from many scientific disciplines who will bring a diversity of experience and views. I will charge PCAST with advising me about national strategies to nurture and sustain a culture of scientific innovation.”

PCAST will be co-chaired by John Holdren, Assistant to the President for Science and Technology and Director of the White House Office of Science and Technology Policy; Eric Lander, Director of the Broad Institute of MIT and Harvard and one of the principal leaders of the Human Genome Project; and Harold Varmus, President and CEO of Memorial Sloan-Kettering Cancer Center, former head of the National Institutes of Health and a Nobel laureate.

Members of the council include: Shirley Ann Jackson, Craig Mundie, Eric Schmidt and Ahmed Zewail.

Related: Science and Engineering in Politics – Scientists and Engineers in Congress – John Conyers Against Open Science – China’s Technology Savvy Leadership

Posted on April 27, 2009  Comments (0)

Related: Home Experiments: Quantum Erasing – posts on physics – MIT Physics Lecture: Electromagnetism (Faraday’s Law & Lenz Law) – 10 Most Beautiful Physics Experiments

Posted on April 27, 2009  Comments (0)

Engineering suddenly hot at universities

Increased engineering education is good news for future economic growth. Hopefully this trend can continue.

Related: Webcast: Engineering Education in the 21st Century – Many S&P 500 CEOs are Engineering Graduates – Women Choosing Other Fields Over Engineering and Math – Engineering Education Study Debate – Science and Engineering in Global Economics

Posted on April 26, 2009  Comments (8)

World Health Organization on Swine influenza

Swine flu: a quick overview–and new New York and Kansas cases by Tara Smith

This is very early in the scientific inquiry process looking into what exactly is going on. It is too early to tell how serious a threat this is. The reaction of WHO, CDC though shows they are taking the threat seriously. By far the biggest danger in such situations, is reacting too slowly to serious and contagious threats. If you wait to react until proof exists that the situation is very serious the situation can be almost impossible to control. So you need to react quickly to shut down the spread of the threat, hopefully before it has spread too far.

Related: CDC site on Human Swine Influenza Investigation – Interview with Dr. Tara Smith – Reducing the Impact of a Flu Pandemic – H5N1 Influenza Evolution and Spread
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Posted on April 26, 2009  Comments (0)

Evolutionary Robotics, chapter of Handbook of Robotics, is interesting and includes a good explanation of the difference between evolution and learning:

Related: What are Genetic Algorithms? – Evolutionary Design – Laboratory of Intelligent Systems – Robot with Biological Brain – posts on robotics

Posted on April 25, 2009  Comments (2)

Graphic of Blood Falls showing microbial community environment in the Antarctic by Zina Deretsky at NSF)

A reservoir of briny liquid buried deep beneath an Antarctic glacier supports hardy microbes that have lived in isolation for millions of years, researchers report this week. The discovery of life in a place where cold, darkness, and lack of oxygen would previously have led scientists to believe nothing could survive comes from a team led by researchers at Harvard University and Dartmouth College.

Despite their profound isolation, the microbes are remarkably similar to species found in modern marine environments, suggesting that the organisms now under the glacier are the remnants of a larger population that once occupied an open fjord or sea.

“It’s a bit like finding a forest that nobody has seen for 1.5 million years,” says Ann Pearson, Thomas D. Cabot Associate Professor of Earth and Planetary Sciences in Harvard’s Faculty of Arts and Sciences. “Intriguingly, the species living there are similar to contemporary organisms, and yet quite different — a result, no doubt, of having lived in such an inhospitable environment for so long.”

“This briny pond is a unique sort of time capsule from a period in Earth’s history,” says lead author Jill Mikucki, now a research associate in the Department of Earth Sciences at Dartmouth and visiting fellow at Dartmouth’s Dickey Center for International Understanding and its Institute of Arctic Studies. “I don’t know of any other environment quite like this on Earth.”

Chemical analysis of effluent from the inaccessible subglacial pool suggests that its inhabitants have eked out a living by breathing iron leached from bedrock with the help of a sulfur catalyst. Lacking any light to support photosynthesis, the microbes have presumably survived by feeding on the organic matter trapped with them when the massive Taylor Glacier sealed off their habitat an estimated 1.5 to 2 million years ago.
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Posted on April 24, 2009  Comments (3)

I, John Hunter, work for the American Society for Engineering Education as an Information Technology Program Manager. My work on this blog is not associated with ASEE and the opinions I express are mine and not those of ASEE. That said, we are looking for a Ruby on Rails developer at ASEE, in Washington DC.

class Employee < ActiveRecord::Base

acts_as_programmer

has_many :talents
has_and_belongs_to_many :computer_languages

after_create :schedule_interview

validates_inclusion_of :salary,
:in => 60000..80000,
:message => “should be between $60k and $80k a year”
validates_inclusion_of :years_of_experience,
:in => 2..7,
:message => “should be between 2 and 7 years”

validates_presence_of :resume
validates_interest_in :ruby_on_rails
validates_interest_in :agile software development

REQUIRED_LANGUAGES = ["Ruby","Perl","Python","JavaScript","Lisp"]

def validate
errors.add_to_base(“You must know one of the languages”) unless
(computer_languages.map{|x| x.name} & REQUIRED_LANGUAGES).size > 0
end

def schedule_interview
self.interviewer = Interviewer.create(
:name => “Keith Mounts”,
:url => “www.asee.org/about/contactASEE.cfm“,
)
save
end

def hire
vacation_days = 15
telecommuting_days_per_week = 0..2
office_location = “dupont circle metro stop, washington, dc”
environment = “friendly”
company = “american society for engineering education”
save
end

end

class ApplyController < ApplicationController

def index
@employee = Employee.new
end

def apply
@employee = Employee.new
if @employee.update_attributes(params[:employee])
flash[:notice] = "Thanks for applying! I'll get back to you very soon!"
redirect_to :action => “thanks”
else
render :action => “index”
end
end

end

Modified from job announcement created by Sean Stickle when he was at ASEE. Related: Ruby on Rails Job Opportunity

Posted on April 24, 2009  Comments (0)

Artificial Intelligence Cracks 4,000-Year-Old Mystery by Brandon Keim

Related: The Rush to Save Timbuktu’s Crumbling Manuscripts – The Mystery of the Voynich Manuscript – Aztec Math

Posted on April 22, 2009  Comments (5)

In a, chlorotoxin molecules, colored blue and green, attach themselves to a central nanoparticle. In b, each nanoprobe offers many chlorotoxin molecules that can simultaneously latch on to many MMP-2s, depicted here in yellow, which are thought to help tumor cells travel through the body. In c, over time nanoprobes draw more and more of the MMP-2 surface proteins into the cell, slowing the tumor’s spread. Image from the University of Washington.

University of Washington researchers found they could cut the spread of cancerous cells by 98 percent, compared to 45 percent for the scorpion venom alone, by combining nanoparticles with a scorpion venom compound already being investigated for treating brain cancer.

For more than a decade scientists have looked at using chlorotoxin, a small peptide isolated from scorpion venom, to target and treat cancer cells. Chlorotoxin binds to a surface protein overexpressed by many types of tumors, including brain cancer. Previous research by Miqin Zhang‘s group combined chlorotoxin with nanometer-scale particles of iron oxide, which fluoresce at that size, for both magnetic resonance and optical imaging.

Chlorotoxin also disrupts the spread of invasive tumors — specifically, it slows cell invasion, the ability of the cancerous cell to penetrate the protective matrix surrounding the cell and travel to a different area of the body to start a new cancer. The MMP-2 on the cell’s surface, which is the binding site for chlorotoxin, is hyperactive in highly invasive tumors such as brain cancer. Researchers believe MMP-2 helps the cancerous cell break through the protective matrix to invade new regions of the body. But when chlorotoxin binds to MMP-2, both get drawn into the cancerous cell.

Research showed that the cells containing nanoparticles plus chlorotoxin were unable to elongate, whereas cells containing only nanoparticles or only chlorotoxin could stretch out. This suggests that the nanoparticle-plus-chlorotoxin disabled the machinery on the cell’s surface that allows cells to change shape, yet another step required for a tumor cell to slip through the body.

So far most cancer research has combined nanoparticles either with chemotherapy that kills cancer cells, or therapy seeking to disrupt the genetic activity of a cancerous cell. This is the first time that nanoparticles have been combined with a therapy that physically stops cancer’s spread.

Full press release

Related: Using Bacteria to Carry Nanoparticles Into Cells – Global Cancer Deaths to Double by 2030 – Nanoengineers Use Tiny Diamonds for Drug Delivery

Posted on April 21, 2009  Comments (3)

The barriers between countries, related to jobs, are decreasing. Jobs are more international today than 20 years ago and that trend will continue. People are going to move to different countries to do jobs (especially in science, engineering and advanced technology). The USA has a good market on those jobs (for many reasons). But there is nothing that requires those jobs to be in the USA.

The biggest impact of the USA turning away great scientists and engineers will be that they go to work outside the USA and increase the speed at which the USA loses its place as the leading location for science, engineering and technology work. This is no longer the 1960′s. Back then those turned away by the USA had trouble finding work elsewhere that could compete with the work done in the USA. If the USA wants to isolate ourselves (with 5% of the population) from a fairly open global science and engineering job market, other countries will step in (they already are trying, realizing what a huge economic benefit doing so provides).

Those other countries will be able to put together great centers of science and engineering innovation. Those areas will create great companies that create great jobs. I can understand wanting this to be 1960, but wanting it doesn’t make it happen.

You could go even further and shut off science and engineering students access to USA universities (which are the best in the world). That would put a crimp in plans for a very short while. Soon many professors would move to foreign schools. The foreign schools would need those professors, and offer a great deal of pay. And those professors would need jobs as their schools laid off professors as students disappeared. Granted the best schools and best professors could stay in the USA, but plenty of very good ones would leave.

I just don’t think the idea of closing off the companies in the USA from using foreign workers will work. We are lucky now that, for several reasons, it is still easiest to move people from Germany, India, Korea, Mexico and Brazil all to the USA to work on advanced technology projects. The advantage today however, is much much smaller than it was 30 years ago. Today just moving all those people to some other location, say Singapore, England, Canada or China will work pretty well (and 5 years from now will work much better in whatever locations start to emerge as the leading alternative sites). Making the alternative of setting up centers of excellence outside the USA more appealing is not a good strategy for those in the USA wanting science, engineering and computer programming jobs. We should instead do what we can to encourage more companies in the USA that are centralizing technology excellence in the USA.

Comment on Reddit discussion.

Related: Science and Engineering in Global Economics – Global technology job economy – Countries Should Encourage Immigration of Technology Workers – The Software Developer Labor Market – What Graduates Should Know About an IT Career – Relative Engineering Economic Positions – China’s Technology Savvy Leadership – Education, Entrepreneurship and Immigration – The Future is Engineering – Global Technology Leadership