The work takes advantage of a gene called halorhodopsin found in a bacterium that grows in extremely salty water, such as the Great Salt Lake in Utah. In the bacterium, Natronomas pharaonis, the gene codes for a protein that serves as a light-activated chloride pump, which helps the bacterium make energy.

When neurons are engineered to express the halorhodopsin gene, the researchers can inhibit their activity by shining yellow light on them. Light activates the chloride pumps, which drive chloride ions into the neurons, lowering their voltage and silencing their firing.
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The group also plans to use the new method to study neural circuits. Last year, Boyden devised a technique to stimulate neurons by shining blue light on them, so with blue and yellow light the researchers can now exert exquisite control over the stimulation and inhibition of individual neurons. Learning more about the neural circuits involved in epilepsy could help scientists develop devices that can predict when a seizure is about to occur, allowing treatment (either shock or light) to be administered only when necessary, Boyden said.

Established in 2004, the institute was originally designed to help advance engineering after USC alumnus and venture capitalist Mark Stevens and his wife, Mary, donated $22 million to the campus unit.
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In the spirit of innovation, Provost C.L. Max Nikias also announced he wants to develop in the next year a minor in innovation for all doctoral students, regardless of their discipline. “I want innovation to be the signature for the USC PhD diploma,” Nikias said. To oversee the institute’s new effort, USC officials last year recruited Krisztina Holly, a former director of an innovation center at the Massachusetts Institute of Technology.
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If one of USC’s 33,000 students has an idea, he or she should contact the institute that is housed in the Andrew and Erna Viterbi School of Engineering and speak with an innovator developer to determine if the idea has merit.

Beekeepers throughout the United States have been losing between 50 and 90 percent of their honeybees over the past six months, perplexing scientists, driving honey prices higher and threatening fruit and vegetable production.

At a House Agricultural Subcommittee hearing in Washington, D.C., today, members of various organizations came together to share their concerns about what they have been calling the “Colony Collapse Disorder,” or CCD. Beginning in October 2006, beekeepers from 24 states reported that hundreds of thousands of their bees were dying and their colonies were being devastated.

Countries were judged on technological advancements in general business, the infrastructure available and the extent to which government policy creates a framework necessary for economic development and increased competitiveness. The Networked Readiness Index, the sixth of its kind published by the World Economic Forum with Insead, the Paris-based business school, scrutinised progress in 122 economies worldwide.

Despite losing its top position, the US still maintained a strong focus on innovation, driven by one of the world’s best tertiary education systems and its high degree of co-operation with industry, the report said. The country’s efficient market environment, conducive to the availability of venture capital, and the sophistication of financial markets, was also given recognition.

“We thought we were doing it wrong. We thought we must have made a mistake,” Anna told New Zealand’s Weekend Herald. The girls were both 14 and students at Pakuranga College in Auckland when they did the experiment in 2004. Given Ribena’s advertising claims that “the blackcurrants in Ribena have four times the vitamin C of oranges”, they were astonished and wrote to the manufacturers, GlaxoSmithKline (GSK). When they got no response, they phoned the company, but were given short shrift. “They didn’t even really answer our questions. They just said it’s the blackcurrants that have it, then they hung up,” Jenny said.

But then the girls’ claims were picked up by a TV consumer affairs programme, Fair Go, which suggested they take their findings to the commerce commission, a government watchdog. GSK said the girls had tested the wrong product, and it was concentrated syrup which had four times the vitamin C of oranges. But when the commerce commission investigated, it found that although blackcurrants have more vitamin C than oranges, the same was not true of Ribena. It also said ready-to-drink Ribena contained no detectable level of vitamin C.

GSK is in court in Auckland today facing 15 charges relating to misleading advertising, risking fines of up to NZ$3m (£1.1m). In Australia, GSK has admitted that its claims about Ribena may have misled consumers.

Viruses invade a cell by latching onto certain proteins on its surface. Once attached, they can slip inside the cell and manipulate it into making new copies of themselves. But viruses cannot infect red blood cells. Unlike most other cells in the body, as red blood cells develop in bone marrow they lose their DNA. If a virus ends up inside a red blood cell, there are no genes it can hijack to replicate itself.

“It occurred to us that if a virus bound to a red blood cell, that was a dead end,” said Dr. Robert W. Finberg, a professor at the University of Massachusetts Medical School.
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To test the model, the scientists mixed normal bacteria with different levels of mutant traps and then infected them with viruses. After letting the viruses replicate, the scientists took a small sample to start a new colony. They discovered there was indeed a trap threshold above which the virus population could not survive. Above that threshold, the viruses disappeared by the time the scientists started the third round of colonies.

Science in School aims to promote inspiring science teaching by encouraging communication between teachers, scientists, science teachers and everyone else involved in European science education. Science in School addresses science teaching both across Europe and across disciplines: highlighting the best in teaching and cutting-edge research. It covers not only biology, physics and chemistry, but also maths, earth sciences, engineering and medicine, focusing on interdisciplinary work.

The contents include teaching materials; cutting-edge science; education projects; interviews with young scientists and inspiring teachers; European education news; reviews of books and other resources; and European events for teachers.

Two engineering students at the University of Iceland have designed an innovative hand dryer, which is powered by hot water and uses only ten percent of the energy that conventional hand dryers need.
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The students’ instructor, Thorsteinn Ingi Sigfússon, a professor in physics, got the idea for the hand dryer. The students received a grant from The Icelandic Student Innovation Fund to develop his idea.
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The water goes through a process of metabolism when it comes in touch with a special heating element inside the hand dryer and changes into air, which is blown out of the hand dryer with a fan, as described by one of the designers, Hildigunnur Jónsdóttir.

This summer my project will be to come up with a set of resources and instructions that will allow regular non-engineer people (and kids) to put together a drone for less than $1,000 that has most if not all of the functionality of this $10,000 beauty. The DraganFlyer autonomous helicopter platform shown above starts at just $2,400, and these guys seem to have made good progress on the essentials of a $500 helicopter UAV

The feasibility for in vivo navigation of untethered devices or robots is demonstrated with the control and tracking of a 1.5 mm diameter ferromagnetic bead in the carotid artery of a living swine using a clinical magnetic resonance imaging (MRI) platform. Navigation is achieved by inducing displacement forces from the three orthogonal slice selection and signal encoding gradient coils of a standard MRI system. The proposed method performs automatic tracking, propulsion, and computer control sequences at a sufficient rate to allow navigation along preplanned paths in the blood circulatory system.

Africa’s large AIDS population is at special risk from the particularly virulent strain, known as XDR-TB (extremely drug resistant), which had been documented in 35 countries worldwide, 16 of them in this year. “This is the most urgent thing I have seen in my 15 years of working on tuberculosis,” said Mario Raviglione, director of the STOP TB program at the World Health Organization. He introduced WHO’s TB report, which coincides with the 125th anniversary of the discovery of the microbe that causes TB.
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Some 2 billion people worldwide live with TB, an airborne illness that is normally treatable through inexpensive medication. But if the disease is not diagnosed and treated, it can mutate into drug-resistant strains. In 2005, nearly 9 million people became infected with tuberculosis and 1.6 million died of it, about the same as the year before, which showed that containment efforts were working, Raviglione said. The epidemic is centered primarily in Asia and in Africa, which accounted for 84 percent of the total.

“The good news is that the global incidence may have peaked,” particularly in China, India, and Indonesia, he said. “The bad news is that although the incidence has declined [there] is resistance to most powerful first-line drugs and a form of TB that is resistant to second-line drugs.”

B12, the most chemically complex of all vitamins, is essential for human health. Four Nobel Prizes have been awarded for research related to B12, but one fragment of the molecule remained an enigma–until now. The researchers report that a single enzyme synthesizes the fragment, and they outline a novel reaction mechanism that requires cannibalization of another vitamin.
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Vitamin B12 is produced by soil microbes that live in symbiotic relationships with plant roots.
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BluB catalyzes the formation of the B12 fragment known as DMB, which joins with another fragment, produced by a separate pathway, to form the vitamin. One of several possible reasons why it took so long to identify BluB is that some bacteria lacking the enzyme can form DMB through an alternate pathway, Walker said.

One of the most unusual aspects of BluB-catalyzed synthesis is its cannibalization of a cofactor derived from another vitamin, B2. During the reaction, the B2 cofactor is split into more than two fragments, one of which becomes DMB. Normally, the B2-derived cofactor would assist in a reaction by temporarily holding electrons and then giving them away. Such cofactors are not consumed in the reaction.

But it’s hard to preach that wisdom to someone with a drippy, hurting sinus who wants immediate relief, Leopold acknowledged. Because more effective drugs are lacking, “patients are desperate, physicians are desperate, and it is not a happy situation,” he said.

And so the physician often makes the practical choice of giving what the patient wants, with a chance of relief, over the more abstract issue of antibiotic resistance, he said.

As long ago as 1994, the Swiss voted in a nationwide referendum to put all freight crossing their country onto the railways. Naturally, such an ambitious plan was not going to happen overnight, but now the project dubbed the engineering feat of the 21st Century is slowly taking shape.

Deep beneath the Alps, the Swiss are building a high-speed rail link between Zurich and Milan. It will include, at 57 kilometres (35 miles), the world’s longest tunnel. A key feature of the project, which is new to alpine transport, is the fact that the entire railway line will stay at the same altitude of 500 metres (1,650ft) above sea level.
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In fact the price tag for the entire rail link has soared from about $8bn (£4bn) to almost $15bn and final completion is unlikely to be before 2018.

If you own a birdbath, chances are you’re hosting one of evolutionary biology’s most puzzling enigmas: bdelloid rotifers. These microscopic invertebrates—widely distributed in mosses, creeks, ponds, and other freshwater repositories—abandoned sex perhaps 100 million years ago, yet have apparently diverged into nearly 400 species. Bdelloids (the “b” is silent) reproduce through parthenogenesis, which generates offspring with essentially the same genome as their mother from unfertilized eggs.

Bdelloid rotifers are egg laying microscopic invertebrates — widely distributed in mosses, streams and ponds — which have managed to diverge into nearly 400 species without a scintilla of sex… Now a new study, published today in the journal PLoS biology, has confirmed the worst fears of scientists: the rotifers do indeed present a major challenge to the assumption that sex is necessary for organisms to diversify into species.
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Rather than mixing up DNA, creatures like the bdelloid rotifers can evolve solely through the build-up of mutations that occur in the ‘cloning’ process when a new rotifer is born. The new study proves that these differences are not random and can help rotifers adapt to a different environment, such as the legs or chest of a water louse. Bdelloids can be found happily swimming around in a puddle in your garden, hot springs or in freezing ponds in the Antarctic.